The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy
Abstract
UNC‐51 like kinase (ULK1) translocates to dysfunctional mitochondria and is involved in mitophagy, but the mechanisms responsible for ULK1 activation and translocation remain unclear. Here, we found that hypoxia induces phosphorylation of ULK1 at Serine‐555 by Adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK). Unlike wild‐type ULK1, an ULK1 (S555A) mutant cannot translocate to mitochondria in response to hypoxia. Inhibition or knockdown of AMPK prevents ULK1 translocation and inhibits mitophagy. Finally, the phospho‐mimic ULK1 (S555D) mutant, but not ULK1 (S555A), rescues mitophagy in AMPK‐knockdown cells. Thus, we conclude that AMPK‐dependent phosphorylation of ULK1 is critical for translocation of ULK1 to mitochondria and for mitophagy in response to hypoxic stress.
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Cites
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
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Nix is a selective autophagy receptor for mitochondrial clearance
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Ma, K., Chen, G., Li, W., Kepp, O., Zhu, Y., & Chen, Q. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00467 · Cited by 594
Self-citationLaker, R. C., Drake, J. C., Wilson, R. J., Lira, V. A., Lewellen, B. M., Ryall, K. A., Fisher, C. C., Zhang, M., Saucerman, J. J., Goodyear, L. J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00520-9 · Cited by 529
Self-citationSelective autophagy of intracellular organelles: Recent research advances
Li, W., He, P., Huang, Y., Li, Y.-F., Lu, J., Li, M., Kurihara, H., Luo, Z., Meng, T., Onishi, M., et al. (2021) · Theranostics · doi:10.7150/thno.49860 · Cited by 507
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Metadata
- Authors
- Tian, W., Li, W., Chen, Y., Yan, Z., Huang, X., Zhuang, H., Zhong, W., Chen, Y., Wu, W., Lin, C., Chen, H., Hou, X., Zhang, L., Sui, S., Zhao, B., Hu, Z., Li, L., & Feng, D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2015-05-14
- Volume
- 589
- Issue
- 15
- Pages
- 1847-1854
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W258002656
- Cited by
- 199
- References
- 13
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tian, W., Li, W., Chen, Y., Yan, Z., Huang, X., Zhuang, H., Zhong, W., Chen, Y., Wu, W., Lin, C., Chen, H., Hou, X., Zhang, L., Sui, S., Zhao, B., Hu, Z., Li, L., & Feng, D. (2015). Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy. FEBS Letters. https://doi.org/10.1016/j.febslet.2015.05.020
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