The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.
HOXA10 expression is decreased in endometrium of women with adenomyosis
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HOXA10 gene expression is decreased in the secretory phase endometrium of women with adenomyosis. Diminished expression of HOXA10 is a potential mechanism explaining decreased implantation observed in women with adenomyosis.
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“The endometrial transcriptome in women with endometriosis may have shared patterns of dysregulation with other inflammatory conditions such as hydrosalpinx [110] or other estrogen dependent diseases such as leiomyomata, endometrial polyps, or adenomyosis [111, 112].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [112]
Experimental — accuracy not yet measuredIn the citing paper
“In addition to menstrual cycle phase, gynecologic conditions other than endometriosis have been shown to influence eutopic endometrial gene and protein expression.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [112]
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Citations
Cites
Effect of endometriosis on in vitro fertilization
Barnhart, K. T., Dunsmoor-Su, R. F., & Coutifaris, C. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03112-6 · Cited by 805 · cited 1×
“Women with endometriosis have lower implantation rates (42).”
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Self-citationThe elusive adenomyosis of the uterus—revisited
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“Approximately 35% of women with adenomyosis are asymptomatic (4).”
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Aberrant integrin expression in the endometrium of women with endometriosis
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“Intensity of HOXA10 nuclear staining is indicated by a value of 0, 1, 2, or 3 (none, weak, moderate, strong), and Pi is the percentage of stained nuclei for each intensity (33, 34).”
Taylor, H. S., Vanden Heuvel, G. B., & Igarashi, P. (1997) · Biology of Reproduction · doi:10.1095/biolreprod57.6.1338 · Cited by 463 · cited 1×
“In endometriosis, a condition commonly seen with adenomyosis, HOXA10 expression does not increase normally during the midsecretory phase (15).”
Self-citationTaylor, H. S., Arici, A. M., Olive, D. L., & Igarashi, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1597 · Cited by 420
Self-citationHOX gene expression is altered in the endometrium of women with endometriosis
Taylor, H. S. (1999) · Human Reproduction · doi:10.1093/humrep/14.5.1328 · Cited by 376 · cited 1×
“Decreased expression of HOXA10 during the midsecretory phase of themenstrual cycle is seen in other conditions associatedwith impaired implantation, such as PCOS, submucosal uterine leiomyomas, hydrosalphinx, and endometriosis (28, 29, 30, 31, 35).”
Self-citationEndocrine Regulation of HOX Genes
Daftary, G. S., & Taylor, H. S. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0018 · Cited by 344
Self-citationWu, Y., Halverson, G., Basir, Z., Strawn, E., Yan, P., & Guo, S.-W. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.01.034 · Cited by 283 · cited 1×
“In endometriosis we and other investigators have recently described an epigenetic change mediated through methylation of the HOXA10 promoter (32, 35, 49).”
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Block, K., Kardana, A., Igarashi, P., & Taylor, H. S. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.9.1101 · Cited by 260
Self-citationBalen, A. H., Tan, S. L., MacDougall, J., & Jacobs, H. S. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138174 · Cited by 257 · cited 1×
“Women with PCOS have lower pregnancy rates (PR) and increased miscarriage rates (36, 37).”
Rackow, B. W., & Taylor, H. S. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.029 · Cited by 239 · cited 2×
“Decreased expression of HOXA10 during the midsecretory phase of themenstrual cycle is seen in other conditions associatedwith impaired implantation, such as PCOS, submucosal uterine leiomyomas, hydrosalphinx, and endometriosis (28, 29, 30, 31, 35).”
Self-citationHydrosalpinx reduces in-vitro fertilization/embryo transfer pregnancy rates
Strandell, A., Waldenström, U., Nilsson, L., & Hamberger, L. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138606 · Cited by 230
Altered expression of HOXA10 in endometriosis: potential role in decidualization
Kim, J. J., Taylor, H. S., Lu, Z., Ladhani, O., Hastings, J. M., Jackson, K. S., Wu, Y., Guo, S. W., & Fazleabas, A. T. (2007) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gam005 · Cited by 228 · cited 2×
“In endometriosis we and other investigators have recently described an epigenetic change mediated through methylation of the HOXA10 promoter (32, 35, 49).”
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Bergholt, T., Eriksen, L., Berendt, N., Jacobsen, M., & Hertz, J. B. (2001) · Human Reproduction · doi:10.1093/humrep/16.11.2418 · Cited by 227
The endometrium as a cause of implantation failure
Sharkey, A., & Smith, S. K. (2003) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/s1521-6934(02)00130-x · Cited by 226
Cermik, D., Selam, B., & Taylor, H. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021072 · Cited by 220 · cited 2×
“Decreased expression of HOXA10 during the midsecretory phase of themenstrual cycle is seen in other conditions associatedwith impaired implantation, such as PCOS, submucosal uterine leiomyomas, hydrosalphinx, and endometriosis (28, 29, 30, 31, 35).”
