CoChat
Sign Up
Cited by 73Hormonal and reproductive studiesHypothalamic control of reproductive hormonesSperm and Testicular Function

Comparative Assessment in Young and Elderly Men of the Gonadotropin Response to Aromatase Inhibition

T’Sjoen, Guy G., Giagulli, Vito A., Delva, Hans, Crabbe, Patricia, De Bacquer, Dirk, Kaufman, Jean-Marc·2005·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-0982
Open this paper in CoChat — free account

Abstract

CONTEXT: Aging in men is associated with a decline in serum testosterone (T) levels. OBJECTIVE: Our objective was to assess whether decreased T in aging might result from increased estradiol (E2) negative feedback on gonadotropin secretion. DESIGN AND SETTING: We conducted a comparative intervention study (2004) in the Outpatient Endocrinology Clinic, Ghent University Hospital. PARTICIPANTS: Participants included healthy young and elderly men (n = 10 vs. 10). INTERVENTIONS: We used placebo and letrozole (2.5 mg/d) for 28 d, separated by 2 wk washout. MAIN OUTCOME MEASURES: We assessed changes in serum levels of free E2, LH, and FSH, free T, SHBG, and gonadotropins response to an i.v. 2.5-microg GnRH bolus. RESULTS: As assessed after 28 d of treatment, letrozole lowered E2 by 46% in the young men (P = 0.002) and 62% in the elderly men (P < 0.001). In both age groups, letrozole, but not placebo, significantly increased LH levels (339 and 323% in the young and the elderly, respectively) and T (146 and 99%, respectively) (P value of young vs. elderly was not significant). Under letrozole, peak LH response to GnRH was 152 and 52% increase from baseline in young and older men, respectively (P = 0.01). CONCLUSIONS: Aromatase inhibition markedly increased basal LH and T levels and the LH response to GnRH in both young and elderly men. The observation of similar to greater LH responses in the young compared with the elderly does not support the hypothesis that increased restraining of LH secretion by endogenous estrogens is instrumental in age-related decline of Leydig cell function.

Integrity signals

Registry

Crossref · 10.1210/jc.2005-0982

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • AIs have been shown to raise testosterone levels in hypogonadal men and are orally administered.

    “These compounds have been shown to raise testosterone levels in hypogonadal men and are also orally administered (64-66).”

    From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [64]

  • All adult aromatase-deficient men have unfused epiphyses leading to linear growth into adulthood and above-average body length.

    “All adult aromatase-deficient men demonstrated a remarkably low bone mass and unfused epiphyses leading to linear growth into adulthood and above-average body length.”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [23]

  • All adult aromatase-deficient men demonstrated a remarkably low bone mass.

    “All adult aromatase-deficient men demonstrated a remarkably low bone mass and unfused epiphyses leading to linear growth into adulthood and above-average body length.”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [23]

  • Once treated with estradiol, epiphyses closed in most aromatase-deficient men.

    “Once treated with estradiol, epiphyses closed, BMD increased and disturbances in the lipid profile improved in most of these patients.”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [23]

  • Once treated with estradiol, BMD increased in most aromatase-deficient men.

    “Once treated with estradiol, epiphyses closed, BMD increased and disturbances in the lipid profile improved in most of these patients.”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [23]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
T’Sjoen, G. G., Giagulli, V. A., Delva, H., Crabbe, P., De Bacquer, D., & Kaufman, J.-M.
Affiliations
Ghent University Hospital (BE)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2005-10
Volume
90
Issue
10
Pages
5717-5722
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-0982
OpenAlex
W2154436997
Cited by
73
References
38
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 5 · 2013: 4 · 2012: 3
FWCI
1.64
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
aromatase inhibition, letrozole, male aging, testosterone, LH response, estradiol negative feedback, GnRH stimulation, Leydig cell function, gonadotropins, free testosterone, sex hormone-binding globulin
MeSH terms
Letrozole, Adult, Aged, Aged, 80 and over, Aging, Double-Blind Method, Enzyme Inhibitors, Estradiol, Gonadotropins, Humans, Male, Nitriles, Triazoles, Cross-Over Studies, Feedback, Physiological, Aromatase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review