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HOXA10 expression is decreased in endometrium of women with adenomyosis
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HOXA10 gene expression is decreased in the secretory phase endometrium of women with adenomyosis. Diminished expression of HOXA10 is a potential mechanism explaining decreased implantation observed in women with adenomyosis.
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“The endometrial transcriptome in women with endometriosis may have shared patterns of dysregulation with other inflammatory conditions such as hydrosalpinx [110] or other estrogen dependent diseases such as leiomyomata, endometrial polyps, or adenomyosis [111, 112].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [112]
In the citing paper
“In addition to menstrual cycle phase, gynecologic conditions other than endometriosis have been shown to influence eutopic endometrial gene and protein expression.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [112]
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“Intensity of HOXA10 nuclear staining is indicated by a value of 0, 1, 2, or 3 (none, weak, moderate, strong), and Pi is the percentage of stained nuclei for each intensity (33, 34).”
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“The same mechanisms may affect decidual/trophoblast invasion in women with adenomyosis, who showed increased expression of MMP-2 and MMP-9, E-cadherin, HOXA-10 and leukemia inhibitory factor (Fischer et al., 2011; Benagiano et al., 2012; Galliano et al., 2015; Fig.”
BackgroundSelf-citationPathogenesis of adenomyosis, an update on molecular mechanisms
Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.016 · Cited by 326
“…implantation-associated factors, such as HOXA10, LIF, MMP2, IL-6, cytochrome P450 and RCAS1, in the eutopic endometrium in women with adenomyosis leads to reduced endometrial receptivity and impaired decidualization (Campo et al., 2012b; Fischer et al., 2011; Xishi et al., 2010; Zhou et al., 2012).”
Endometriosis-associated infertility: From pathophysiology to tailored treatment
Bonavina, G., & Taylor, H. S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1020827 · Cited by 388
Self-citationAdenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 331
Effects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis
Younes, G., & Tulandi, T. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.06.025 · Cited by 272
The Impact of Adenomyosis on Women's Fertility
Harada, T., Khine, Y. M., Kaponis, A. I., Nikellis, T., Decavalas, G., & Taniguchi, F. (2016) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000346 · Cited by 258
“Its expression is necessary for endometrial receptivity, and it is significantly lower in the endometrial stroma of women with adenomyosis compared with fertile controls.(93)”
BackgroundStructural and molecular features of the endomyometrium in endometriosis and adenomyosis
Benagiano, G., Brosens, I., & Habiba, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt052 · Cited by 246
“In a comparative study between women with adenomyosis and hypermenorrhoea or adnexal mass (whose fertility status is not stated) and a control group of fertile women with no adenomyosis who had hysterectomy for prolapse or adnexal mass, the expression of HOXA10 protein was shown to be down-regulated in endometrial str…”
BackgroundInfluentialUterine polyps, adenomyosis, leiomyomas, and endometrial receptivity
Munro, M. G. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.02.008 · Cited by 248
Assessment of endometrial receptivity
Lessey, B. A. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.07.1095 · Cited by 235
Pirtea, P., Cicinelli, E., Nola, R. D., de Ziegler, D., & Ayoubi, J. M. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.12.010 · Cited by 232
Update on biomarkers for the detection of endometriosis
Fassbender, A., Burney, R. O., F. O, D., D’Hooghe, T., & Giudice, L. (2015) · BioMed Research International · doi:10.1155/2015/130854 · Cited by 195
“The endometrial transcriptome in women with endometriosis may have shared patterns of dysregulation with other inflammatory conditions such as hydrosalpinx [110] or other estrogen dependent diseases such as leiomyomata, endometrial polyps, or adenomyosis [111, 112].”
Niu, Z., Chen, Q., Sun, Y., & Feng, Y. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2013.824960 · Cited by 167
“[33], expression of the HOXA10 gene, an established marker of endometrial receptivity, was shown to be decreased in the”
BackgroundCampo, S., Campo, V., & Benagiano, G. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.10.003 · Cited by 158
“, 1999) and recently it has been shown that in women with adenomyosis HOXA10 gene expression is significantly lower during the midsecretory phase compared with fertile controls and diminished expression of HOXA10 is therefore a potential mechanism to explain the decreased implantation observed in women with adenomyosi…”
BackgroundART and uterine pathology: how relevant is the maternal side for implantation?
