The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis
Abstract
In the past several years, the importance of microRNA (miRNA) in cancer cells has been recognized. Proper control of miRNA expression is essential for maintaining a steady state of the cellular machinery. Recently, it was discovered that extracellular miRNAs circulate in the blood of both healthy and diseased patients, although ribonuclease is present in both plasma and serum. Most of the circulating miRNAs are included in lipid or lipoprotein complexes, such as apoptotic bodies, microvesicles, or exosomes, and are, therefore, highly stable. The existence of circulating miRNAs in the blood of cancer patients has raised the possibility that miRNAs may serve as a novel diagnostic marker. However, the secretory mechanism and biological function, as well as the meaning of the existence of extracellular miRNAs, remain largely unclear. In this review, we summarize the usefulness of circulating miRNA for cancer diagnosis, prognosis, and therapeutics. Furthermore, we propose a mechanism for the secretion and incorporation of miRNA into the cells. ( Cancer Sci 2010)
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miRNAs can be released from cancer cells into body fluids via secreting exosomes particles.
“Intriguingly, miRNAs can be released from cancer cells into body fluids via secreting exosomes particles [6,13].”
From Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets (2015) · cites this paper as [6]
MicroRNAs (miRNAs) have become emerging potential cancer biomarkers.
“MicroRNAs (miRNAs) have become the emerging potential cancer biomarkers in recent years [3,4,5,6].”
From Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets (2015) · cites this paper as [6]
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Blood Cell Origin of Circulating MicroRNAs: A Cautionary Note for Cancer Biomarker Studies
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“Exosomal miRNAs may constitute biomarkers of a specific disease, as their serum levels are altered in a variety of pathological conditions (Kosaka et al., 2010a; Etheridge et al., 2011; Mo et al., 2012).”
BackgroundBaggish, A. L., Hale, A., Weiner, R. B., Lewis, G. D., Systrom, D., Wang, F., Wang, T. J., & Chan, S. Y. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.213363 · Cited by 431
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Elevated concentration of microvesicles isolated from peripheral blood in breast cancer patients
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Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype
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“Thefindingofaberrant expression in severalblood-basedmiRNAshasalso raisedthepossibility that these miRNAs serve as novel diagnostic markers for a variety of disorders (Kosaka et al., 2010; Lai et al., 2011).”
Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets
Kuo, W.-T., Su, M.-W., Lee, Y., Chen, C.-H., Wu, C.-W., Fang, W.-L., Huang, K.-H., & Lin, W.-C. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4091798 · Cited by 30
Metadata
- Authors
- Kosaka, N., Iguchi, H., & Ochiya, T.
- Venue
- Cancer Science
- Publisher
- Wiley
- Published
- 2010-06-18
- Volume
- 101
- Issue
- 10
- Pages
- 2087-2092
- ISSN
- 1347-9032
- 1349-7006
- Cited by
- 1,147
- References
- 5
- Language
- en
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