Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome
Abstract
BACKGROUND: Metformin has been shown to improve fertility in anovulatory patients with polycystic ovary syndrome (PCOS), inducing not only a high ovulation and pregnancy rate but also reducing the incidence of miscarriages. The aim of the present study was to evaluate the uterine effects of metformin in patients with PCOS who ovulated under metformin. METHODS: Thirty-seven non-obese primary infertile anovulatory patients with PCOS and another 30 age- and body mass index-matched healthy women (control group) were studied. PCOS patients were treated with metformin (850 mg twice daily) for 6 months, whereas the control group did not receive any treatment. In these PCOS patients who ovulated whilst under metformin treatment (PCOS group) and in controls, uterine, sub-endometrial and endometrial blood flow, and endometrial thickness and pattern were evaluated using serial ultrasonographic assessments. RESULTS: Before treatment, uterine, sub-endometrial and endometrial blood flows were significantly lower in patients with PCOS than in the control group. All indexes of uterine vascularization were significantly improved in the PCOS group with metformin treatment and were not different from the controls. Nor was any difference in endometrial thickness and pattern detected between PCOS and control groups. After grouping the data of PCOS patients who ovulated under metformin for cycles with favourable/unfavourable reproductive outcome, no difference in any parameter was observed. CONCLUSIONS: Metformin improves all surrogate markers of endometrial receptivity in PCOS patients, without difference between patients who had favourable or unfavourable reproductive outcome.
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Treatment with metformin improves markers of endometrial receptivity in women with PCOS, including increased uterine blood flow.
“Treatment with metformin, a drug prescribed for diabetes as well as PCOS, improves markers of endometrial receptivity in women with PCOS, including increased uterine blood flow (Palomba et al., 2006).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Palomba et al., 2006
Cites
Ultrasound assessment of the polycystic ovary: international consensus definitions
Balen, A. H., Laven, J. S. E., Tan, S.-L., & Dewailly, D. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg044 · Cited by 1,015 · see citing works
Metformin in polycystic ovary syndrome: systematic review and meta-analysis
Lord, J. M., Flight, I. H. K., & Norman, R. J. (2003) · BMJ · doi:10.1136/bmj.327.7421.951 · Cited by 786 · see citing works
Nestler, J. E., & Jakubowicz, D. J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608293350902 · Cited by 743 · see citing works
International recommendations and guidelines for the safe use of diagnostic ultrasound in medicine
Barnett, S. B., ter Haar, G., Ziskin, M. C., Rott, H., Duck, F. A., & Maeda, К. (2000) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(00)00204-0 · Cited by 401 · see citing works
Influence of Sex Hormones on Plasma Endothelin Levels
Polderman, K. H., Stehouwer, C. D. A., van Kamp, G. J., Dekker, G., Verheugt, F. W. A., & Gooren, L. J. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-6-199303150-00006 · Cited by 339 · see citing works
Orio, F., Palomba, S., Cascella, T., Simone, B. D., Biase, S. D., Russo, T., Labella, D., Zullo, F., Lombardi, G., & Colao, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031867 · Cited by 330 · see citing works
Self-citationJansson, T., Wennergren, M., & Illsley, N. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263141 · Cited by 320 · see citing works
Gonen, Y., & Casper, R. F. (1990) · Journal of In Vitro Fertilization and Embryo Transfer · doi:10.1007/bf01135678 · Cited by 307 · see citing works
Friedler, S. (1996) · Human Reproduction Update · doi:10.1093/humupd/2.4.323 · Cited by 306 · see citing works
Steer, C. V., Campbell, S. C., Tan, S. L., Crayford, T. J. B., Mills, C., MASON, B. A., & Collins, W. P. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54848-1 · Cited by 283 · see citing works
Palomba, S., Orio, F., Falbo, A., Manguso, F., Russo, T., Cascella, T., Tolino, A., Carmina, E., Colao, A., & Zullo, F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0110 · Cited by 279 · see citing works
