The effect of aromatase inhibitor letrozole on body mass index, serum hormones, and sperm parameters in infertile men
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We investigated the effect of letrozole, an aromatase inhibitor, on body mass index, serum hormones, and sperm parameters in infertile men with decreased T:E(2) ratios. All sperm parameters increased after letrozole treatment. Letrozole may be effectively used to improve sperm parameters in infertile men with a low serum T:E(2) ratio.
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In three small studies, letrozole or testolactone has been administered to morbidly obese men to improve their testosterone levels.
“In three small studies, letrozole or testolactone has been administered to morbidly obese men to improve their testosterone levels [42-44].”
From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [43]
Treatment with letrozole or testolactone resulted in normalization of testosterone levels in all subjects, with a concomitant suppression of the originally increased levels of estradiol.
“Treatment resulted in normalization of testosterone levels in all subjects, with a concomitant suppression of the originally increased levels of estradiol.”
From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [43]
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Ou, N., Sun, Y., Zhang, J., Liu, S., Zhang, Y., Zhao, J., Bai, H., Li, P., Zhi, E., Huang, Y., et al. (2023) · Andrologia · doi:10.1155/2023/1870530 · Cited by 1 · see citing works
Testosterone to Estradiol Ratios in Fertile and Subfertile Men: A Large Cohort Analysis
Panken, E. J., Hayon, S., Greenberg, D. R., Kumar, S. K. S. R., Brannigan, R. E., & Halpern, J. A. (2024) · Urology · doi:10.1016/j.urology.2024.11.004 · Cited by 1 · see citing works
Male Sexual and Reproductive Health
Tharakan, T., Minhas, S., & Jayasena, C. N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00036-0 · Cited by 1 · see citing works
Guo, B., Li, J. J., Ma, Y., Zhao, Y.-T., & Liu, J. (2021) · Research Square · doi:10.21203/rs.3.rs-1084887/v1 · Cited by 1 · see citing works
Medical Management of Male Infertility
Kovac, J. R. (2023) · Cambridge University Press eBooks · doi:10.1017/9781009197533.014 · Cited by 1 · see citing works
Optimisation médicale du recueil de spermatozoïdes dans les azoospermies non obstructives
Lejeune, H., Lapoirie, M., Brosse, A., Cuzin, B., d’Estaing, S. G., & Plotton, I. (2014) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2014.07.023
Fertility Assessment in the Male
Polackwich, A. S., & Sabanegh, E. S. (2016) · Current clinical urology · doi:10.1007/978-3-319-27711-0_4
Fertility Preservation in Hypogonadal Men
Carrasquillo, R. J., & Ramasamy, R. (2017) · Springer eBooks · doi:10.1007/978-3-319-42396-8_9
The First Visit: Consult and Workup Before Sperm Banking
Polackwich, A. S., & Garcia-Gil, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-42396-8_12
The Role of Hormonal Profiles to Forecast Male Fertility Chances
Kathrins, M. N., & Niederberger, C. (2017) · CRC Press eBooks · doi:10.4324/9781315151632-3
- Authors
- Saylam, B., Efesoy, O., & Çayan, S.
- Affiliations
- Mersin Üniversitesi (TR)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 95
- Issue
- 2
- Pages
- 809-811
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2095031069
- Cited by
- 120
- References
- 12
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 13 · 2023: 9 · 2022: 15 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 5 · 2017: 11 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 8
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- letrozole, aromatase inhibitors, male infertility, semen parameters, body mass index, serum hormone levels, testosterone/estradiol ratio, androgen deficiency
- MeSH terms
- Letrozole, Adult, Estradiol, Hormones, Humans, Infertility, Male, Male, Middle Aged, Nitriles, Spermatozoa, Testosterone, Triazoles, Body Mass Index, Aromatase Inhibitors, Semen Analysis
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