Assisted reproductive technology use in the United States: a population assessment
Open accessAbstract
Objective To study social and demographic differentiation of assisted reproduction technology (ART) use at the population level in the United States.Design Population-based study.Setting Not applicable.Patient(s) Women 15-49 years old in the American Community Survey and National Vital Statistics Birth Certificate data from 2010-2017.Interventions Not applicable.Main outcome measure(s) Birth rate after ART by major sociodemographic categories and likelihood of having an ART birth.Result(s) Net of education, age, period, and marital status, the incidence rates of ART births are lower for black women (0.57 times; 95% CI, 0.52-0.62) and Hispanic women (0.67 times; 95% CI, 0.57-0.62) relative to white women's rates; for Asian women, the incidence rates are 1.21 times that of white women's rates. Further, the incidence rates of ART births are higher for women with more than a 4-year degree (2.08 times; 95% CI, 1.90-2.27) relative to women with a 4-year degree, and are lower for women with less education. Women who are married have an incidence rate of ART that is 5.72 times (95% CI, 5.37-6.09) that of unmarried women. The incidence rates for 2013-2016 are statistically significantly higher than for 2010 by a factor of 1.16 (95% CI, 1.02-1.31), 1.16 (95% CI, 1.03-1.31), 1.27 (95% CI, 1.12-1.43), and 1.51 (95% CI, 1.43-1.82), respectively. The educational differences in ART exist across all age groups from 20 to 49, but are the largest among the 35-39 and 40-44 age groups.Conclusion(s) Large differences in the risk of an ART birth and the proportion of births and the total fertility rate due to ART exist across period, age, race, education, and marital status groups in the United States. Current measures of ART births may disguise an unmet need for ART.
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The use of assisted reproductive technology may have contributed to the elevated maternal mortality observed in this study among older women.
“its use may have contributed to the elevated maternal mortality observed in our study among older women”
From Age-related disparities in national maternal mortality trends: A population-based study (2025) · cites this paper as [44]
The Results (Age-specific Fertility Rates; page not available) show that the proportion of births attributable to ART increased, particularly among older women. The paper measures ART births, not maternal mortality, and does not assess whether ART contributed to the elevated mortality observed in the citing study. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn the US, assisted reproductive technology has been associated with an elevated risk of maternal mortality.
“In the US, ART has been associated with an elevated risk of maternal mortality [43, 44]”
From Age-related disparities in national maternal mortality trends: A population-based study (2025) · cites this paper as [44]
The Main Outcome Measure(s) and Results sections address ART birth rates and who has ART births, not maternal mortality. Searches of our copy for “maternal mortality” and “maternal death risk” found no passage assessing an association between ART and maternal mortality in the US. (LLM, conf=0.75)
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Cites
Integrated Public Use Microdata Series
Ruggles, S., Genadek, K., Goeken, R., Grover, J., & Sobek, M. (2015) · Institute for Social Research and Data Innovation · doi:10.18128/d010.v6.0 · Cited by 1,487 · see citing works
Integrated Public Use Microdata Series: Version 7.0
Ruggles, S., Genadek, K. R., Goeken, R., Grover, J., & Sobek, M. (2017) · Institute for Social Research and Data Innovation · doi:10.18128/d010.v7.0 · Cited by 577 · see citing works
Fertility Treatments and Multiple Births in the United States
Kulkarni, A. D., Jamieson, D. J., Jones, H. W., Kissin, D. M., Gallo, M. F., Macaluso, M., & Adashi, E. Y. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301467 · Cited by 310 · see citing works
Trends in Multiple Births Conceived Using Assisted Reproductive Technology, United States, 1997–2000
Reynolds, M. A., Schieve, L. A., Martin, J. A., Jeng, G. T., & Macaluso, M. (2003) · PEDIATRICS · doi:10.1542/peds.111.s1.1159 · Cited by 309 · see citing works
Socioeconomic and racial disparities among infertility patients seeking care
Jain, T. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.07.1338 · Cited by 304 · see citing works
Guidance on the limits to the number of embryos to transfer: a committee opinion
Penzias, A. S., Bendikson, K. A., Butts, S., Coutifaris, C., Fossum, G., Falcone, T., Gitlin, S., Gracia, C. R., Hansen, K., Barbera, A. L., et al. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.02.107 · Cited by 235 · see citing works
Racial and ethnic disparities in assisted reproductive technology outcomes in the United States
Fujimoto, V. Y., Luke, B., Brown, M. B., Jain, T., Armstrong, A. Y., Grainger, D. A., & Hornstein, M. D. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.10.061 · Cited by 208 · see citing works
Feinberg, E. C., Larsen, F. W., Catherino, W. H., Zhang, J., & Armstrong, A. Y. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.028 · Cited by 183 · see citing works
Assisted Reproductive Technology Surveillance — United States, 2016
Sunderam, S., Kissin, D. M., Zhang, Y., Folger, S. G., Boulet, S. L., Warner, L., Callaghan, W. M., & Barfield, W. D. (2019) · MMWR Surveillance Summaries · doi:10.15585/mmwr.ss6804a1 · Cited by 182 · see citing works
Disparity in assisted reproductive technologies outcomes in black women compared with white women
