RETRACTED: Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol
Open accessAbstract
Objective To evaluate the outcome of long letrozole therapy for induction of ovulation in patients with clomiphene-resistant polycystic ovary syndrome (PCOS).Design Prospective randomized controlled study.Setting University teaching hospital and a private practice.Patient(s) The study comprised 218 patients with clomiphene-resistant PCOS.Intervention(s) Patients were randomly allocated to treatment with either long letrozole therapy (n = 108; 219 cycles) or short letrozole therapy (n = 110; 225 cycles).Main outcome measure(s) Number of growing and mature follicles, serum E(2) (pg/mL), serum P (ng/mL), endometrial thickness, occurrence of pregnancy and miscarriage.Result(s) The number of ovulating patients was greater in the long letrozole group (65.7% vs. 61.8%), but without statistical differences. The total numbers of follicles during stimulation was significantly greater in the long letrozole group (6.7 +/- 0.3 vs. 3.9 +/- 0.4). The numbers of follicles > or =14 mm and > or =18 mm were significantly greater in the long letrozole group. There was no significant difference in the pretreatment endometrial thickness or endometrial thickness at the time of hCG administration between the two groups. Pregnancy occurred in 28 of 225 cycles in the short group (12.4%) and 38 of 219 cycles (17.4%) in the long letrozole group, and the difference was statistically significant.Conclusion(s) The long letrozole protocol (10 days) can produce more mature follicles and subsequently more pregnancies than the short letrozole therapy (5 days).
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One high-quality RCT with low risk of bias found 10 days of letrozole better than 5 days for pregnancy rate per cycle (P=0.03), with no differences in ovulation rate per patient and miscarriage rate per pregnancy among women with CCR PCOS.
“One high-quality RCT (level II) with low risk of bias found 10 days of letrozole better than 5 days for pregnancy rate per cycle ( P =0.03), with no differences in ovulation rate per patient and miscarriage rate per pregnancy among women with CCR PCOS. 246”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [246]
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- Authors
- Badawy, A., Mosbah, A., Tharwat, A., & Eid, M.
- Affiliations
- Mansoura University (EG)
- Corresponding author
- Badawy, Ahmed
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 92
- Issue
- 1
- Pages
- 236-239
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2041698723
- Cited by
- 45
- References
- 16
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 4 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- letrozole, clomiphene citrate resistance, polycystic ovary syndrome, ovulation induction, folliculogenesis, pregnancy rate, endometrial thickness, miscarriage
- MeSH terms
- Letrozole, Adult, Anovulation, Clomiphene, Drug Resistance, Estrogen Antagonists, Female, Ovarian Follicle, Humans, Nitriles, Ovulation Induction, Parity, Polycystic Ovary Syndrome, Pregnancy, Pregnancy Outcome, Prospective Studies, Triazoles, Treatment Outcome, Treatment Failure, Hyperandrogenism, Aromatase Inhibitors, Young Adult
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