The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.
Increased risk of depressive disorders in women with polycystic ovary syndrome
Open accessAbstract
Objective Polycystic ovary syndrome (PCOS) is associated with several metabolic complications. A few small studies have also suggested an increased risk of depression in women with PCOS. The goals of this study were to estimate the prevalence of depressive disorders in women with PCOS compared with controls and to evaluate the correlation between depression, hyperandrogenism, and other metabolic markers.Design Cohort study.Setting University Hospital.Patient(s) Women with PCOS (Rotterdam criteria; n = 103). Women without PCOS seen during the same time period for an annual exam were used as control subjects (n = 103).Intervention(s) Primary Care Evaluation of Mental Disorders Patient Health Questionnaire (PRIME-MD PHQ) and the Beck Depression Inventory.Main outcome measure(s) Depressive disorders.Result(s) Women with PCOS were at an increased risk for depressive disorders (new cases) compared with controls (21% vs. 3%; odds ratio 5.11 [95% confidence interval (CI) 1.26-20.69]; P<.03). The overall risk of depressive disorders in women with PCOS was 4.23 (95% CI 1.49-11.98; P<.01) independent of obesity and infertility. Compared with the nondepressed PCOS subjects, the depressed PCOS subjects had a higher body mass index (BMI) and evidence of insulin resistance (P<.02).Conclusion(s) We report a significantly increased risk of depressive disorders (as defined by the Diagnostic and Statistical Manual IV) in women with PCOS and recommend routine screening in this population.
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“This is concerning given the established evidence of increased depression, anxiety, eating disorders and other mental illnesses in those affected with PCOS [3, 8, 57–59].”
From Challenges in diagnosis and health care in polycystic ovary syndrome in Canada: a patient view to improve health care (2023) · cites this paper as [57]
Experimental — accuracy not yet measuredIn the citing paper
“Women with PCOS are more likely to report fatigue than women without PCOS [59].”
From Providing lifestyle advice to women with PCOS: an overview of practical issues affecting success (2021) · cites this paper as [59]
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Cites
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Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study
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Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219
Utility of a New Procedure for Diagnosing Mental Disorders in Primary Care: The PRIME-MD 1000 Study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.1994.03520220043029 · Cited by 1,873
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Knochenhauer, E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3078 · Cited by 1,134
Cited by
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Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.024 · Cited by 1,976
Legro, R. S., Arslanian, S. A., Ehrmann, D. A., Hoeger, K. M., Murad, M. H., Pasquali, R., & Welt, C. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2350 · Cited by 1,919
Polycystic ovary syndrome: etiology, pathogenesis and diagnosis
Goodarzi, M. O., Dumesic, D. A., Chazenbalk, G., & Azziz, R. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.217 · Cited by 1,488
Epidemiology, diagnosis, and management of polycystic ovary syndrome
Sirmans, S. M., & Pate, K. (2013) · Clinical Epidemiology · doi:10.2147/clep.s37559 · Cited by 1,301
Wild, R. A., Carmina, E., Diamanti-Kandarakis, E., Dokras, A., Escobar-Morreale, H. F., Futterweit, W., Lobo, R., Norman, R. J., Talbott, E., & Dumesic, D. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2724 · Cited by 1,010
Self-citation
Metadata
- Authors
- Hollinrake, E., Abreu, A., Maifeld, M., Van Voorhis, B. J., & Dokras, A.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Dokras, Anuja
- ORCID
- Dokras, Anuja
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 87
- Issue
- 6
- Pages
- 1369-1376
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2150468895
- Cited by
- 631
- References
- 40
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 20 · 2023: 19 · 2022: 16 · 2021: 25 · 2020: 22 · 2019: 29 · 2018: 263 · 2017: 47 · 2016: 16 · 2015: 19 · 2014: 24 · 2013: 15 · 2012: 31
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Iowa Research Online (The University of Iowa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- polycystic ovary syndrome, depressive disorders, depression prevalence, hyperandrogenism, insulin resistance, body mass index, obesity, infertility, depression screening, women's mental health
- MeSH terms
- Adolescent, Adult, Depressive Disorder, Female, Humans, Interpersonal Relations, Middle Aged, Polycystic Ovary Syndrome, Surveys and Questionnaires, Risk Factors, Cohort Studies, Body Mass Index, Odds Ratio
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