Self-citationAlteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation
Bagot, C. N., Troy, P. J., & Taylor, H. S. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301245 · Cited by 220
Self-citationAdenomyosis: symptoms, histology, and pregnancy terminations
Levgur, M. (2000) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(99)00659-6 · Cited by 209
Uterine adenomyosis in the infertility clinic
Devlieger, R. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg010 · Cited by 206
Lee, B., Du, H., & Taylor, H. S. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.070391 · Cited by 204 · cited 2×
“Immunohistochemical analysis of HOXA10 expression was performed as previously described (32).”
Self-citationPotential biochemical markers of uterine receptivity
Giudice, L. C. (1999) · Human Reproduction · doi:10.1093/humrep/14.suppl_2.3 · Cited by 189
Leukemia Inhibitory Factor and Human Embryo Implantation
Aghajanova, L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1335.020 · Cited by 180
Direct Regulation of 3-Integrin Subunit Gene Expression by HOXA10 in Endometrial Cells
Daftary, G. S., Troy, P. J., Bagot, C. N., Young, S. L., & Taylor, H. S. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.3.0792 · Cited by 176
Self-citationImani, B., Eijkemans, M. J. C., Velde, E. R. T., Habbema, J. D. F., & Fauser, B. C. J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5705 · Cited by 149 · cited 1×
“Women with PCOS have lower pregnancy rates (PR) and increased miscarriage rates (36, 37).”
Myometrial zonal differentiation and uterine junctional zone hyperplasia in the non-pregnant uterus
Brosens, J. J. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.496 · Cited by 148 · cited 1×
“Alternatively, it may result from dislocation of basal endometrium into myometrium due to dysfunctional uterine hyperperistalsis and/or dysfunctional contractility of the subendometrial myometrium (7).”
Adenomyosis—A Result of Disordered Stromal Differentiation
Parrott, E. L., Butterworth, M., Green, A. R., White, I. N. H., & Greaves, P. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61733-6 · Cited by 143 · cited 1×
“The etiology of adenomyosis is poorly understood; however, traditionally it is thought that adenomyosis results from the abnormal growth of basal endometrium into subendometrial myometrium (5).”
Regulation of HOXA-10 and its expression in normal and abnormal endometrium
Gui, Y., Zhang, J., Yuan, L., & Lessey, B. A. (1999) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/5.9.866 · Cited by 139
Why does hydrosalpinx reduce fertility?: The importance of hydrosalpinx fluid
Strandell, A. (2002) · Human Reproduction · doi:10.1093/humrep/17.5.1141 · Cited by 136
The role of HOX genes in human implantation
Taylor, H. S. (2000) · Human Reproduction Update · doi:10.1093/humupd/6.1.75 · Cited by 134 · cited 1×
“HOXA10 is up-regulated in response to estrogen (E) and P and its levels increase dramatically during the midsecretory phase in the glands (14, 21).”
Self-citationTranscriptional Repression of Peri-Implantation EMX2 Expression in Mammalian Reproduction by HOXA10
Troy, P. J., Daftary, G. S., Bagot, C. N., & Taylor, H. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.1-13.2003 · Cited by 132
Self-citationBagot, C. N., Kliman, H. J., & Taylor, H. S. (2001) · Developmental Dynamics · doi:10.1002/dvdy.1209 · Cited by 128
Self-citationSalpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx
Daftary, G. S., Kayisli, U. A., Seli, E. U., Bükülmez, O., Arici, A. M., & Taylor, H. S. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.06.041 · Cited by 107 · cited 1×
“In the endometrium of women with hydrosalpinges, HOXA10 mRNA was significantly reduced compared with matched fertile controls (29, 38).”
Self-citationKim, J. J., Buzzio, O. L., Li, S., & Lu, Z. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.043182 · Cited by 98
Sarno, J. L., Kliman, H. J., & Taylor, H. S. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0817 · Cited by 98 · cited 1×
“HOXA10 is up-regulated in response to estrogen (E) and P and its levels increase dramatically during the midsecretory phase in the glands (14, 21).”
Self-citationThe Role of HOX Genes in Human Implantation
Kwon, H. E., & Taylor, H. S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1335.001 · Cited by 88
Self-citationXiao, Y., Sun, X., Yang, X., Zhang, J., Xue, Q., Cai, B., & Zhou, Y. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.012 · Cited by 85
Vavilis, D., Αγοραστός, Θ., Tzafettas, J. M., LOUFOPOULOS, A., Vakiani, M., Constantinidis, T., Patsiaoura, K., & Bontis, J. N. (1997) · PubMed · Cited by 82
Hydrosalpinx fluid diminishes endometrial cell HOXA10 expression
Daftary, G. S., & Taylor, H. S. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03306-x · Cited by 78 · cited 2×
“Decreased expression of HOXA10 during the midsecretory phase of themenstrual cycle is seen in other conditions associatedwith impaired implantation, such as PCOS, submucosal uterine leiomyomas, hydrosalphinx, and endometriosis (28, 29, 30, 31, 35).”
