Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome
Open accessAbstract
In women with polycystic ovary syndrome, metformin administration, not laparoscopic ovarian drilling, reduces plasminogen activator inhibitor 1 (PAI-1) activity. The lack of a decrease in PAI-1 activity is related to a high risk for miscarriage.
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Two medium-quality RCTs with moderate risk of bias found insufficient evidence to recommend laparoscopic ovarian surgery compared with metformin for live birth rate per patient, ovulation or pregnancy rate per cycle, pregnancy rate per patient and miscarriage rate per pregnancy.
“Two medium-quality RCTs (level II) with moderate risk of bias found insufficient evidence to recommend laparoscopic ovarian surgery compared with metformin for live birth rate per patient, ovulation or pregnancy rate per cycle, pregnancy rate per patient and miscarriage rate per pregnancy. 257-259”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [259]
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- Authors
- Palomba, S., Orio, F., Falbo, A., Russo, T., Tolino, A., & Zullo, F.
- Affiliations
- Magna Graecia University (IT)
- University of Naples Federico II (IT)
- Federico II University Hospital (IT)
- Corresponding author
- Palomba, Stefano
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 84
- Issue
- 3
- Pages
- 761-765
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2006169998
- Cited by
- 56
- References
- 27
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 2
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- plasminogen activator inhibitor-1, miscarriage, metformin, laparoscopic ovarian drilling, polycystic ovary syndrome, thrombosis risk, ovulation induction
- MeSH terms
- Abortion, Spontaneous, Female, Humans, Metformin, Ovary, Laparoscopy, Polycystic Ovary Syndrome, Pregnancy, Retrospective Studies, Plasminogen Activator Inhibitor 1
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