Galliano, D., Bellver, J., Díaz‐García, C., Simón, C., & Pellicer, A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu047 · Cited by 137
Park, C. W., Choi, M. H., Yang, K. M., & Song, I. O. (2016) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2016.43.3.169 · Cited by 137
“Adenomyosis is associated with several conditions that could interfere with natural conception [1-3].”
BackgroundThe eutopic endometrium in endometriosis: are the changes of clinical significance?
Brosens, I. A., Brosens, J. J., & Benagiano, G. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.01.022 · Cited by 126
“, 2010) as well as in adenomyosis (Fischer et al., 2010) and polycystic ovary syndrome (Cermik et al.”
BackgroundGlobal Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis
Herndon, C. N., Aghajanova, L., Balayan, S., Erikson, D., Barragan, F., Goldfien, G., Vo, K. C., Hawkins, S., & Giudice, L. C. (2016) · Reproductive Sciences · doi:10.1177/1933719116650758 · Cited by 106
“The implication of adenomyosis to fertility is contested but may impair implantation.(1,4) Previous data from several investigators have established that eutopic endometrium is abnormal in patients with endometriosis, another complex and multifactorial condition characterized by ectopic implants of endometrial glands…”
BackgroundEmbryo implantation in the laboratory: an update on current techniques
Ojosnegros, S., Seriola, A., Godeau, A. L., & Veiga, A. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa054 · Cited by 107
Classification and Reporting Systems for Adenomyosis
Munro, M. G. (2019) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2019.11.013 · Cited by 103
“For example, HoxA-10 gene expression, a marker for endometrial receptivity, can be decreased both in the mouse model with experimental adenomyosis (29) and in the secretory phase endometrium of women with adenomyosis(30).”
BackgroundAdenomyosis and Infertility—Review of Medical and Surgical Approaches
Szubert, M., Koziróg, E., Olszak, O., Krygier-Kurz, K., Kaźmierczak, J., & Wilczyński, J. R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031235 · Cited by 99
“a deregulation of leukaemia inhibitory factors (LIF) in uterine flushing fluid during the implantation window has been reported in adenomyosis [5,26,27].”
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“Defective HOXA10 expression has been shown in multiple pathologies correlated to infertility, such as endometriosis, adenomyosis, hydrosalpinx, polycystic ovarian syndrome, and endometriosis (22).”
BackgroundMyomas and Adenomyosis: Impact on Reproductive Outcome
Vlahos, N., Theodoridis, T. D., & Partsinevelos, G. A. (2017) · BioMed Research International · doi:10.1155/2017/5926470 · Cited by 85
“A significant decrease in the expression of HOXA-10 gene during the midluteal phase has been documented in women with adenomyosis [132].”
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Campo, S., Campo, V., & Benagiano, G. (2011) · Obstetrics and Gynecology International · doi:10.1155/2012/786132 · Cited by 83
“This means that proper expression of the maternal Hoxa10 gene is necessary to maintain viability of the preimplantation embryo, and, recently, it has been proven that in women with adenomyosis the expression of Hoxa10 gene is decreased during the secretory phase of the cycle, a possible explanation for the observed lo…”
BackgroundAn update on the pharmacological management of adenomyosis
Streuli, I., Dubuisson, J. B., Santulli, P., de Ziegler, D., Batteux, F., & Chapron, C. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.953055 · Cited by 75
“Studies have shown an over-expression of aromatase P450, a decrease of integrin b3, osteopontin and leukemia inhibiting factor and an impairment of HOXA-10 gene function during the implantation window suggesting an impaired receptivity and blastocyst--endometrium interaction in women with adenomyosis [26-30].”
