Effects of localization of uterine adenomyosis on clinical features and pregnancy outcome
Open accessAbstract
The purpose of this study was to implore the association among clinical features, long-term fertility outcomes and the anatomical location of adenomyosis identified by ultrasound. We collected data of non-pregnant patients between 20 and 40 years old who had undergone surgical exploration for benign gynecological conditions at our institution between January 2010 and December 2017. A total of 158 women met the inclusion criteria and were allocated into three groups according to the ultrasound-determined adenomyosis anatomical location: anterior (Group A), posterior (Group B), both posterior and anterior (Group C). 44.3% (70/158) adenomyosis was located at the posterior side. History of miscarriage and parity were significantly higher in Group C (p = 0.036 and 0.001 respectively). Group C also had a higher concurrence rate of ovarian endometrioma (OEM) (80.4%, p = 0.002), pelvic adhesion (80.4%, P = 0.003) and the revised American Fertility Society (rAFS) Score (median64, range2-100, P < 0.001), while a significantly lower rate of concurrent peritoneal endometriosis (P = 0.01). Group B showed a relative higher rate of coexistent heavy menstrual bleeding (28.6%, p = 0.04) and oviduct obstruction (24.3%, P = 0.038). Group A had a higher proportion of coexistent leiomyoma (53.1%, P = 0.002). There were no significant differences between group A, B, and C in terms of pain symptoms, endometrial polyps, operation time, and endometriosis fertility index score and other basic characters (p > 0.05). During the follow-up, 59.2% (61/103) patients had clinical pregnancies, and 26.2% (16/61) of them experienced pregnancy loss. Total in vitro fertilization and embryo transfer pregnancy rate was 64.6% (42/65) and spontaneous pregnancy rate was 50.0% (19/38). The Kaplan-Meier curves demonstrated significant lower cumulative pregnancy rate in Group C than Group A and Group B (p = 0.01). Severe obstetric complications such as placenta previa, placenta accreta, preeclampsia, and preterm birth were only found in women with adenomyosis located in the posterior side. In conclusion, types of adenomyosis based on sonographic location had different clinical features and pregnancy outcome. Patients with adenomyosis lesion in both anterior and posterior sides had higher combination of OEM, pelvic adhesion and rAFS score.
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An association between AM of the posterior uterine wall and placenta praevia has been demonstrated.
“An association between AM of the posterior uterine wall and placenta praevia has been demonstrated and posterior adhesions may be a risk factor for bleeding complications [33].”
From Women with Endometriosis—Who Is at Risk for Complications Associated with Pregnancy and Childbirth? A Retrospective Case–Control Study (2024) · cites this paper as [33]
Women with placenta praevia and DIE in the posterior compartment with known adhesions are at risk of bleeding complications.
“Women with placenta praevia and DIE in the posterior compartment with known adhesions are at risk of bleeding complications.”
From Women with Endometriosis—Who Is at Risk for Complications Associated with Pregnancy and Childbirth? A Retrospective Case–Control Study (2024) · cites this paper as [33]
Posterior adhesions may be a risk factor for bleeding complications.
“An association between AM of the posterior uterine wall and placenta praevia has been demonstrated and posterior adhesions may be a risk factor for bleeding complications [33].”
From Women with Endometriosis—Who Is at Risk for Complications Associated with Pregnancy and Childbirth? A Retrospective Case–Control Study (2024) · cites this paper as [33]
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- Authors
- Shi, J., Wu, Y., Li, X., Gu, Z., Zhang, C., Yan, H., Dai, Y., & Leng, J.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Leng, Jinhua
- Venue
- Scientific Reports
- Published
- 2023-09-07
- Volume
- 13
- Issue
- 1
- Pages
- 14714-14714
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC10485030
- OpenAlex
- W4386528869
- Cited by
- 20
- References
- 45
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 10
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Key Research and Development Program of China (2017YFC1001200)
- National Natural Science Foundation of China (82071628)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- uterine adenomyosis, anatomical localization, pregnancy outcomes, fertility, endometrioma, pelvic adhesions, peritoneal endometriosis, menorrhagia, leiomyoma, miscarriage, IVF-ET, cumulative pregnancy rate, pregnancy complications, Endometriosis Fertility Index
- MeSH terms
- Abortion, Spontaneous, Adult, Endometriosis, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Premature Birth, Young Adult, Adenomyosis
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