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Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles
Abstract
Extracellular vesicles (EVs) contain microRNAs (miRNAs). However, the exact molecular mechanisms of the recruitment of miRNAs in EVs are not well characterized. Based on proteomic analysis, we identified that silencing of Annexin A2 (ANXA2) significantly decreased the amount of miRNAs in EVs. In addition, microarray analysis revealed that ANXA2 regulated the loading of miRNAs into EVs in a sequence independent manner. Lastly, immunoprecipitation analysis confirmed that ANXA2 could bind miRNAs in EVs in the presence of Ca 2+ . These observations demonstrate that ANXA2 plays an important role in the packaging process of miRNAs into EVs.
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“Silencing ANXA2 significantly decreased the number of miRNAs loaded into sEVs but did not significantly change the miRNA profiles compared to controls, indicating ANXA2 is involved in a passive sorting.”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [72]
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“Annexin A2 (ANXA2) can alter the miRNAs loaded into sEVs by binding to miRNAs in a sequence-free manner [72].”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [72]
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Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107821 · Cited by 1,934
Self-citationEmmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5699-09.2010 · Cited by 1,115 · cited 1×
“also reported that an increase in the intracellular Ca concentration can stimulate EV secretion [24].”
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Cited by
Sorted by citations
Reassessment of exosome composition
Jeppesen, D. K., Fenix, A. M., Franklin, J. L., Higginbotham, J. N., Zhang, Q., Zimmerman, L. J., Liebler, D. C., Ping, J., Liu, Q., Evans, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.029 · Cited by 2,975
RNA delivery by extracellular vesicles in mammalian cells and its applications
O’Brien, K., Breyne, K., Ughetto, S., Laurent, L. C., & Breakefield, X. O. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0251-y · Cited by 1,811
A platform for actively loading cargo RNA to elucidate limiting steps in EV‐mediated delivery
Hung, M. E., & Leonard, J. N. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31027 · Cited by 251
Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis
Jackson, C. E., Scruggs, B. S., Schaffer, J. E., & Hanson, P. I. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2017.05.032 · Cited by 118
Differential RNA packaging into small extracellular vesicles by neurons and astrocytes
Luo, X., Jean-Toussaint, R., Sacan, A., & Ajit, S. K. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00757-4 · Cited by 32
Metadata
- Authors
- Hagiwara, K., Katsuda, T., Gailhouste, L., Kosaka, N., & Ochiya, T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2015-11-26
- Volume
- 589
- Issue
- 24PartB
- Pages
- 4071-4078
- ISSN
- 0014-5793
- 1873-3468
- Cited by
- 95
- References
- 2
- Language
- en
- Funders
- Japanese Ministry of Education, Culture, Sports, Science, and Technology
- Japanese National Institute of Biomedical Innovation
- Japan Society for the Promotion of Science
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