The relationship between isolated teratozoospermia and clinical pregnancy after in vitro fertilization with or without intracytoplasmic sperm injection: a systematic review and meta-analysis
Open accessAbstract
We conducted a systematic review and meta-analysis of data from the literature from the years 1986 to 2009 using teratozoospermia and fertilization or IVF or in vitro fertilization as the keywords. A total of 31 studies were identified, and 4 met the inclusion criteria. Isolated teratozoospermia was not associated with a statistically significantly decreased probability of pregnancy with assisted reproduction.
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Publications examining the impact of morphology on spontaneous pregnancy, intrauterine insemination, and in vitro fertilization reach varying conclusions.
“Despite efforts to standardize methodology for grading sperm morphology, publications examining the impact morphology on spontaneous pregnancy, intrauterine insemination, and in vitro fertilization reach varying conclusions (2, 3, 4, 5, 6, 7, 8, 9, 10).”
From Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria (2022) · cites this paper as [10]
The passage labeled Abstract (page not provided) explicitly describes variable findings about sperm morphology and pregnancy after IVF, attributing some variation to differences in morphology assessment. It does not establish that publications on spontaneous pregnancy or intrauterine insemination reach varying conclusions. (LLM, conf=0.86)
Experimental — accuracy not yet measuredExisting literature shows an inconsistent impact of teratozoospermia on pregnancy outcomes and ART success.
“However, existing literature shows the inconsistent impact of teratozoospermia on pregnancy outcomes and ART success (7,18,19)”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [7]
A later meta-analysis of four studies on outcomes after IVF, with or without ICSI, in couples with isolated teratozoospermia found no significant decrease in the likelihood of pregnancy.
“However, a later meta-analysis of four studies on outcomes after IVF, with or without ICSI, in couples with isolated teratozoospermia found no significant decrease in the likelihood of pregnancy (7).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [7]
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Cites
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Smith, R., Kovac, J., Cajipe, M., Lamb, D., & Lipshultz, L. (2017) · Asian Journal of Andrology · doi:10.4103/1008-682x.189211 · Cited by 66 · see citing works
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Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review
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“However, existing literature shows the inconsistent impact of teratozoospermia on pregnancy outcomes and ART success (7,18,19), and one study found that isolated teratozoospermia was more common in fertile than infertile males (20).”
Baker, K. C., Steiner, A. Z., Hansen, K. R., Barnhart, K. T., Cedars, M. I., Legro, R. S., Diamond, M. P., Krawetz, S. A., Usadi, R., Baker, V. L., et al. (2022) · F&S Reports · doi:10.1016/j.xfre.2022.03.003 · Cited by 14 · see citing works
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- Authors
- Hotaling, J. M., Smith, J. F., Rosen, M., Muller, C. H., & Walsh, T. J.
- Affiliations
- University of Washington (US)
- University of California, San Francisco (US)
- Corresponding author
- Hotaling, James M.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 95
- Issue
- 3
- Pages
- 1141-1145
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2005522751
- Cited by
- 95
- References
- 3
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 4 · 2021: 12 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 10 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- teratozoospermia, clinical pregnancy rate, in vitro fertilization, intracytoplasmic sperm injection, assisted reproduction, male infertility, fertilization rate
- MeSH terms
- Female, Humans, Infertility, Male, Male, Pregnancy, Pregnancy Outcome, Spermatozoa, Sperm Injections, Intracytoplasmic
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