Laparoscopy vs. Robotic Surgery for Endometriosis (LAROSE): a multicenter, randomized, controlled trial
Open accessAbstract
Objective To determine whether the use of the robot for surgical treatment of endometriosis is better than traditional laparoscopy in terms of operative length, perioperative parameters, and quality of life outcomes. Design Multicenter, randomized clinical trial. Setting University teaching hospitals. Patient(s) Women aged >18 years with suspected endometriosis who elected to undergo surgical management. Intervention(s) Randomization to conventional or robot-assisted laparoscopic removal of endometriosis. Main outcome measure(s) The primary outcome measured was operative time. Secondary outcomes were perioperative complications and quality of life. Result(s) The mean operative time for robotic vs. laparoscopic surgery for endometriosis was 106.6 ± 48.4 minutes vs. 101.6 ± 63.2 minutes. There were no differences in blood loss, intraoperative or postoperative complications, or rates of conversion to laparotomy in the two arms. Both groups reported significant improvement on condition-specific quality of life outcomes at 6 weeks and 6 months. Conclusion(s) There were no differences in perioperative outcomes between robotic and conventional laparoscopy. Clinical trial registration number NCT01556204.
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The results of the first RCT comparing RAS and conventional laparoscopy for endometriosis excision confirm the findings of previous observational studies.
“The results of the first RCT comparing RAS and conventional laparoscopy for endometriosis excision (Soto et al., 2017) confirm the findings of previous observational studies (Berlanda et al., 2017).”
From When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement (2019) · cites this paper as Soto et al., 2017
No significant differences were observed between RAS and conventional laparoscopy for endometriosis excision in terms of operative time, complications, and clinical outcomes at 1-year follow-up.
“In fact, no significant differences were observed between the two surgical approaches in terms of operative time, complications, and clinical outcomes at 1-year follow-up.”
From When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement (2019) · cites this paper as Soto et al., 2017
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Robotic Surgery and Deep Infiltrating Endometriosis Treatment: The State of Art
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Is It the Best Option? Robotic Surgery for Endometriosis
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To Robot or Not To Robot: The Use of Robotics in Benign Gynecologic Surgery
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Cosmetic Outcome of Robotic Surgery Compared to Laparoscopic Surgery for Benign Gynecologic Disease
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Self-citationRobotic Surgery for Bladder Endometriosis: A Systematic Review and Approach
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Gastrointestinal and Genitourinary Complications of Gynecologic Laparoscopic Surgery
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Evidence on Serum Anti-Müllerian Hormone Levels and Endometriosis Surgery
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- Authors
- Soto, E., Luu, T. H., Liu, X., Magrina, J. F., Wasson, M. N., Einarsson, J. I., Cohen, S. L., & Falcone, T.
- Affiliations
- Cleveland Clinic (US)
- Mayo Clinic in Arizona (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Falcone, Tommaso
- ORCID
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 107
- Issue
- 4
- Pages
- 996-1002.e3
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2589501886
- Cited by
- 137
- References
- 30
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 18 · 2023: 25 · 2022: 20 · 2021: 14 · 2020: 13 · 2019: 15 · 2018: 7 · 2017: 1 · 2014: 2
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cleveland Clinic
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, robot-assisted laparoscopic surgery, conventional laparoscopy, operative time, perioperative complications, conversion to open surgery, blood loss, quality of life, endometriosis surgery
- MeSH terms
- Adult, Endometriosis, Female, Hospitals, University, Humans, Laparoscopy, Postoperative Complications, Prospective Studies, Quality of Life, Time Factors, United States, Blood Loss, Surgical, Treatment Outcome, Operative Time, Conversion to Open Surgery, Robotic Surgical Procedures
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