BackgroundThe Endometrium in Adenomyosis
Benagiano, G., & Brosens, I. A. (2012) · Women s Health · doi:10.2217/whe.12.8 · Cited by 73
Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility
Khan, K. N., Fujishita, A., & Mori, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144057 · Cited by 77
“(iii) Impairment of implantation may result from inflammation, a lack of adequate expression of adhesion molecules (integrins), reduced expression of implantation markers, such as leukemia inhibitory factor (LIF), and altered function of the gene for embryonic development (HOXA10) [185].”
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“HOXA10 gene expression is decreased in the secretory-phase endometrium of women with adenomyosis [7].”
BackgroundDecreased expression of NR4A nuclear receptors in adenomyosis impairs endometrial decidualization
Jiang, Y., Jiang, R., Cheng, X., Zhang, Q., Hu, Y., Zhang, H., Cao, Y., Zhang, M., Wang, J., Ding, L., et al. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw042 · Cited by 53
“Alterations in a number of implantation-associated factors (such as HOXA10, LIF, MMP2, Interleukin-6, Cytochrome P450, and RCAS1) in the eutopic endometrium in women with adenomyosis have been found to result in reduced endometrial receptivity and impaired decidualization (Xiao et al., 2010; Fischer et al., 2011; Camp…”
BackgroundNamiki, T., Ito, J., & Kashiwazaki, N. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12103 · Cited by 52
Kulp, J. L., Mamillapalli, R., & Taylor, H. S. (2016) · Reproductive Sciences · doi:10.1177/1933719116630427 · Cited by 45
“The diseases studied are known to result in decreased expression of HOXA10 in the endometrium.(49) Our findings of increased methylation at certain CpG sites in the promoter of HOXA10 suggest that this methylation correlates with previous reports of decreased HOXA10 gene expression in these diseases.”
BackgroundResultSelf-citationHomeobox genes for embryo implantation: From mouse to human
He, B., Ni, Z., Kong, S., Lu, J., & Wang, H. (2018) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12002 · Cited by 46
Integrative analysis reveals regulatory programs in endometriosis
Yang, H., Kang, K., Cheng, C., Mamillapalli, R., & Taylor, H. S. (2015) · Reproductive Sciences · doi:10.1177/1933719115592709 · Cited by 39
Self-citationSenturk, L. M., & İmamoğlu, M. (2015) · Women s Health · doi:10.2217/whe.15.60 · Cited by 37
Xue, P., Zhou, W., Fan, W., Jiang, J., Kong, C., Zhou, W., Zhou, J., Huang, X., Yang, H., Han, Q., et al. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00872-4 · Cited by 36
“Abnormal expression of HOXA10 and its downstream target genes leading to decreased endometrial receptivity are closely related to female infertility in the patients with gynecological diseases, such as endometriosis [11, 20, 21], adenomyosis [39, 40], and hydrosalpinx [41].”
BackgroundRole of HOXA10 in pathologies of the endometrium
Mishra, A., & Modi, D. N. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-024-09923-8 · Cited by 37
“As compared to controls, there is low expression of HOXA10 in the endometrium of women with adenomyosis [84, 85].”
Juárez‐Barber, E., Segura-Benítez, M., Carbajo‐García, M. C., Bas-Rivas, A., Faus, A., Vidal, C., Gilés, J., Labarta, E., Pellicer, A., Cervelló, I., et al. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.12.008 · Cited by 34
Treatment options and reproductive outcome for adenomyosis-associated infertility
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Wu, Y., Huang, J., Zhong, G., Lan, J., Lin, H., & Zhang, Q. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.10.014 · Cited by 33
Expression of HOXA10 Gene in Women with Endometriosis: A Systematic Review
Lazim, N., Elias, M. H., Sutaji, Z., Karim, A., Abu, M. A., Ugusman, A., Syafruddin, S. E., Mokhtar, M. H., & Ahmad, M. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612869 · Cited by 35
“The downregulation of HOXA10 in women with adenomyosis can also impact the rate of successful implantation [71].”
BackgroundImpaired decidualization of human endometrial stromal cells from women with adenomyosis†
Peng, Y., Jin, Z., Liu, H., & Xu, C. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab017 · Cited by 30
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“Some studies demonstrated that both HOXA10 and LIF gene expression are significantly decreased in women with adenomyosis.(131,132) In contrast, overexpression of IL-6 and cytochrome P450 have been reported in patients with adenomyosis suggesting dysfunctional endometrium.”
