The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Some like it cold: biocatalysis at low temperatures
Open accessAbstract
In the last few years, increased attention has been focused on a class of organisms called psychrophiles. These organisms, hosts of permanently cold habitats, often display metabolic fluxes more or less comparable to those exhibited by mesophilic organisms at moderate temperatures. Psychrophiles have evolved by producing, among other peculiarities, "cold-adapted" enzymes which have the properties to cope with the reduction of chemical reaction rates induced by low temperatures. Thermal compensation in these enzymes is reached, in most cases, through a high catalytic efficiency associated, however, with a low thermal stability. Thanks to recent advances provided by X-ray crystallography, structure modelling, protein engineering and biophysical studies, the adaptation strategies are beginning to be understood. The emerging picture suggests that psychrophilic enzymes are characterized by an improved flexibility of the structural components involved in the catalytic cycle, whereas other protein regions, if not implicated in catalysis, may be even more rigid than their mesophilic counterparts. Due to their attractive properties, i.e., a high specific activity and a low thermal stability, these enzymes constitute a tremendous potential for fundamental research and biotechnological applications.
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Metadata
- Authors
- Georlette, D., Blaise, V., Collins, T., D'Amico, S., Gratia, E., Hoyoux, A., Marx, J.-C., Sonan, G., Feller, G., & Gerday, C.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-02
- Volume
- 28
- Issue
- 1
- Pages
- 25-42
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2092661289
- Cited by
- 422
- References
- 92
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Georlette, D., Blaise, V., Collins, T., D'Amico, S., Gratia, E., Hoyoux, A., Marx, J.-C., Sonan, G., Feller, G., & Gerday, C. (2004). Some like it cold: biocatalysis at low temperatures. FEMS Microbiology Reviews. https://doi.org/10.1016/j.femsre.2003.07.003
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