Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios
Open accessAbstract
Objective To compare the effects of 2.5 mg letrozole with those of 1 mg anastrazole daily on the hormonal and semen profiles of a subset of infertile men with low T/E(2) ratios. Design Prospective, nonrandomized study. Setting Reproductive medicine clinic. Patient(s) The study group consisted of 29 infertile men with a low serum T/E(2) ratio (<10). Intervention(s) Patients were divided into two groups. Group A included 15 patients treated with 2.5 mg letrozole orally once daily for 6 months, and Group B consisted of 14 patients treated with 1 mg anastrazole orally every day for 6 months. Main outcome measure(s) Hormonal evaluation included measurement of serum FSH, LH, PRL, T, and E(2). In all sperm analyses pretreatment and posttreatment total motile sperm counts (ejaculate volume × concentration × motile fraction) were evaluated. Result(s) The use of aromatase inhibitors (either letrozole or anastrazole) in cases of infertile men with low T/E(2) ratios improved both hormonal and semen parameters. Conclusion(s) This study suggests that some men with severe oligospermia, low T levels, and normal gonadotropin concentration may have a treatable endocrinopathy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AIs are well-tolerated, but side effects may include nausea, elevation of liver enzymes, headaches, and hot flashes.
“AIs are well-tolerated, but side effects may include nausea, the elevation of liver enzymes, headaches, and hot flashes (71).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [71]
Cites
AROMATASE INHIBITORS FOR MALE INFERTILITY
Raman, J. D., & Schlegel, P. N. (2002) · Journal of Urology · doi:10.1016/s0022-5347(01)69099-2 · Cited by 383 · see citing works
Successful Fertility Treatment for Klinefelter's Syndrome
Ramasamy, R., Ricci, J. A., Palermo, G. D., Gosden, L. V., Rosenwaks, Z., & Schlegel, P. N. (2009) · Journal of Urology · doi:10.1016/j.juro.2009.05.019 · Cited by 325 · see citing works
EVIDENCE OF A TREATABLE ENDOCRINOPATHY IN INFERTILE MEN
PAVLOVICH, C. P., KING, P., GOLDSTEIN, M., & SCHLEGEL, P. N. (2001) · Journal of Urology · doi:10.1016/s0022-5347(05)66540-8 · Cited by 282 · see citing works
Raven, G., de Jong, F. H., Kaufman, J.-M., & de Ronde, W. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0462 · Cited by 134 · see citing works
Saylam, B., Efesoy, O., & Çayan, S. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.09.021 · Cited by 120 · see citing works
Comparative Assessment in Young and Elderly Men of the Gonadotropin Response to Aromatase Inhibition
T’Sjoen, G. G., Giagulli, V. A., Delva, H., Crabbe, P., De Bacquer, D., & Kaufman, J.-M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0982 · Cited by 73 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Frontiers in hormone therapy for male infertility
Khourdaji, I., Lee, H., & Smith, R. P. (2018) · Translational Andrology and Urology · doi:10.21037/tau.2018.04.03 · Cited by 47 · see citing works
Non-testosterone management of male hypogonadism: an examination of the existing literature
Krzastek, S. C., & Smith, R. P. (2020) · Translational Andrology and Urology · doi:10.21037/tau.2019.11.16 · Cited by 34 · see citing works
Novel Therapy for Male Hypogonadism
Carrasquillo, R., Chu, K., & Ramasamy, R. (2018) · Current Urology Reports · doi:10.1007/s11934-018-0816-x · Cited by 31 · see citing works
Efficacy of Non-Testosterone-Based Treatment in Hypogonadal Men: A Review.
Raheem, O. A., Chen, T., Akula, K. P., Greenberg, J., Le, T. V., Chernobylsky, D., Sikka, S. C., & Walsh, T. J. (2021) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2020.08.003 · Cited by 22 · see citing works
- Authors
- Gregoriou, O., Bakas, P., Grigoriadis, C., Creatsa, M., Hassiakos, D., & Creatsas, G.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 98
- Issue
- 1
- Pages
- 48-51
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1978134855
- Cited by
- 93
- References
- 6
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 12 · 2023: 9 · 2022: 13 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- aromatase inhibitors, letrozole, anastrozole, male infertility, oligozoospermia, semen parameters, sperm motility, gonadotropins, endocrine disorders, hypogonadism
- MeSH terms
- Letrozole, Anastrozole, Adult, Estradiol, Hormones, Humans, Infertility, Male, Male, Nitriles, Organ Size, Testis, Testosterone, Triazoles, Aromatase Inhibitors, Semen Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