BackgroundPeng, Y., Liu, X., Jin, Z., Liu, H., & Xu, C. (2021) · Human Reproduction · doi:10.1093/humrep/deab234 · Cited by 22
Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility
Juárez‐Barber, E., Francés‐Herrero, E., Corachán, A., Vidal, C., Gilés, J., Alamá, P., Faus, A., Pellicer, A., Cervelló, I., & Ferrero, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020219 · Cited by 22
“Patients with adenomyosis experience defective decidualization [51], altered uterine peristaltic activity [52] and endometrial receptivity [53], impaired embryo-maternal communication [54], and delayed pinopode formation, resulting in unsuccessful embryo implantation [55].”
BackgroundGuan, X., Liu, D., Zhou, H., Dai, C., Wang, T., Fang, Y., Jia, Y., & Li, K. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5493 · Cited by 22
“…(HoxA10/11) and leukemia inhibitory factor (LIF) were downregulated in both mice models (16) and the secretory phase endometrium of women with adenomyosis (17), and their dysregulation decreased downstream factors influencing endometrial receptivity by repressing the target gene integrin β 3 (18).”
Pier, B. D., Crellin, C., Katre, A. K., Conner, M., Novak, L., Young, S. L., & Arend, R. C. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00056-x · Cited by 22
Wu, H., Tsai, T.-C., Liu, S.-M., Pai, A. H.-Y., & Chen, L.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168937 · Cited by 21
“In addition, subendometrial myometrium (inner myometrium or junctional zone) presents with dysfunctional hyperperistalsis and increased intrauterine pressure in women with adenomyosis, amplified by local hyperestrogenism, leading to defective implantation and placentation and, in turn, miscarriages…”
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Determining the Molecular Background of Endometrial Receptivity in Adenomyosis
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“…associated with subfertility in patients of reproductive age, with infertility being attributed to several factors, such as impaired endometrial receptivity, poor maternal immune status, a prethrombotic state, and other unexplained causes (Fischer et al. 2011; Campo et al. 2012; Zhou et al. 2012).”
BackgroundInfluentialHu, L., Li, H., Huang, C., Chen, H., Zhu, G., & Qian, K. X. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.05.036 · Cited by 13
Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis
He, B., Teng, X., Hao, F., Zhao, M., Chen, Z.-Q., Li, K., & Yan, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.928024 · Cited by 13
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Jensen, A., Nielsen, M. L., Guleria, S., Kjær, S. K., Heitmann, B. L., & Kesmodel, U. S. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.09.017 · Cited by 11
“Supported by a grant to B.L.H. by the Danish Council for Strategic Research (11-116213) and by internal funding from the Danish Cancer Society.”
BackgroundZhang, M., Zhang, Q., Cao, Z., Cai, X., Liu, J., Jiang, Y., Zhu, Y., Zhou, J., Yu, L., Zhen, X., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01203-1 · Cited by 10
Is adenomyosis a problem in reproduction and fertility?
Korzekwa, A. J., Łupicka, M., Socha, B. M., Mannelli, C., & Skarzynski, D. J. (2014) · Polish Journal of Veterinary Sciences · doi:10.2478/pjvs-2014-0028 · Cited by 12
Ismail, A., Agban, M. N., Hasanein, A. S., Rayan, A. A., & Abbas, A. M. (2017) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2017.05.004 · Cited by 9
Effects of pretreatment strategies on fertility outcomes in patients with adenomyosis
Moawad, G., Youssef, Y., Fruscalzo, A., Khedhri, S., Faysal, H., Pirtea, P., Guani, B., Vallée, A., Ayoubi, J. M., & Féki, A. (2024) · Frontiers in Reproductive Health · doi:10.3389/frph.2024.1484202 · Cited by 10
Receptivity-based uterine fibroid surgery: an updated systematic review of the evidence
Çelik, Ö., Koç, Ö., Yurci, A., Erşahin, A., Çelik, N., Çağiran, F. T., GÜRKAN, N., Özyurt, R., Özçil, M. D., Duran, B., et al. (2022) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog4905114 · Cited by 8
“Despite rare studies claiming the opposite view, it has been reported that the expression of some genes involved in re-ceptivity such as glycodelin, homeobox, leukemia inhibitor factor, has-miR-504-5p are impaired in the presence of fi-broid, endometriosis, adenomyosis, or hydrosalpinx [4–7].”
