Functional MicroRNA Involved in Endometriosis
Open accessAbstract
Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility. Although endometriosis is pathologically characterized by endometrial tissue outside the normal uterine location, endometriosis is otherwise not easily explained. Endometriomas, endometriotic cysts of the ovary, typically cause pain and distortion of pelvic anatomy. To begin to understand the pathogenesis of endometriomas, we describe the first transcriptome-microRNAome analysis of endometriomas and eutopic endometrium using next-generation sequencing technology. Using this approach, we generated a total of more than 54 million independent small RNA reads from our 19 clinical samples. At the microRNA level, we found 10 microRNA that were up-regulated (miR-202, 193a-3p, 29c, 708, 509-3-5p, 574-3p, 193a-5p, 485-3p, 100, and 720) and 12 microRNA that were down-regulated (miR-504, 141, 429, 203, 10a, 200b, 873, 200c, 200a, 449b, 375, and 34c-5p) in endometriomas compared with endometrium. Using in silico prediction algorithms, we correlated these microRNA with their corresponding differentially expressed mRNA targets. To validate the functional roles of microRNA, we manipulated levels of miR-29c in an in vitro system of primary cultures of human endometrial stromal fibroblasts. Extracellular matrix genes that were potential targets of miR-29c in silico were significantly down-regulated using this biological in vitro system. In vitro functional studies using luciferase reporter constructs further confirmed that miR-29c directly affects specific extracellular matrix genes that are dysregulated in endometriomas. Thus, miR-29c and other abnormally regulated microRNA appear to play important roles in the pathophysiology of uterine function and dysfunction.
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Ovarian endometriosis evidenced differential expression of miRNAs relative to paired eutopic endometrium in several studies.
“Similar to peritoneal disease, ovarian endometriosis evidenced differential expression of miRNAs relative to paired eutopic endometrium in several studies [122, 123].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [123]
Global differential expression of miRNAs in eutopic compared with ectopic endometrium has been evaluated by several groups.
“Global differential expression of miRNAs in eutopic compared with ectopic endometrium has been evaluated by several groups [120–124].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [123]
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- Authors
- Hawkins, S. M., Creighton, C. J., Han, D. Y., Zariff, A., Anderson, M. L., Gunaratne, P. H., & Matzuk, M. M.
- Affiliations
- Baylor College of Medicine (US)
- University of Houston (US)
- ORCID
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2011-05-01
- Volume
- 25
- Issue
- 5
- Pages
- 821-832
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC3082329
- OpenAlex
- W2074400318
- Cited by
- 264
- References
- 66
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 14 · 2023: 10 · 2022: 22 · 2021: 18 · 2020: 23 · 2019: 24 · 2018: 22 · 2017: 14 · 2016: 19 · 2015: 15 · 2014: 18 · 2013: 24 · 2012: 14
- FWCI
- 21.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54 HD-0077495, R03HD077495, K12HD050128, R01HD032067)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- endometriosis, endometrioma, microRNA, miR-29c, eutopic endometrium, extracellular matrix genes, endometrial stromal fibroblasts, miRNA target prediction, endometriosis pathogenesis, unexplained infertility
- MeSH terms
- Adult, Animals, Endometriosis, Female, Gene Expression Regulation, Genes, Humans, Luciferases, Middle Aged, Down-Regulation, Case-Control Studies, Extracellular Matrix Proteins, Genes, Reporter, Gene Expression Profiling, RNA Interference, MicroRNAs, Mice, Young Adult, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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