MicroRNA regulation by RNA-binding proteins and its implications for cancer
Abstract
Non-protein-coding transcripts have been conserved throughout evolution, indicating that crucial functions exist for these RNAs. For example, microRNAs (miRNAs) have been found to modulate most cellular processes. The protein classes of RNA-binding proteins include essential regulators of miRNA biogenesis, turnover and activity. RNA-RNA and protein-RNA interactions are essential for post-transcriptional regulation in normal development and may be deregulated in disease. In reviewing emerging concepts of the interplay between miRNAs and RNA-binding proteins, we highlight the implications of these complex layers of regulation in cancer initiation and progression.
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Multiple RNA binding proteins (RBPs) are reported to modulate miRNA function.
“multiple RNA binding proteins (RBPs) are reported to modulate miRNA function29”
From Gain-of-function mutation of microRNA-140 in human skeletal dysplasia (2019) · cites this paper as [29]
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- Authors
- van Kouwenhove, M., Kedde, M., & Agami, R.
- Affiliations
- The Netherlands Cancer Institute (NL)
- Corresponding author
- Agami, Reuven
- Venue
- Nature Reviews Cancer
- Published
- 2011-08-05
- Volume
- 11
- Issue
- 9
- Pages
- 644-656
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1986630370
- Cited by
- 617
- References
- 12
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 20 · 2023: 14 · 2022: 22 · 2021: 30 · 2020: 39 · 2019: 38 · 2018: 33 · 2017: 50 · 2016: 61 · 2015: 72 · 2014: 66 · 2013: 69 · 2012: 73
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, RNA-binding proteins, microRNA biogenesis, post-transcriptional regulation, RNA-protein interactions, RNA-RNA interactions, non-coding RNA, tumor initiation, tumor progression
- MeSH terms
- Humans, Models, Genetic, Neoplasms, RNA-Binding Proteins, RNA Interference, RNA-Induced Silencing Complex, MicroRNAs
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