BackgroundÇelik, Ö., Çelik, N., GÜNGÖR, N. D., Çelik, S., Arslan, L., Morciano, A., & Tinelli, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214201 · Cited by 8
Trinchant, R., Cruz, M., & Requena, A. (2022) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14256 · Cited by 9
Chu, L.-H., Liao, C.-C., Liew, P., Chen, C.-W., Su, P., Wen, K., Lai, H.-C., Huang, R., & Chen, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115973 · Cited by 8
“The dysfunction of a group of implantation-associated factors, such as HOXA10 and LIF, was identified in the eutopic endometrium in adenomyosis and led to low endometrial receptivity and subsequent infertility [11,12].”
BackgroundEffect of adenomyosis on implantation
Vila-Vives, J. M., Martínez-Conejero, J. A., & Pellicer, A. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.02.005 · Cited by 8
The Art of Managing Infertile Patients with Adenomyosis
Pai, A. H.-Y., Chen, L.-H., Huang, S., Wu, H., Chang, C., Huang, H.-Y., Soong, Y., & Lee, C. (2024) · Gynecology and Minimally Invasive Therapy · doi:10.4103/gmit.gmit_53_24 · Cited by 7
“[10] In addition, current research has found reduced number of luminal microvilli, impaired steroid hormone metabolism, and increased oxidative stress in the endometrium of patients with adenomyosis.”
Trinchant, R., Cruz, M., Requena, A., & García-Velasco, J. A. (2024) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.16082 · Cited by 9
“27 These changes can undermine the embryo's ability to secure itself adequately, leading to potential implantation failure and affecting later stages of pregnancy.”
Alizadeh, Z., Faramarzi, S., Saidijam, M., Alizamir, T., Esna‐Ashari, F., Shabab, N., & Sanoee, M. F. (2013) · Europe PMC (PubMed Central) · Cited by 7
Zhang, S., He, H. R., Wang, J., Ma, L., Wei, X., Zhang, M., & Guo, Y. C. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1548737 · Cited by 5
mRNA and miRNA Biomarkers for Endometriosis
Aghajanova, L., Burney, R. O., Tran, N. D., & Giudice, L. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-59856-7_9 · Cited by 7
Recent Advances and Current Perspectives on Endometrial Receptivity
Bakkensen, J. B., Agarwal, R., & Shapiro, M. (2021) · Current Obstetrics and Gynecology Reports · doi:10.1007/s13669-021-00313-4 · Cited by 6
The Mutation of the Ap3b1 Gene Causes Uterine Hypoplasia in Pearl Mice
Jing, R., Kong, Y., Han, G., Zhang, J., Li, K., Dong, X., Yan, J. R., Zhang, H., Han, J., & Feng, L. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00006-7 · Cited by 6
Kiani, M., Salehi, M., Mogheiseh, A., Mohammadi‐Yeganeh, S., & Shahidi, S. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00240-4 · Cited by 6
“TheHoxa10 gene is one of the miR16-1 target genes that may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment [75, 76].”
BackgroundAberrant Hoxa10 gene methylation as a mechanism for endosulfan-induced implantation failures in rats
Milesi, M. M., Lorenz, V., & Varayoud, J. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111576 · Cited by 6
Khan, K. N. (2024) · Journal of physiological investigation. · doi:10.4103/ejpi.ejpi-d-24-00032 · Cited by 4
Duan, J., Zhou, X., Zhu, H., Zhou, M., Liu, M., Zhou, Y., Li, W., Xu, B., & Zhang, A. (2025) · Molecular Medicine · doi:10.1186/s10020-024-01054-9 · Cited by 4
“Research indicates that patients with adenomyosis show no significant changes in the oocyte (Horton et al. 2019), suggesting that decreased endometrial receptivity is the primary cause of infertility in AM, as confirmed by multiple studies (Munro 2019; Pirtea et al. 2021; Fischer et al. 2011).”
