Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum
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We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, ovarian endometriosis exhibits an 8-fold higher expression of aromatase, which suggests that aromatase inhibitors may be particularly active in this form of endometriosis.
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Gene expression levels of CYP19A1 were reported to be highest in OE lesions, followed by peritoneal endometriosis, and DE lesions-in that order.
“Similarly, the gene expression levels of CYP19A1 were reported to be the highest in OE lesions, followed by peritoneal endometriosis, and DE lesions—in that order (Heilier et al., 2006).”
From Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium (2025) · cites this paper as Heilier et al., 2006
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Nisolle, M., & Donnez, J. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00191-x · Cited by 1,279 · see citing works
Aromatase expression in endometriosis.
Noble, L. S., Simpson, E. R., Johns, A., & Bulun, S. E. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.1.8550748 · Cited by 566 · see citing works
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Functional MicroRNA Involved in Endometriosis
Hawkins, S. M., Creighton, C. J., Han, D. Y., Zariff, A., Anderson, M. L., Gunaratne, P. H., & Matzuk, M. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0371 · Cited by 264 · see citing works
Estrogen metabolism and action in endometriosis
Rižner, T. L. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.03.022 · Cited by 153 · see citing works
Šmuc, T., Pucelj, M. R., Šinkovec, J., Husen, B., Thole, H., & Rižner, T. L. (2007) · Gynecological Endocrinology · doi:10.1080/09513590601152219 · Cited by 124 · see citing works
Estrogen biosynthesis and signaling in endometriosis
Huhtinen, K., Ståhle, M., Perheentupa, A., & Poutanen, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.022 · Cited by 107 · see citing works
New biomarkers in endometriosis
(2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2018.12.002 · Cited by 72 · see citing works
Hudelist, G., Czerwenka, K., Keckstein, J., Haas, C., Fink-Retter, A., Gschwantler-Kaulich, D., Kubista, E., & Singer, C. F. (2007) · Reproductive Sciences · doi:10.1177/1933719107309120 · Cited by 70 · see citing works
Nie, J., Yi, Y., Liu, X., & Guo, S.-W. (2025) · Human Reproduction Open · doi:10.1093/hropen/hoaf028 · Cited by 11 · see citing works
De Abreu, L. G., Silveira, V. S., Scrideli, C. A., Ramos, E. S., Dos Reis, R. M., Ferriani, R. A., & De Sá, M. F. S. (2011) · Journal of Endometriosis · doi:10.5301/je.2012.9070 · Cited by 11 · see citing works
- Authors
- Heilier, J.-F., Donnez, O., Van Kerckhove, V., Lison, D., & Donnez, J.
- Affiliations
- UCLouvain (BE)
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Heilier, Jean-François
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 85
- Issue
- 5
- Pages
- 1516-1518
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2030425959
- Cited by
- 37
- References
- 2
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2019: 1 · 2017: 2 · 2016: 3 · 2014: 1 · 2013: 1
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- aromatase, endometriosis, endometrioma, peritoneal endometriosis, rectovaginal septum, adenomyosis, aromatase inhibitors, gene expression
- MeSH terms
- Aromatase, Endometriosis, Female, Humans, Organ Specificity, Ovarian Diseases, Peritoneal Diseases, Rectal Diseases, Tissue Distribution, Vaginal Diseases
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