Self-citationKoçak, M., Çalışkan, E., ŞİMŞİR, Ç., & Haberal, A. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02941-7 · Cited by 267 · see citing works
Elevated Endometrial Androgen Receptor Expression in Women with Polycystic Ovarian Syndrome1
Apparao, K. B. C., Lovely, L. P., Gui, Y., Lininger, R. A., & Lessey, B. A. (2002) · Biology of Reproduction · doi:10.1095/biolreprod66.2.297 · Cited by 265 · see citing works
Decreased uterine perfusion—a cause of infertility
Goswamy, R. K., Williams, G., & Steptoe, P. C. (1988) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136825 · Cited by 252 · see citing works
Growth-Stimulatory Actions of Insulinin Vitroandin Vivo*
Straus, D. S. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-2-356 · Cited by 226 · see citing works
Development, pharmacology and clinical experience with clomiphene citrate
Dickey, R. (1996) · Human Reproduction Update · doi:10.1093/humupd/2.6.483 · Cited by 226 · see citing works
Cermik, D., Selam, B., & Taylor, H. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021072 · Cited by 219 · see citing works
Zaidi, J., Campbell, S. C., Pittrof, R., & Tan, S. L. (1995) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1995.06030191.x · Cited by 195 · see citing works
Sonographic determination of a possible adverse effect of clomiphene citrate on endometrial growth
Gonen, Y., & Casper, R. F. (1990) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137165 · Cited by 193 · see citing works
Chien, L.-W., Au, H., Chen, P., Xiao, J., & Tzeng, C. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03223-5 · Cited by 180 · see citing works
Palomba, S., Orio, F., Nardo, L. G., Falbo, A., Russo, T., Corea, D., Doldo, P., Lombardi, G., Tolino, A., Colao, A., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0689 · Cited by 177 · see citing works
Self-citationDickey, R. P. (1997) · Human Reproduction Update · doi:10.1093/humupd/3.5.467 · Cited by 173 · see citing works
Dickey, R. P., Olar, T. T., Taylor, S. N., Curole, D. N., & Matulich, E. M. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55855-5 · Cited by 171 · see citing works
Kurjak, A., Kupesic‐Urek, S., Schulman, H., & Zalud, I. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54657-3 · Cited by 165 · see citing works
Jakubowicz, D. J., Seppälä, M. T., Jakubowicz, S., Rodriguez-Armas, O., Rivas-Santiago, A., Koistinen, H. K., Koistinen, R., & Nestler, J. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7295 · Cited by 164 · see citing works
Effects of clomiphene citrate on the endometrial thickness and echogenic pattern of the endometrium
Nakamura, Y., Ono, M., Yoshida, Y., Sugino, N., Ueda, K., & Kato, H. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81907-3 · Cited by 161 · cited 2× · see citing works
“The percentage of high-grade endometrial pattern detected in the current study was similar to those obtained by Triwitayakorn et al. (2002) and by Nakamura et al. (1997) in healthy women.”
ResultFischer, G. M., & Swain, M. L. (1977) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1977.232.6.h617 · Cited by 158 · see citing works
Orio, F., Palomba, S., Cascella, T., Simone, B. D., Manguso, F., Savastano, S., Russo, T., Tolino, A., Zullo, F., Lombardi, G., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0965 · Cited by 149 · see citing works
Self-citationHabara, T. (2002) · Human Reproduction · doi:10.1093/humrep/17.1.190 · Cited by 141 · see citing works
Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome
Kashyap, S., Wells, G. A., & Rosenwaks, Z. (2004) · Human Reproduction · doi:10.1093/humrep/deh440 · Cited by 141 · see citing works
The role of color doppler imaging in the diagnosis of polycystic ovary syndrome
Battaglia, C., Artini, P. G., D’Ambrogio, G., Genazzani, A. D., & Genazzani, A. R. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90094-2 · Cited by 139 · see citing works
The role of HOX genes in human implantation
Taylor, H. S. (2000) · Human Reproduction Update · doi:10.1093/humupd/6.1.75 · Cited by 135 · see citing works
Correlation of Endometrial Dating with Basal Body Temperature and Menses
Noyes, R. W., & Haman, J. O. (1953) · Fertility and Sterility · doi:10.1016/s0015-0282(16)31446-7 · Cited by 134 · see citing works
Postmenopausal hormonal replacement decreases plasma levels of endothelin-1.
