The influence of sperm morphology on preimplantation genetic diagnosis cycles outcome
Open accessAbstract
Objective To evaluate the impact of abnormal sperm morphology on the rates of aneuploidy, implantation, and clinical pregnancy. Design Retrospective cohort study. Setting University-based IVF center. Patient(s) Fifty-two patients undergoing their first IVF-preimplantation genetic diagnosis (PGD) cycle. Intervention(s) The PGD analysis of embryos. Main outcome measure(s) Patients were divided into two groups based on sperm morphology: teratospermic group (TSG) and normal sperm group (NSG). The primary outcome measures of rates of aneuploidy, implantation, clinical pregnancy rate (PR) per cycle, and clinical PR per embryo transfer were compared between TSG and NSG according to PGD analysis results. Results A higher percentage of normal embryos was seen in the NSG (32%) versus the TSG (20%). Overall, 30% of IVF-PGD cycles had no normal embryos for transfer. The clinical PR per cycle was 44% in the NSG compared to 14% in the TSG (relative risk [RR] = 3.19; 95% confidence interval [CI] 1.1-9.0). A similar trend was noted with the clinical PR per embryo transfer with 57% patients becoming pregnant in the NSG versus 20% patients in the TSG (RR = 2.76; 95% CI 1.2-7.2). Implantation was twice as likely to occur in the NSG as compared to TSG (RR = 2.5; 95% CI 1.1-7.2). Conclusion(s) Rates of euploidy, implantation, clinical PR per cycle, and clinical PR per embryo transfer were higher in the NSG compared to the TSG, suggesting that sperm morphology plays an important role in the outcome of IVF-PGD cycles.
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Pathophysiological studies have shown sometimes controversial associations between sperm morphology and sperm competence (aptitude to undergo the acrosomal reaction, DNA integrity, chromatin condensation, etc.).
“Sperm morphology assessment has also been examined in numerous pathophysiological studies that have shown sometimes controversial associations between morphology and sperm competence (aptitude to undergo the acrosomal reaction, DNA integrity, chromatin condensation, etc.) [5, 6, 7, 8].”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [6]
The Discussion (page not provided) says studies of sperm morphology and chromosomal integrity have reached inconsistent conclusions, supporting the claim’s general point about controversial associations. It does not address the cited examples of acrosomal reaction or chromatin condensation, and its mention of DNA fragmentation does not establish an association with morphology. (LLM, conf=0.85)
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- Authors
- Dubey, A., Dayal, M. B., Frankfurter, D., Balazy, P., Peak, D., & Gindoff, P. R.
- Affiliations
- George Washington University (US)
- Corresponding author
- Dubey, Anil
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 89
- Issue
- 6
- Pages
- 1665-1669
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2134448627
- Cited by
- 34
- References
- 23
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- sperm morphology, teratozoospermia, preimplantation genetic diagnosis, aneuploidy, implantation rate, clinical pregnancy rate, embryo quality, IVF outcomes, embryo transfer
- MeSH terms
- Adult, Aneuploidy, Blastocyst, Embryo, Mammalian, Embryo Transfer, Female, Fertilization in Vitro, Humans, Male, Oocytes, Embryo Implantation, Pregnancy, Spermatozoa, Pregnancy Rate, Preimplantation Diagnosis, Oocyte Retrieval
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