Incidence of endometriosis by study population and diagnostic method: the ENDO study
Open accessAbstract
Objective To estimate the incidence of endometriosis in an operative cohort of women seeking clinical care and in a matched population cohort to delineate more fully the scope and magnitude of endometriosis in the context of and beyond clinical care.Design Matched-exposure cohort design.Setting Surgical centers in the Salt Lake City, Utah, and San Francisco, California, areas.Patient(s) The operative cohort comprised 495 women undergoing laparoscopy/laparotomy between 2007 and 2009, and the population cohort comprised 131 women from the surgical centers' catchment areas.Intervention(s) None.Main outcome measure(s) Incidence of endometriosis by diagnostic method in the operative cohort and by pelvic magnetic resonance imaged (MRI) disease in the population cohort.Result(s) Endometriosis incidence in the operative cohort ranged by two orders of magnitude by diagnostic method: 0.7% for only histology, 7% for only MRI, and 41% for visualized disease. Endometriosis staging was skewed toward minimal (58%) and mild disease (15%). The incidence of MRI-diagnosed endometriosis was 11% in the population cohort.Conclusion(s) Endometriosis incidence is dependent on the diagnostic method and choice of sampling framework. Conservatively, 11% of women have undiagnosed endometriosis at the population level, with implications for the design and interpretation of etiologic research.
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All MRI images in the population cohort were double read, first by the initial and subsequently by a second radiologist.
“All images were double read, first by the initial and subsequently by a second radiologist.2”
From Examining the co-occurrence of endometriosis and polycystic ovarian syndrome (2023) · cites this paper as [2]
Prevalence estimates of endometriosis differ based on the study setting or diagnostic criteria.
“However, prevalence estimates differ based on the study setting or diagnostic criteria. 21”
From Risk of cardiovascular outcomes among women with endometriosis in the United Kingdom: a retrospective matched cohort study (2021) · cites this paper as [21]
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- Authors
- Buck Louis, G. M., Hediger, M. L., Peterson, C. M., Croughan, M., Sundaram, R., Stanford, J., Chen, Z., Fujimoto, V. Y., Varner, M. W., Trumble, A., & Giudice, L. C.
- Affiliations
- National Institutes of Health (US)
- University of Utah (US)
- University of California, San Francisco (US)
- ORCID
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 96
- Issue
- 2
- Pages
- 360-365
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC3143230
- OpenAlex
- W2072785765
- Cited by
- 309
- References
- 27
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 22 · 2023: 14 · 2022: 25 · 2021: 25 · 2020: 34 · 2019: 21 · 2018: 25 · 2017: 25 · 2016: 16 · 2015: 14 · 2014: 13 · 2013: 13 · 2012: 18
- FWCI
- 15.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NO1-DK-6-3428, 10001406-02, NO1‐DK‐6‐3427)
- National Institute of Child Health and Human Development (NO1-DK-6-3427, NO1-DK-63428, 10001406-02)
- Ethicon Endo-Surgery
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (Z01HD008829)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, incidence, diagnostic methods, pelvic MRI, histology, laparoscopy, endometriosis staging, surgical patients
- MeSH terms
- Adult, Biopsy, Endometriosis, Female, Humans, Magnetic Resonance Imaging, Laparoscopy, Predictive Value of Tests, Severity of Illness Index, United States, Cohort Studies, Epidemiologic Research Design, Incidence
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