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Cited by 146Endometriosis Research and TreatmentOvarian function and disordersReproductive Biology and Fertility

Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study

Open access
Kasapoglu, Isil, Ata, Baris, Uyaniklar, Ozlem, Seyhan, Ayse, Orhan, Adnan, Yildiz Oguz, Sule, Uncu, Gurkan·2018·Fertility and Sterility
DOI 10.1016/j.fertnstert.2018.03.015
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Abstract

Objective To evaluate whether endometrioma is associated with a progressive decline in ovarian reserve, and to compare the rate of decline with natural decline in ovarian reserve. Design Prospective, observational study. Setting Tertiary university hospital, endometriosis clinic. Patient(s) Forty women with endometrioma and 40 age-matched healthy controls. Intervention(s) Women with endometriomas who did not need hormonal/surgical treatment at the time of recruitment and were expectantly managed. Controls were age-matched, healthy women. All participants underwent serum antimüllerian hormone (AMH) testing twice, 6 months apart. Sexually active patients with endometrioma also underwent antral follicle count. Main outcome measure(s) Change in serum AMH levels. Result(s) Median (25th-75th percentile) serum AMH level at recruitment was 2.83 (0.70-4.96) ng/mL in the endometrioma group and 4.42 (2.26-5.57) ng/mL in the control group. The median percent decline in serum AMH level was 26.4% (11.36%-55.41%) in the endometrioma group and 7.4% (-11.98%, 29.33%) in the control groups. Twenty-two women with endometrioma who had antral follicle count (AFC) had median AFC of 10 (8-12) at recruitment and 8 (6.3-10) at 6 months. Conclusion(s) Women with endometrioma experience a progressive decline in serum AMH levels, which is faster than that in healthy women. Clinical trial registration number NCT02438735.

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  • Women with endometriosis demonstrate reduced serum AMH relative to control subjects.

    “Women with endometriosis demonstrate reduced serum AMH relative to control subjects (Dong et al., 2019; Kasapoglu et al., 2018; Muzii et al., 2018; Romanski et al., 2019; Sánchez‐Ferrer et al., 2019; Shebl et al., 2009).”

    From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Kasapoglu et al., 2018

    The Results report lower serum AMH in women with endometriomas than in healthy controls at recruitment (2.83 versus 4.42 ng/mL; P=.04) and at six months (1.86 versus 3.2 ng/mL; P=.002). The study examined women with endometriomas, so it does not establish the comparison for women with endometriosis more generally. (LLM, conf=0.88)

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  • Women with endometriosis who do not undergo surgery also show accelerated declines in AMH levels relative to unaffected women.

    “Women with endometriosis treated with ovarian surgery demonstrate an especially steep decline in AMH levels, but women with endometriosis who do not undergo surgery also show accelerated declines in AMH levels relative to unaffected women (Goodman et al., 2016; Kasapoglu et al., 2018; Muzii et al., 2018; Romanski et al., 2019).”

    From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Kasapoglu et al., 2018

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Research works printed but not linked: 29

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Cited by

Sorted by citations

Authors
Kasapoglu, I., Ata, B., Uyaniklar, O., Seyhan, A., Orhan, A., Yildiz Oguz, S., & Uncu, G.
Affiliations
Bursa Uludağ Üni̇versi̇tesi̇ (TR)
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2018-07
Volume
110
Issue
1
Pages
122-127
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2018.03.015
OpenAlex
W2808892623
Cited by
146
References
3
Citations by year
2026: 10 · 2025: 26 · 2024: 16 · 2023: 20 · 2022: 13 · 2021: 31 · 2020: 18 · 2019: 9 · 2018: 1
FWCI
15.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Bursa Uludag University - AVESIS (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords
endometrioma, ovarian reserve, anti-Müllerian hormone, antral follicle count, endometriosis, ovarian reserve decline
MeSH terms
Adult, Endometriosis, Female, Ovarian Follicle, Humans, Infertility, Female, Longitudinal Studies, Ovary, Prospective Studies, Time Factors, Ultrasonography, Biomarkers, Down-Regulation, Case-Control Studies, Disease Progression, Anti-Mullerian Hormone, Ovarian Reserve

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