Clinical characteristics indicating adenomyosis coexisting with leiomyomas, a retrospective, questionnaire-based study
Open accessAbstract
Objective To elucidate the clinical profile of a concomitant diagnosis of adenomyosis in women with leiomyomas.Design Retrospective questionnaire-based study.Setting Academic medical center.Patient(s) The study sample comprised a total of 560 women: 159 women with adenomyosis and leiomyomas and 401 women with leiomyomas alone.Intervention(s) Mailing of a symptom questionnaire.Main outcome measure(s) Comparison of women undergoing hysterectomy with adenomyosis and leiomyomas and women with leiomyomas alone.Result(s) Women with a concomitant diagnosis of adenomyosis and leiomyomas had significantly higher scores for disease burden during the menstrual period before surgery: heavy bleeding episodes and passing blood clots. Furthermore, women with adenomyosis and leiomyomas reported higher scores of distress regarding pelvic pain occurring during the menstrual period and pelvic pain not associated with the menstrual cycle. Moreover, in multivariate analysis, older age (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.04-1.18), gravidity (OR 1.44, 95% CI 1.12-1.74), and pelvic pain occurring during the menstrual period (OR 1.27, 95% CI 1.06-1.54) increase the odds of having adenomyosis and not only leiomyomas.Conclusion(s) Adenomyosis contributes to symptomatology in women with concomitant adenomyosis and leiomyomas.
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In women with leiomyomas, those with both leiomyomas and adenomyosis are older than those with leiomyomas alone.
“Even in women with leiomyomas, women with both leiomyomas and adenomyosis are reported to be older than those with leiomyomas alone [24].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [24]
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The Pathogenesis of Adenomyosis vis-à-vis Endometriosis
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“Even in women with leiomyomas, women with both leiomyomas and adenomyosis are reported to be older than those with leiomyomas alone [24].”
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- Authors
- Brucker, S. Y., Huebner, M., Wallwiener, M., Stewart, E. A., Ebersoll, S., Schoenfisch, B., & Taran, F. A.
- Affiliations
- Universitäts Frauenklinik (DE)
- Heidelberg University (DE)
- Mayo Clinic (US)
- Corresponding author
- Taran, Florin A.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 101
- Issue
- 1
- Pages
- 237-241.e1
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2075217182
- Cited by
- 50
- References
- 25
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 10 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 3 · 2018: 3 · 2016: 2 · 2015: 4 · 2014: 2
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-04-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- adenomyosis, uterine fibroids, menstrual bleeding, menorrhagia, pelvic pain, hysterectomy, risk factors, gravidity, age
- MeSH terms
- Adult, Female, Humans, Leiomyoma, Middle Aged, Surveys and Questionnaires, Retrospective Studies, Uterine Neoplasms, Adenomyosis
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