Ylikorkala, O., Orpana, A., Puolakka, J. O., Pyorala, T., & Viinikka, L. U. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.11.7593457 · Cited by 132 · see citing works
Cacciatore, B., Simberg, N. H., Fusaro, P., & Tiitinen, A. E. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58400-3 · Cited by 123 · see citing works
Steer, C. V., Tan, S. L., MASON, B. A., & Campbell, S. C. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56452-8 · Cited by 115 · see citing works
Quantitation and immunolocalization of glucose transporters in the human placenta
Barrosa, L. F., Yudilevich, D. L., Jarvis, S. M., Beaumont, N. J., & Baldwin, S. A. (1995) · Placenta · doi:10.1016/0143-4004(95)90031-4 · Cited by 100 · see citing works
Aleem, F. A., & Predanić, M. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58145-x · Cited by 94 · see citing works
Fanchin, R. R. F., Righini, C., Ayoubi, J.-M., Olivennes, F. J., de Ziegler, D., & Frydman, R. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00643-9 · Cited by 93 · see citing works
Yaman, C., Ebner, T., Sommergruber, M., Pölz, W., & TEWS, G. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01493-x · Cited by 88 · see citing works
Economos, K., MacDonald, P. C., & Casey, M. L. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.1.1727813 · Cited by 87 · see citing works
Mioni, R., Chiarelli, S. M., Xamin, N., Zuliani, L., Granzotto, M., Mozzanega, B., Maffei, P., Martini, C., Blandamura, S., Sicolo, N., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032028 · Cited by 78 · see citing works
Korgun, E. T., Demir, R., Hammer, A., Dohr, G., Desoyé, G., Skofitsch, G., & Hahn, T. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.5.1364 · Cited by 68 · see citing works
Schwartz, L. B., Chiu, A. S., Courtney, M., Krey, L. C., & Schmidt-Sarosi, C. (1997) · Human Reproduction · doi:10.1093/humrep/12.1.45 · Cited by 65 · see citing works
Palomba, S., Orio, F., Falbo, A., Russo, T., Tolino, A., & Zullo, F. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.021 · Cited by 56 · see citing works
Self-citationPalomba, S., Orio, F., Colao, A. A. L., Carlo, C. D., Sena, T., Lombardi, G., Zullo, F., & Mastrantonio, P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8323 · Cited by 54 · see citing works
Self-citationColor Doppler analysis in lean and obese women with polycystic ovary syndrome
Battaglia, C., Artini, P. G., Genazzani, A. D., Sgherzi, M. R., Salvatori, M., Giulini, S., & Volpe, A. (1996) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1996.07050342.x · Cited by 53 · see citing works
Zaidi, J., Jurkovic, D., Campbell, S. C., Pittrof, R., McGregor, A., & Tan, S. L. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136148 · Cited by 53 · see citing works
Tekay, A., Martikainen, H., & Jouppila, P. (1996) · Human Reproduction · doi:10.1093/humrep/11.2.364 · Cited by 49 · see citing works
Huckabee, W. E. (1962) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(62)90006-6 · Cited by 42 · see citing works
Hock, D. L., Bohrer, M. K., Ananth, C. V., & Kemmann, E. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81509-9 · Cited by 40 · see citing works
AJOSSA, S., Guerriero, S., Paoletti, A. M., Orrù, M., & Melis, G. B. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03101-1 · Cited by 36 · see citing works
Imaging the Endometrium: Are There Predictors of Uterine Receptivity?
Pierson, R. A. (2003) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)30578-3 · Cited by 36 · see citing works
Strowitzki, T., Corleta, H. V. E., Kellerer, M., & Häring, H. U. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55674-x · Cited by 35 · see citing works
Utero-ovarian arterial blood flow and hormonal profile in patients with polycystic ovary syndrome
Bokal, E. V., & Meden‐Vrtovec, H. (1998) · Human Reproduction · doi:10.1093/humrep/13.4.815 · Cited by 33 · see citing works
Color Doppler analysis in oligo-and amenorrheic women with polycystic ovary syndrome
Battaglia, C., Artini, P. G., Genazzani, A. D., Gretnigni, R., Salvatori, M., Sgherzi, M. R., Giulini, S., Lombardo, M., & Volpe, A. (1997) · Gynecological Endocrinology · doi:10.3109/09513599709152520 · Cited by 32 · see citing works
Is ovulation induction still a therapeutic problem in patients with polycystic ovary syndrome?
