The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial
Open accessAbstract
Objective To evaluate postoperative long-term cyclic and continuous administration of combined oral contraceptive (OC) pills in preventing endometriosis-related pain recurrence.Design Prospective, randomized, controlled trial.Setting Tertiary care university hospital.Patient(s) Three hundred eleven women who underwent laparoscopic excision for symptomatic ovarian endometrioma.Intervention(s) Patients were randomly divided into three groups: nonuser group receiving no therapy, and cyclic user group and continuous user group receiving low-dose, monophasic OC pills for 24 months in either cyclic or continuous administration.Main outcome measure(s) Presence and intensity of dysmenorrhea, dyspareunia, and chronic pelvic pain were assessed by a 10-point visual analogue scale (VAS) at 6, 12, 18, and 24 months postoperatively.Result(s) A significant reduction in recurrence rate and VAS scores for dysmenorrhea was evident in the continuous users versus the other groups at 6 months, and in cyclic users versus nonusers at 18 months postoperatively. No significant differences in recurrence rate and VAS scores for dyspareunia and chronic pelvic pain were demonstrated among the groups. The increase of VAS scores from 6-24 months during the study period for dysmenorrhea, dyspareunia, and chronic pelvic pain was significantly higher in nonusers than in the other groups.Conclusion(s) Long-term postoperative use of OC pills can reduce the frequency and the severity of recurrent endometriosis-related dysmenorrhea.
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“Some studies showed that COCs prevent and reduce frequency and severity of recurrent dysmenorrhea and relapse of endometriosis after surgery [252–256].”
From Hormonal treatments for endometriosis: The endocrine background (2022) · cites this paper as [253]
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In the citing paper
“The continuous use of COCs after conservative surgery is more beneficial than the cyclic use [253, 256, 257].”
From Hormonal treatments for endometriosis: The endocrine background (2022) · cites this paper as [253]
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Citations
Cites
Revised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803
Endometriosis and pelvic pain: epidemiological evidence of the relationship and implications
Fauconnier, A., & Chapron, C. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi029 · Cited by 522 · cited 2×
“Because dysmenorrhea seems related to recurrent microbleeding within the endometriotic implants and the associated inflammation (1), OC pills can be effective by inducing atrophy of the endometrial tissue (9), reducing cell proliferation, and increasing apoptosis in the endometrium (18).”
BackgroundInfluentialLaparoscopic excision of endometriosis: A randomized, placebo-controlled trial
Abbott, J., Hawe, J., Hunter, D., Holmes, M., Finn, P., & Garry, R. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.03.046 · Cited by 502
The impact of endometriosis upon quality of life: a qualitative analysis
Jones, G., Jenkinson, C., & Kennedy, S. (2004) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/01674820400002279 · Cited by 291
Vercellini, P., Frontino, G., De Giorgi, O., Pietropaolo, G., Pasin, R., & Crosignani, P. G. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00794-5 · Cited by 289
Management of ovarian endometriomas
Chapron, C. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.6.591 · Cited by 244
Advances in the management of endometriosis: an update for clinicians
Crosignani, P., Olive, D., Bergqvist, A., & Luciano, A. (2006) · Human Reproduction Update · doi:10.1093/humupd/dmi049 · Cited by 237
Seracchioli, R., Mabrouk, M., Frascà, C., Manuzzi, L., Montanari, G., Keramyda, A., & Venturoli, S. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.052 · Cited by 224
Self-citationVercellini, P., De Giorgi, O., Mosconi, P., Stellato, G., Vicentini, S., & Crosignani, P. G. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02951-x · Cited by 180
Endometriosis: Treatment Strategies
VALLE, R. F., & Sciarra, J. J. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1290.026 · Cited by 151
Cited by
Sorted by citations
Endometriosis: pathogenesis and treatment
Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.255 · Cited by 1,940
Rethinking mechanisms, diagnosis and management of endometriosis
Chapron, C., Marcellin, L., Borghese, B., & Santulli, P. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0245-z · Cited by 1,084
Treatment of pelvic pain associated with endometriosis: a committee opinion
(2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.02.012 · Cited by 397
Systematic review of endometriosis pain assessment: how to choose a scale?
Bourdel, N., Alves, J., Pickering, G. P., Ramilo, I. D. T. M., Roman, H., & Canis, M. J. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu046 · Cited by 378
Hormonal treatments for endometriosis: The endocrine background
Vannuccini, S., Clemenza, S., Rossi, M., & Petraglia, F. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09666-w · Cited by 336
Metadata
- Authors
- Seracchioli, R., Mabrouk, M., Frascà, C., Manuzzi, L., Savelli, L., & Venturoli, S.
- Affiliations
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Corresponding author
- Seracchioli, Renato
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 94
- Issue
- 2
- Pages
- 464-471
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2039313615
- Cited by
- 158
- References
- 20
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 1 · 2022: 4 · 2021: 9 · 2020: 15 · 2019: 7 · 2018: 9 · 2017: 13 · 2016: 8 · 2015: 22 · 2014: 10 · 2013: 14 · 2012: 11
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- oral contraceptives, combined oral contraceptives, endometrioma, endometriosis recurrence, postoperative pain management, laparoscopic resection, dysmenorrhea, dyspareunia, chronic pelvic pain
- MeSH terms
- Adult, Chronic Disease, Contraceptives, Oral, Dysmenorrhea, Dyspareunia, Endometriosis, Female, Humans, Ovarian Diseases, Postoperative Pain, Laparoscopy, Time Factors, Treatment Outcome, Disease-Free Survival, Kaplan-Meier Estimate, Secondary Prevention, Young Adult
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