Cited by 56Ovarian function and disordersReproductive Biology and FertilityReproductive Health and Technologies

Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome

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Palomba, Stefano, Orio, Francesco, Falbo, Angela, Russo, Tiziana, Tolino, Achille, Zullo, Fulvio·2005·Fertility and Sterility

Abstract

In women with polycystic ovary syndrome, metformin administration, not laparoscopic ovarian drilling, reduces plasminogen activator inhibitor 1 (PAI-1) activity. The lack of a decrease in PAI-1 activity is related to a high risk for miscarriage.

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Crossref · 10.1016/j.fertnstert.2005.04.021

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  • Two medium-quality RCTs with moderate risk of bias found insufficient evidence to recommend laparoscopic ovarian surgery compared with metformin for live birth rate per patient, ovulation or pregnancy rate per cycle, pregnancy rate per patient and miscarriage rate per pregnancy.

    “Two medium-quality RCTs (level II) with moderate risk of bias found insufficient evidence to recommend laparoscopic ovarian surgery compared with metformin for live birth rate per patient, ovulation or pregnancy rate per cycle, pregnancy rate per patient and miscarriage rate per pregnancy. 257-259”

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Authors
Palomba, S., Orio, F., Falbo, A., Russo, T., Tolino, A., & Zullo, F.
Affiliations
  • Magna Graecia University (IT)
  • University of Naples Federico II (IT)
  • Federico II University Hospital (IT)
Corresponding author
Palomba, Stefano
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2005-09
Volume
84
Issue
3
Pages
761-765
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2006169998
Cited by
56
References
27
Citations by year
2024: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 2
FWCI
5.98
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords
plasminogen activator inhibitor-1, miscarriage, metformin, laparoscopic ovarian drilling, polycystic ovary syndrome, thrombosis risk, ovulation induction
MeSH terms
Abortion, Spontaneous, Female, Humans, Metformin, Ovary, Laparoscopy, Polycystic Ovary Syndrome, Pregnancy, Retrospective Studies, Plasminogen Activator Inhibitor 1

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