Palomba, S., Orio, F., Russo, T., Falbo, A. I., Cascella, T., Colao, A. A. L., Lombardi, G., & Zullo, F. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03347527 · Cited by 29 · see citing works
Self-citationBasir, G. S., Lam, T. P. W., Chau, M. T., Ng, E. H. Y., Wai‐Sum, O., & Ho, P. C. (2001) · Human Reproduction · doi:10.1093/humrep/16.10.2114 · Cited by 29 · see citing works
Uterine blood flow. Assessment in an intrauterine insemination program for unexplained infertility.
Tohma, H., Hasegawa, I., Sekizuka, N., & Tanaka, K. (1997) · PubMed · Cited by 21 · see citing works
Expression of glucose transporter 1 in human endometrial and decidual tissue
Strowitzki, T., Capp, E., von Wolff, M., & Müller‐Höcker, J. (2001) · Gynecological Endocrinology · doi:10.1080/gye.15.3.219.224 · Cited by 19 · see citing works
Cacciatore, B., Simberg, N. H., Tiitinen, A. E., & Ylikorkala, O. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81401-x · Cited by 17 · see citing works
Transvaginal ultrasonography and the assessment of luteal phase endometrium
Doherty, C. M., Silver, B., Binor, Z., Molo, M. W., & Radwańska, E. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90680-h · Cited by 16 · see citing works
Endometrial Evaluation in Superovulation Programs: Relationship with Successful Outcome
Tropea, A., Miceli, F., Minici, F., Orlando, M., Lamanna, G., Gangalè, M. F., Catino, S., Lanzone, A., & Apa, R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1335.023 · Cited by 16 · see citing works
Metabolism of Glucose in the Human Endometrium with Special Reference to Fertility and Contraception
Hackl, H. (1973) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347309158301 · Cited by 14 · see citing works
AJOSSA, S., Paoletti, A. M., Guerriero, S., Floris, S., Mannias, M., & Melis, G. B. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00462-2 · Cited by 14 · see citing works
Triwitayakorn, A., Suwajanakorn, S., Triratanachat, S., Sampatanukul, P., Pruksananonda, K., & Sereepapong, W. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03192-8 · Cited by 13 · see citing works
Basal, oxytocin-, and insulin-stimulated glucose oxidation in human endometrium
Truchan, B., Taylor, P. J., Goren, H. J., Lederis, K. P., Hollenberg, M. D., & Okabe, T. (1987) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y87-056 · Cited by 10 · see citing works
Dastidar, K. G., & Dastidar, S. G. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00498-9 · Cited by 5 · see citing works
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Palomba, S., Falbo, A., Zullo, F., & Orio, F. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0030 · Cited by 426 · see citing works
Self-citationEndometrial function in women with polycystic ovary syndrome: a comprehensive review
Palomba, S., Piltonen, T., & Giudice, L. C. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa051 · Cited by 385 · see citing works
Self-citationFertile ground: human endometrial programming and lessons in health and disease
Evans, J., Salamonsen, L. A., Winship, A., Menkhorst, E. M., Nie, G., Gargett, C. E., & Dimitriadis, E. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.116 · Cited by 371 · see citing works
Review: Role of metformin in the management of polycystic ovary syndrome
Lashen, H. (2010) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018810380215 · Cited by 176 · see citing works
A role for menstruation in preconditioning the uterus for successful pregnancy
Brosens, J. J., Parker, M. G., McIndoe, A., Pijnenborg, R., & Brosens, I. A. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.11.037 · Cited by 166 · see citing works
Use of metformin in polycystic ovary syndrome
Mathur, R., Alexander, C. J., Yano, J., Trivax, B., & Azziz, R. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.09.010 · Cited by 146 · see citing works
Cassina, M., Donà, M., Di Gianantonio, E., Litta, P., & Clementi, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu022 · Cited by 143 · see citing works
