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Cited by 213Endometriosis Research and TreatmentUterine Myomas and TreatmentsGynecological conditions and treatments

Risk factors for adenomyosis

Parazzini, F., Vercellini, P., Panazza, S., Chatenoud, L., Oldani, S., Crosignani, P. G.·1997·Human Reproduction
DOI 10.1093/humrep/12.6.1275
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Abstract

In order to analyse risk factors for adenomyosis, 707 consecutive women who underwent hysterectomy between January 1993 and June 1994 at the Clinica Luigi Mangiagalli, Milan, Italy, were interviewed before surgery by trained physicians. Information on the presence of adenomyosis was obtained from pathologic records. Out of the 707 women, adenomyosis was identified in 150 subjects (21.2%). Women who smoked tended to be at decreased risk of the condition: in comparison with women who had never smoked, the risk for current smokers was 0.7 (0.3-1.3) and the risk decreased with number of cigarettes smoked per day, the odds ratios being 0.8 and 0.6 respectively in women reporting fewer than 10 and more than 10 cigarette smoked per day (chi2 trend 3.57, P = 0.06). The frequency of adenomyosis was higher in parous women: in comparison with nulliparae, the odds ratio of the disease were 1.8 [95% confidence interval (CI) 0.9-3.4] and 3.1 (95% CI 1.7-5.5) respectively in women reporting one and two or more births (chi2 trend 20.71, P < 0.01). Likewise, women reporting one or more spontaneous abortions had an odds ratio of 1.7 (95% CI 1.1-2.6) for adenomyosis, in comparison with those reporting no spontaneous abortion.

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Crossref · 10.1093/humrep/12.6.1275

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14 of 14 references verified0 citation errors · 0 not checkable

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  • Histologically proven adenomyosis at hysterectomy has been linked to multiparity.

    “The primary observation regarding the prevalence of adenomyosis and fecundity has linked histologically proven adenomyosis at the time of hysterectomies to multiparity (34,35).”

    From Endometrial receptivity in adenomyosis and/or endometriosis (2023) · cites this paper as [34]

  • A history of dilatation and curettage (D&C) procedures is a risk factor for adenomyosis.

    “A preponderance of evidence suggests that a history of receiving dilatation and curettage (D&C) procedures is a risk factor for adenomyosis [19,20,21,22].”

    From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [19]

  • The EMID model is consistent with published data showing increased risk of adenomyosis in women with a history of D&C or in multiparous women.

    “The model also seems to be consistent with published data, i.e., an increased risk of adenomyosis in women with a history of D&C or in multiparous women [19,20,21,22].”

    From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [19]

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Authors
Parazzini, F., Vercellini, P., Panazza, S., Chatenoud, L., Oldani, S., & Crosignani, P. G.
Affiliations
  • University of Milan (IT)
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
  • Mario Negri Institute for Pharmacological Research (IT)
ORCID
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
1997-06-01
Volume
12
Issue
6
Pages
1275-1279
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/12.6.1275
OpenAlex
W2125696112
Cited by
213
References
14
Citations by year
2026: 8 · 2025: 2 · 2024: 11 · 2023: 9 · 2022: 19 · 2021: 16 · 2020: 18 · 2019: 10 · 2018: 13 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 15 · 2013: 5 · 2012: 7
FWCI
2.35
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
adenomyosis, risk factors, smoking, parity, miscarriage, hysterectomy, women's health
MeSH terms
Abortion, Spontaneous, Adult, Endometriosis, Female, Humans, Hysterectomy, Italy, Middle Aged, Parity, Pregnancy, Risk Factors, Smoking, Odds Ratio

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