Adénomyose et implantation : mise au point
Yazbeck, C. M., Falcone, S., Ballout, A., Gauché-Cazalis, C., Epelboin, S., Patrat, C., & Luton, D. (2015) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2015.09.001 · Cited by 4
Apelin-13 modulates the endometrial transcriptome of the domestic pig during implantation
Dobrzyń, K., Kieżun, M., Kopij, G., Zarzecka, B., Gudelska, M., Kisielewska, K., Zaobidna, E. A., Makowczenko, K. G., Dall’Aglio, C., Kamiński, T., et al. (2024) · BMC Genomics · doi:10.1186/s12864-024-10417-9 · Cited by 4
“The drop of HOXA10 gene expression was also observed in women with adenomyosis and a decreased rate of proper implantation [45] The presence of this transcription factor was also confirmed in pigs, in both, the endometrium and conceptuses, and its expression raised during the peri-implantation…”
BackgroundChapron, C., Parpex, G., den Bosch, T. V., Hend, A. A., Gargiulo, A., Stockwell, E., Taylor, H., McCarus, S. D., & Petraglia, F. (2026) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2026.105642 · Cited by 4
Self-citationLópez-Luna, A., Hernández-Melchor, D., Ramírez-Martínez, L., & López‐Bayghen, E. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80452 · Cited by 5
Tjahyadi, D., Pribadi, A., Ar, R. S. D., Shofiatun, N. A., & Djuwantono, T. (2022) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2022.104620 · Cited by 3
“There is a relationship between adenomyosis and disruption of the natural process of conception [4,5].”
BackgroundYu, R., Wei, C., Li, G., Ouyang, J., Liu, N., Gu, N.-H., Lin, Y., & Xu, H. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167526 · Cited by 2
Etrusco, A., Riemma, G., Chiantera, V., Laganà, A. S., Agrifoglio, V., Donna, M. C. D., Pecorino, B., Scibilia, G., Tinelli, A., Malvası, A., et al. (2025) · Gynecologic and Obstetric Investigation · doi:10.1159/000543836 · Cited by 3
“Similar to the previous uterine conditions, patients with adenomyosis exhibit reduced levels of HOXA10 [144 – 146] and LIF [147, 148].”
Exome-Based Identification of Candidate Genes in Sporadic Adenomyosis Cases
Tuncer, F. N., Eser, N., Aydin, S., Selçuki, N. F. T., Özaydın, İ. Y., & Oral, E. (2025) · Diagnostics · doi:10.3390/diagnostics15233069 · Cited by 2
“Studies have observed that HOXA10 gene expression is significantly downregulated in the endometrium of women with both adenomyosis and endometriosis [19,20].”
Yang, Q., Zheng, X., Zhong, F., Chen, L., Hong, J., Liu, X., & Jiang, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1488866 · Cited by 2
“Previous studies suggest that the downregulation of HOXA10, NR4A receptor, and FOXO1A appears to impaired implantation in women with AM (50, 51), and dysregulation of LIF has a similar effect (52).”
The Endometrium in Adenomyosis
Habiba, M. A., & Benagiano, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-13012-5_6 · Cited by 2
Metadata
- Authors
- Fischer, C. P., Kayisili, U., & Taylor, H. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Taylor, Hugh S.
- ORCID
- Taylor, Hugh S.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 95
- Issue
- 3
- Pages
- 1133-1136
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC3053130
- OpenAlex
- W2165954066
- Cited by
- 133
- References
- 53
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 18 · 2023: 6 · 2022: 17 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 4
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD052668, R01HD036887)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- HOXA10, adenomyosis, endometrium, luteal phase, gene expression, implantation failure, endometrial receptivity
- MeSH terms
- Homeobox A10 Proteins, Adult, Biopsy, Endometriosis, Endometrium, Female, Humans, Immunohistochemistry, Infertility, Female, Middle Aged, Embryo Implantation, Case-Control Studies, Homeodomain Proteins
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