Pregnancy complications in PCOS
Homburg, R. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.03.009 · Cited by 140 · see citing works
Homburg, R. (2007) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2007.07.009 · Cited by 141 · see citing works
Palomba, S., Falbo, A. I., Orio, F., & Zullo, F. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.087 · Cited by 134 · see citing works
Self-citationPalomba, S., Pasquali, R., Orio, F., & Nestler, J. E. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03369.x · Cited by 98 · see citing works
Self-citationLegro, R. S., Zaino, R. J., Demers, L. M., Kunselman, A. R., Gnatuk, C. L., Williams, N. I., & Dodson, W. C. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.12.025 · Cited by 98 · see citing works
Metformin reduces abortion in pregnant women with polycystic ovary syndrome
Khattab, S., Mohsen, I. A., Foutouh, I. A., Ramadan, A. R., Moaz, M., & Al-Inany, H. G. (2006) · Gynecological Endocrinology · doi:10.1080/09513590601010508 · Cited by 98 · see citing works
Endometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome
Zhang, Y., Hu, M., Meng, F., Sun, X., Xu, H., Zhang, J., Cui, P., Morina, N., Li, X., Li, W., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.023 · Cited by 90 · see citing works
Effect of maternal PCOS and PCOS-like phenotype on the offspring's health
Puttabyatappa, M., Cardoso, R. C., & Padmanabhan, V. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.11.030 · Cited by 86 · see citing works
Palomba, S., Orio, F., Falbo, A. I., Russo, T., Tolino, A., & Zullo, F. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1009 · Cited by 83 · see citing works
Self-citationPalomba, S., Falbo, A. I., & Sala, G. B. L. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-3 · Cited by 78 · see citing works
Self-citationWang, T., Zhang, J., Hu, M., Zhang, Y., Cui, P., Li, X., Li, J., Vestin, E., Brännström, M., Shao, R., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.31425 · Cited by 77 · see citing works
Carvajal, R., Rosas, C., Kohan, K., Gabler, F., Vantman, D., Romero, C., & Vega, M. (2013) · Human Reproduction · doi:10.1093/humrep/det116 · Cited by 74 · see citing works
Shao, R., Li, X., Feng, Y., Lin, J.-F., & Billig, H. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-33-41 · Cited by 66 · see citing works
Palomba, S., Falbo, A. I., Russo, T., Battista, L., Tolino, A., Orio, F., & Zullo, F. (2010) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2010.02525.x · Cited by 61 · see citing works
Self-citationEffects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia
Erdemoğlu, E., Güney, M., Giray, S. G., Take, G., & Mungan, T. (2009) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2009.04.034 · Cited by 53 · see citing works
Use of metformin in the treatment of polycystic ovary syndrome
Genazzani, A. D., Ricchieri, F., & Lanzoni, C. (2010) · Women's Health · doi:10.2217/whe.10.43 · Cited by 51 · see citing works
Effects of testosterone and metformin on glucose metabolism in endometrium
Zhang, L., & Liao, Q. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.096 · Cited by 48 · see citing works
Palomba, S., Orio, F., Falbo, A. I., Russo, T., Tolino, A., & Zullo, F. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.035 · Cited by 45 · see citing works
Self-citationMetformin modulates IL-8, IL-1β, ICAM and IGFBP-1 expression in human endometrial stromal cells
Germeyer, A., Jauckus, J., Zorn, M., Tóth, B., Capp, E., & Strowitzki, T. (2010) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2010.11.006 · Cited by 44 · see citing works
Uterine progesterone signaling is a target for metformin therapy in PCOS-like rats
Hu, M., Zhang, Y., Feng, J., Xu, X., Zhang, J., Zhao, W., Guo, X., Li, J., Vestin, E., Cui, P., et al. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0086 · Cited by 43 · see citing works
