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Cited by 422

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Some like it cold: biocatalysis at low temperatures

Open access
Georlette, D., Blaise, V., Collins, T., D'Amico, S., Gratia, E., Hoyoux, A., Marx, J.-C., Sonan, G., Feller, G., Gerday, C.·2004·FEMS Microbiology Reviews

Abstract

In the last few years, increased attention has been focused on a class of organisms called psychrophiles. These organisms, hosts of permanently cold habitats, often display metabolic fluxes more or less comparable to those exhibited by mesophilic organisms at moderate temperatures. Psychrophiles have evolved by producing, among other peculiarities, "cold-adapted" enzymes which have the properties to cope with the reduction of chemical reaction rates induced by low temperatures. Thermal compensation in these enzymes is reached, in most cases, through a high catalytic efficiency associated, however, with a low thermal stability. Thanks to recent advances provided by X-ray crystallography, structure modelling, protein engineering and biophysical studies, the adaptation strategies are beginning to be understood. The emerging picture suggests that psychrophilic enzymes are characterized by an improved flexibility of the structural components involved in the catalytic cycle, whereas other protein regions, if not implicated in catalysis, may be even more rigid than their mesophilic counterparts. Due to their attractive properties, i.e., a high specific activity and a low thermal stability, these enzymes constitute a tremendous potential for fundamental research and biotechnological applications.

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Crossref · 10.1016/j.femsre.2003.07.003

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Metadata

Authors
Georlette, D., Blaise, V., Collins, T., D'Amico, S., Gratia, E., Hoyoux, A., Marx, J.-C., Sonan, G., Feller, G., & Gerday, C.
Venue
FEMS Microbiology Reviews
Published
2004-02
Volume
28
Issue
1
Pages
25-42
ISSN
  • 0168-6445 (ISSN-L)
  • 1574-6976
OpenAlex
W2092661289
Cited by
422
References
92
FWCI
5.25
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Some like it cold: biocatalysis at low temperatures. https://app.cochat.ai/papers/10.1016/j.femsre.2003.07.003
The paper
Georlette, D., Blaise, V., Collins, T., D'Amico, S., Gratia, E., Hoyoux, A., Marx, J.-C., Sonan, G., Feller, G., & Gerday, C. (2004). Some like it cold: biocatalysis at low temperatures. FEMS Microbiology Reviews. https://doi.org/10.1016/j.femsre.2003.07.003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.