Self-citationKim, M. D., Kim, N. K., Kim, H. J., & Lee, M. H. (2005) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-004-8236-3 · Cited by 70 · cited 1×
“Reproductive outcomes improve after successful treatment of adenomyosis with multiple modalities, including hormonal therapy and conservative surgical therapy (9, 10).”
Sharpe-Timms, K. L. (2000) · Human Reproduction · doi:10.1093/humrep/15.10.2180 · Cited by 59 · cited 1×
“Intensity of HOXA10 nuclear staining is indicated by a value of 0, 1, 2, or 3 (none, weak, moderate, strong), and Pi is the percentage of stained nuclei for each intensity (33, 34).”
Adenomyosis and Its Variance: Adenomyoma and Female Fertility
Wang, P., Su, W.-H., Sheu, B., & Liu, W. (2009) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/s1028-4559(09)60295-3 · Cited by 57 · cited 1×
“Reproductive outcomes improve after successful treatment of adenomyosis with multiple modalities, including hormonal therapy and conservative surgical therapy (9, 10).”
Haines, B. P., Voyle, R. B., & Rathjen, P. D. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.4.1369 · Cited by 48
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Pleiotropic effects of Hoxa10 on the functional development of peri‐implantation endometrium
Daftary, G. S., & Taylor, H. S. (2003) · Molecular Reproduction and Development · doi:10.1002/mrd.20013 · Cited by 45 · cited 1×
“HOXA10 has diverse effects on several aspects of adult endometrial development, such as stromal decidualization, leukocyte infiltration, and pinopod development (17, 23).”
Self-citationTaylor, H. S., Daftary, G. S., & Selam, B. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00985-3 · Cited by 29
Self-citationEfficient Liposome-Mediated Gene Transfection and Expression in the Intact Human Uterus
Daftary, G. S., & Taylor, H. S. (2001) · Human Gene Therapy · doi:10.1089/10430340152677458 · Cited by 28 · cited 1×
“Furthermore, gene transfection of the human uterus has been succesfully performed, thus we hypothesize that in the future targeted intrauterine gene therapy may be a technique to improve suboptimal implantation in womenwith adenomyosis (51).”
Self-citationHOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1
Du, H., Sarno, J. L., & Taylor, H. S. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.083980 · Cited by 28
Self-citation
Research works printed but not linked: 1
- Bagot, 2000, Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation, Gene Ther, 7, 1378, 10.1038/sj.gt.3301245 · DOI
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Vannuccini, S., Clifton, V. L., Fraser, I. S., Taylor, H. S., Critchley, H., Giudice, L. C., & Petraglia, F. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv044 · Cited by 379
“The same mechanisms may affect decidual/trophoblast invasion in women with adenomyosis, who showed increased expression of MMP-2 and MMP-9, E-cadherin, HOXA-10 and leukemia inhibitory factor (Fischer et al., 2011; Benagiano et al., 2012; Galliano et al., 2015; Fig.”
BackgroundSelf-citationPathogenesis of adenomyosis, an update on molecular mechanisms
Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.016 · Cited by 326
“…implantation-associated factors, such as HOXA10, LIF, MMP2, IL-6, cytochrome P450 and RCAS1, in the eutopic endometrium in women with adenomyosis leads to reduced endometrial receptivity and impaired decidualization (Campo et al., 2012b; Fischer et al., 2011; Xishi et al., 2010; Zhou et al., 2012).”
Endometriosis-associated infertility: From pathophysiology to tailored treatment
Bonavina, G., & Taylor, H. S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1020827 · Cited by 388
Self-citationAdenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 331
Metadata
- Authors
- Fischer, C. P., Kayisili, U., & Taylor, H. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Taylor, Hugh S.
- ORCID
- Taylor, Hugh S.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 95
- Issue
- 3
- Pages
- 1133-1136
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC3053130
- OpenAlex
- W2165954066
- Cited by
- 133
- References
- 53
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 18 · 2023: 6 · 2022: 17 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 4
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD052668, R01HD036887)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- HOXA10, adenomyosis, endometrium, luteal phase, gene expression, implantation failure, endometrial receptivity
- MeSH terms
- Homeobox A10 Proteins, Adult, Biopsy, Endometriosis, Endometrium, Female, Humans, Immunohistochemistry, Infertility, Female, Middle Aged, Embryo Implantation, Case-Control Studies, Homeodomain Proteins
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