Xiong, F., Xiao, J., Bai, Y., Zhang, Y., Li, Q., & Lishuang, X. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.128 · Cited by 41 · see citing works
Endometrial Glucose Transporters in Health and Disease
Vrhovac, I., Karin‐Kujundžić, V., Madunić, J., Šola, I. M., & Šerman, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.703671 · Cited by 34 · see citing works
Palomba, S., Falbo, A., Battista, L., Russo, T., Venturella, R., Tolino, A., Orio, F., & Zullo, F. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.11.042 · Cited by 33 · see citing works
Self-citationAn Update on the Progress of Endometrial Receptivity in Women with Polycystic Ovary Syndrome
Zhao, J., Chen, Q., & Xue, X. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00641-z · Cited by 34 · see citing works
Zheng, J., Shan, P. F., & Gu, W. (2013) · PubMed · doi:10.3275/8932 · Cited by 31 · see citing works
Rafiee, B., Karbalay‐Doust, S., Tabei, K., Azarpira, N., Alaee, S., Lohrasbi, P., & Bahmanpour, S. (2022) · European Journal of Translational Myology · doi:10.4081/ejtm.2022.10409 · Cited by 29 · see citing works
RetractedMohsen, I. A., ElKattan, E. A., Nabil, H., & Khattab, S. (2012) · Journal of Clinical Ultrasound · doi:10.1002/jcu.22006 · Cited by 26 · see citing works
Yuan, L., Wu, H., Huang, W., Bi, Y., Qin, A., & Yang, Y. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00772-7 · Cited by 25 · see citing works
The effects of metformin on uterine tissue of hyperandrogenized BALB/c mice
Elia, E. M., Belgorosky, D., Faut, M., Vighi, S., Pustovrh, M. C., Luigi, D., & Motta, A. B. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap033 · Cited by 25 · see citing works
Ito-Yamaguchi, A., Suganuma, R., 熊耳, 敦., Hashimoto, S., Yoshida‐Komiya, H., & Fujimori, K. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.951321 · Cited by 18 · see citing works
Metformin in the Treatment of Polycystic Ovary Syndrome
Ab, M. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208785294609 · Cited by 18 · see citing works
Insulin-sensitizing agents and reproductive function in polycystic ovary syndrome patients
Palomba, S., Falbo, A. I., Orio, F., & Zullo, F. (2008) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328307ebc5 · Cited by 17 · see citing works
Self-citationMechanisms Involved in Metformin Action in the Treatment of Polycystic Ovary Syndrome
Motta, A. B. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789058101 · Cited by 13 · see citing works
Effect of DHEA and metformin on corpus luteum in mice
Sander, V. A., Facorro, G. B., Piehl, L. L., de Celis, E. R., & Motta, A. B. (2009) · Reproduction · doi:10.1530/rep-08-0325 · Cited by 12 · see citing works
Metformin and polycystic ovary syndrome
Lebinger, T. G. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328089f0ea · Cited by 12 · see citing works
Özçimen, E. E., Üçkuyu, A., Ciftci, F. C., & Zeyneloğlu, H. B. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-008-0904-0 · Cited by 12 · see citing works
Report of the international symposium: polycystic ovary syndrome: first Latin-American consensus
Motta, A. B. (2010) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02259.x · Cited by 12 · see citing works
Gut microbiota in diabetic-linked polycystic ovarian syndrome: Mechanisms and therapeutic insights
Mehta, P., Saha, D., Das, A., & Das, B. K. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.102870 · Cited by 11 · see citing works
Le syndrome des ovaires polykystiques (SOPK)
Torre, A., & Fernandez, H. (2007) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2007.04.002 · Cited by 10 · see citing works
Pregnancy Complications in PCOS
Homburg, R. (2009) · Springer eBooks · doi:10.1007/978-0-387-09718-3_11 · Cited by 10 · see citing works
PCOS from Lifestyle to the Use of Inositol and Insulin Sensitizers
Genazzani, A. D., Prati, A., Despini, G., Marini, G. M. F., & Ricchieri, F. (2014) · ISGE series · doi:10.1007/978-3-319-03494-2_7 · Cited by 7 · see citing works
Metformin and polycystic ovary syndrome.
