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Feedback regulation of TGF-β signaling

Yan, Xiaohua, Xiong, Xiangyang, Chen, Ye-Guang·2018·Acta Biochimica et Biophysica Sinica
DOI 10.1093/abbs/gmx129
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Crossref · 10.1093/abbs/gmx129

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  • When ligand levels diminish, attenuators also diminish and receptors increase; signaling re-boot induces negative regulators, as observed for follistatin and follistatin-like, secondarily diminishing the intensity of age-elevated pathways.

    “When the levels of ligand(s) diminish, attenuators also diminish, and receptor(s) increase [62, 63]; signaling re-boot induces negative regulators, as we observed for follistatin and follistatin-like, secondarily diminishing the intensity of age-elevated pathways [64–66].”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [62]

    The section “Feedback on the Receptors” (page unavailable) says TGF-β-family cytokines induce inhibitory Smad6 and Smad7, establishing negative feedback loops. That supports the general claim that signaling can induce regulators that limit signaling. The cited paper does not establish the claimed effect on age-elevated pathways; the follistatin observation is presented as the citing authors’ own. (LLM, conf=0.84)

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Metadata

Authors
Yan, X., Xiong, X., & Chen, Y.-G.
Venue
Acta Biochimica et Biophysica Sinica
Publisher
China Science Publishing & Media Ltd.
Published
2018-01-01
Volume
50
Issue
1
Pages
37-50
ISSN
1672-9145
DOI
10.1093/abbs/gmx129
Cited by
128
References
9
Language
en

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