Cited by 631Ovarian function and disordersEndometriosis Research and TreatmentMaternal Mental Health During Pregnancy and Postpartum

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Increased risk of depressive disorders in women with polycystic ovary syndrome

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Hollinrake, Elizabeth, Abreu, Alison, Maifeld, Michelle, Van Voorhis, Bradley J., Dokras, Anuja·2007·Fertility and Sterility

DOI 10.1016/j.fertnstert.2006.11.039

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Abstract

Objective Polycystic ovary syndrome (PCOS) is associated with several metabolic complications. A few small studies have also suggested an increased risk of depression in women with PCOS. The goals of this study were to estimate the prevalence of depressive disorders in women with PCOS compared with controls and to evaluate the correlation between depression, hyperandrogenism, and other metabolic markers.Design Cohort study.Setting University Hospital.Patient(s) Women with PCOS (Rotterdam criteria; n = 103). Women without PCOS seen during the same time period for an annual exam were used as control subjects (n = 103).Intervention(s) Primary Care Evaluation of Mental Disorders Patient Health Questionnaire (PRIME-MD PHQ) and the Beck Depression Inventory.Main outcome measure(s) Depressive disorders.Result(s) Women with PCOS were at an increased risk for depressive disorders (new cases) compared with controls (21% vs. 3%; odds ratio 5.11 [95% confidence interval (CI) 1.26-20.69]; P<.03). The overall risk of depressive disorders in women with PCOS was 4.23 (95% CI 1.49-11.98; P<.01) independent of obesity and infertility. Compared with the nondepressed PCOS subjects, the depressed PCOS subjects had a higher body mass index (BMI) and evidence of insulin resistance (P<.02).Conclusion(s) We report a significantly increased risk of depressive disorders (as defined by the Diagnostic and Statistical Manual IV) in women with PCOS and recommend routine screening in this population.

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Validation and Utility of a Self-report Version of PRIME-MD<SUBTITLE>The PHQ Primary Care Study</SUBTITLE>
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Background
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Authors: Hollinrake, E., Abreu, A., Maifeld, M., Van Voorhis, B. J., & Dokras, A.
Affiliations: University of Iowa (US)
Corresponding author: Dokras, Anuja
ORCID: Dokras, Anuja
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2007-06
Volume: 87
Issue: 6
Pages: 1369-1376
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2006.11.039
OpenAlex: W2150468895
Cited by: 631
References: 40
Citations by year: 2026: 13 · 2025: 17 · 2024: 20 · 2023: 19 · 2022: 16 · 2021: 25 · 2020: 22 · 2019: 29 · 2018: 263 · 2017: 47 · 2016: 16 · 2015: 19 · 2014: 24 · 2013: 15 · 2012: 31
FWCI: 12.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Iowa Research Online (The University of Iowa) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords: polycystic ovary syndrome, depressive disorders, depression prevalence, hyperandrogenism, insulin resistance, body mass index, obesity, infertility, depression screening, women's mental health
MeSH terms: Adolescent, Adult, Depressive Disorder, Female, Humans, Interpersonal Relations, Middle Aged, Polycystic Ovary Syndrome, Surveys and Questionnaires, Risk Factors, Cohort Studies, Body Mass Index, Odds Ratio

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Increased risk of depressive disorders in women with polycystic ovary syndrome

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