Omran, M. Y. S. (2007) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Biomaterials as regenerative medicine in Poly Cystic Ovarian Syndrome (PCOS) treatment
Chauhan, N., Peter, A., Soni, S., Rawal, R., & Jain, U. (2022) · Biochemical Engineering Journal · doi:10.1016/j.bej.2022.108649 · Cited by 6 · see citing works
Kutlesic, R. M., Milosavljević, M., Vukomanović, P., & Stefanović, M. (2008) · Vojnosanitetski pregled · doi:10.2298/vsp0810743k · Cited by 6 · see citing works
Birth weight and childhood growth in daughters of women with irregular menstrual cycles
Wang, E. T., Cirillo, P. M., Kao, C., Cohn, B. A., & Cedars, M. I. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2013.788638 · Cited by 6 · see citing works
Meikle, A. W. (2008) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)79202-3 · Cited by 5 · see citing works
Uterine progesterone signaling is a target for metformin therapy in PCOS-like ratsPreprint
Hu, M., Zhang, Y., Feng, J., Xu, X. J., Zhang, J., Zhao, W., Guo, X., Li, J., Vestin, E., Cui, P., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/238261 · Cited by 5 · see citing works
Role of Metformin in Polycystic Ovary Syndrome
Nowak, K., Nowak, K., Olejarz, Z., Drygała, Z., Wyrwał, J., Zielińska, Z., Słowik, M., Nieć, M., Gierlach, K., & Krasuska, M. (2024) · Journal of Education Health and Sport · doi:10.12775/jehs.2024.52.009 · Cited by 4 · see citing works
Functional and Structural Uterine Changes in PCOS
Zaborowska, Ł., Blok, J., Piotrkowicz, E., Lindheim, S. R., & Ludwin, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167921 · Cited by 4 · see citing works
Dafopoulos, K. C., Vrekoussis, T., CHALVATZAS, N., Messini, C. I., Kalantaridou, S., Georgoulias, P., Messinis, I. E., & Makrigiannakis, A. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.1983 · Cited by 3 · see citing works
Metformin ameliorates endometrial thickness in a rat model of thin endometrium
Imran, M. J., Khandvilkar, A., Metkari, S., Sachdeva, G., & Chaudhari, U. K. (2024) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13862 · Cited by 4 · see citing works
Effect of metformin treatment on ovarian stromal blood flow in women with polycystic ovary syndrome
Esmaeel, H. A., EL-Sattar, M. A., EL-Kelany, O., & EL-Halaby, A. E.-D. (2019) · Menoufia Medical Journal · doi:10.4103/mmj.mmj_294_18 · Cited by 3 · see citing works
PCOS and metformin: from pharmacology to clinical use for women's health
Genazzani, A. D., Ricchieri, F., Prati, A., Chierchia, E., Rattighieri, E., Bosco, G., Despini, G., Campedelli, A., Farinetti, A., & Santagni, S. (2012) · IRIS UNIMORE (University of Modena and Reggio Emilia) · Cited by 3 · see citing works
Stracquadanio, M., & Ciotta, L. (2015) · Springer eBooks · doi:10.1007/978-3-319-16760-2_6 · Cited by 3 · see citing works
Is endometrial receptivity impaired in women with polycystic ovary syndrome?
Palomba, S., Falbo, A. I., Marci, R., & Caserta, D. (2022) · Minerva Obstetrics and Gynecology · doi:10.23736/s2724-606x.22.05144-2 · Cited by 4 · see citing works
Self-citationInsulin-Sensitizing Drugs for the Treatment of Infertility in Polycystic Ovary Syndrome
Ryan, C. S., & Nestler, J. E. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-310-3_10 · Cited by 3 · see citing works
Is metformin effective and safe during pregnancy in women with PCOS? An overview of reviews
Palomba, S., Seminara, G., Costanzi, F., Sculli, M. A., Alessi, E., Caserta, D., & Aversa, A. (2025) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2025.2574334 · Cited by 4 · see citing works
Self-citationKhalaf, W. M., Akl, S., & Ramadan, R. R. (2018) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2018.814148 · Cited by 2 · see citing works
The effects of metformin treatment on the ovaries and uterus of offspring
Ayas, B., Kırmızıkan, S., Kocaman, A., & Avcı, B. (2020) · Gynecological Endocrinology · doi:10.1080/09513590.2020.1819002 · Cited by 2 · see citing works
Polycystic Ovary Syndrome: Update on Treatment Options and Treatment Considerations for the Future
Farrell-Turner, K. A. (2011) · Clinical Medicine Insights Women s Health · doi:10.4137/cmwh.s6715 · Cited by 2 · see citing works
Tulay, P., Önal, T., & Vatansever, S. (2021) · Zygote · doi:10.1017/s0967199421000769 · Cited by 2 · see citing works
Effect of metformin on the endometrial proteome of diet-induced obese mice
Malliou-Becher, M.-N., Turnwald, E., Skupin, L., Kretschmer, T., Mesaros, A., Purrio, M., Wohlfarth, M., Handwerk, M., Kalis, S., Gründemann, D., et al. (2025) · Journal of Molecular Endocrinology · doi:10.1530/jme-24-0098 · Cited by 1 · see citing works
Eid, S., & Shakweer, M. (2014) · Clinical Medicine and Diagnostics · Cited by 1 · see citing works
Pregnancy in Polycystic Ovary Syndrome
Homburg, R. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-108-6_20 · Cited by 1 · see citing works
Effective Regimens for Ovulation Induction in Polycystic Ovary Syndrome
Tapanainen, J. S., & Morin-Papunen, L. C. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-108-6_19
Efecto del hiperandrogenismo sobre la fisiología uterina. Acción de la Metformina como tratamiento
Elia, E. M. (2011) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Steck, T. (2007) · Gynäkologische Endokrinologie · doi:10.1007/s10304-007-0181-1
Use of in vitro maturation in a clinical setting: Patient populations and outcomes
Morimoto, Y., Fukuda, A. “., & Satou, M. (2017) · doi:10.1201/9781351228237-17
33. Hypocaloric diets in overweight and obese patients with polycystic ovary syndrome
Palomba, S., Falbo, A. I., & Sala, G. B. L. (2014) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-767-7.033
Self-citationManagement of menstrual disorders and endometrial hyperplasia
Lombardi, G., Stasi, V. D., Volpe, A., Savastano, S., Colao, A., & Orio, F. (2013) · doi:10.2217/ebo.12.195
Self-citationFarshchian, N., Nezhad, S. T., & Kamangar, P. B. (2018) · Australasian Medical Journal · doi:10.21767/amj.2018.3252
The effect of metformin on clinical features of women with polycystic ovary syndrome
Bilibajkić, M., Antić, I. B., & Μacut, D. (2018) · Medicinski podmladak · doi:10.5937/mp69-17816
Implantation and the Fetal Health
Ljubić, A., Abazović, D., Ljubić, D., Pirković, A., & Perovic, A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.87016
Meikle, A. W. (2008) · Yearbook of Medicine · doi:10.1016/s0084-3873(08)79301-5
Use of in vitro maturation in a clinical setting: Patient populations and outcomes
Morimoto, Y., Fukuda, A. “., & Satoh, M. (2012) · Informa Healthcare eBooks · doi:10.3109/9781841849713.011
da Costa, B. V., Paixão, B. F. D. S., Santos, M. D. S., Seabra, M. S. D. M., Nascimento, V. L., Matos, L. F. S., Silva, L. A. S., & Souza, M. T. D. S. (2025) · Cuadernos de Educación y Desarrollo · doi:10.55905/cuadv17n3-079
Huang, S., Chen, S.-R., Chen, W.-H., Zheng, L., Xu, J. Q., Shi, Y., Lin, S., & Shi, Q. (2026) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70249
- Authors
- Palomba, S., Russo, T., Orio, F., Falbo, A., Manguso, F., Cascella, T., Tolino, A., Carmina, E., Colao, A., & Zullo, F.
- Affiliations
- Magna Graecia University (IT)
- University of Naples Federico II (IT)
- Federico II University Hospital (IT)
- Corresponding author
- Palomba, Stefano
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-10-27
- Volume
- 21
- Issue
- 2
- Pages
- 457-465
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2134509388
- Cited by
- 85
- References
- 68
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- metformin, polycystic ovary syndrome, anovulatory infertility, uterine blood flow, endometrial blood flow, endometrial thickness, endometrial receptivity, ovulation induction, reproductive outcomes
- MeSH terms
- Adult, Anovulation, Endometrium, Female, Fertility Agents, Humans, Menstruation-Inducing Agents, Metformin, Polycystic Ovary Syndrome, Regional Blood Flow, Uterus
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