Seifer, D. B., Frazier, L. M., & Grainger, D. A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.08.024 · Cited by 145 · see citing works
Race-Ethnicity and Medical Services for Infertility
Greil, A. L., McQuillan, J., Shreffler, K. M., Johnson, K. M., & Slauson‐Blevins, K. S. (2011) · Journal of Health and Social Behavior · doi:10.1177/0022146511418236 · Cited by 142 · see citing works
Smith, J. F., Eisenberg, M. L., Glidden, D. V., Millstein, S. G., Cedars, M. I., Walsh, T. J., Showstack, J. A., Pasch, L. A., Adler, N. E., & Katz, P. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.04.054 · Cited by 141 · see citing works
(2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.07.1139 · Cited by 124 · see citing works
Infertility evaluation and treatment among women in the United States
Kessler, L. M., Craig, B. M., Plosker, S. M., Reed, D. R., & Quinn, G. P. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.040 · Cited by 115 · see citing works
Influence of race and ethnicity on in vitro fertilization outcomes: systematic review
Humphries, L. A., Chang, O. H., Humm, K. C., Sakkas, D., & Hacker, M. R. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.09.002 · Cited by 114 · see citing works
Wellons, M., Fujimoto, V. Y., Baker, V. L., Barrington, D. S., Broomfield, D., Catherino, W. H., Richard-Davis, G., Ryan, M., Thornton, K. L., & Armstrong, A. Y. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.05.012 · Cited by 105 · see citing works
Racial disparities in in vitro fertilization outcomes
McQueen, D. B., Schufreider, A., Lee, S. M., Feinberg, E. C., & Uhler, M. L. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.05.012 · Cited by 100 · see citing works
Chambers, G. M., Hoang, V. P., & Illingworth, P. J. (2013) · Human Reproduction · doi:10.1093/humrep/det302 · Cited by 94 · see citing works
Guidelines on number of embryos transferred
(2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.07.1473 · Cited by 75 · see citing works
Eisenberg, M. L., Smith, J. F., Millstein, S. G., Nachtigall, R. D., Adler, N. E., Pasch, L. A., & Katz, P. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.03.068 · Cited by 64 · see citing works
Stephen, E. H., Chandra, A., & King, R. B. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.10.007 · Cited by 57 · see citing works
Access to and use of infertility services in the United States: framing the challenges
Adashi, E. Y., & Dean, L. A. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.01.017 · Cited by 57 · see citing works
Who receives a medical evaluation for infertility in the United States?
Farland, L. V., Collier, A.-R. Y., Correia, K. F. B., Grodstein, F., Chavarro, J. E., Rich-Edwards, J. W., & Missmer, S. A. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.12.132 · Cited by 54 · see citing works
Fertility Treatments in the United States
Kissin, D. M., Boulet, S. L., & Jamieson, D. J. (2016) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000001419 · Cited by 39 · see citing works
Thoma, M. E., Boulet, S. L., Martin, J. A., et al. (2014) · PubMed · Cited by 35 · see citing works
Janitz, A. E., Peck, J. D., & Craig, L. B. (2018) · Maternal and Child Health Journal · doi:10.1007/s10995-018-2586-y · Cited by 33 · see citing works
Declines in Triplet and Higher-order Multiple Births in the United States, 1998-2014.
Martin, J. A., Osterman, M. J. K., & Thoma, M. E. (2016) · PubMed · Cited by 20 · see citing works
Moaddab, A., Bateni, Z. H., Dildy, G. A., et al. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.06.041 · Cited by 11 · see citing works
Ethnic Differences in Fertility and Assisted Reproduction
Sharara, F. I. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7548-4 · Cited by 11 · see citing works
Weedin, E. A., Janitz, A. E., Peck, J. D., et al. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.02.086 · Cited by 4 · see citing works
The Impact of Sociocultural and Economic Factors in Seeking Fertility Services
Dayal, M. B. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7548-4_3 · Cited by 2 · see citing works
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(2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.02.019 · Cited by 125 · see citing works
Age-related disparities in national maternal mortality trends: A population-based study
Huang, R. S., Spence, A. R., & Abenhaim, H. A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316578 · Cited by 9 · see citing works
- Authors
- Tierney, K., & Cai, Y.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Tierney, Katherine
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 112
- Issue
- 6
- Pages
- 1136-1143.e4
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC6986780
- OpenAlex
- W2996748246
- Cited by
- 53
- References
- 31
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 13 · 2023: 8 · 2022: 4 · 2021: 6 · 2020: 1
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Science Foundation
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- assisted reproduction, sociodemographic disparities, racial disparities, Hispanic women, Black women, Asian women, educational attainment, marital status, age differences, fertility trends, birth rate, total fertility rate, United States fertility, American Community Survey, birth certificate data, period effects
- MeSH terms
- Adolescent, Adult, Age Factors, Educational Status, Female, Humans, Infertility, Middle Aged, Pregnancy, Socioeconomic Factors, Time Factors, United States, Treatment Outcome, Marital Status, Reproductive Techniques, Assisted, Racial Groups, Live Birth, Healthcare Disparities, Young Adult, Social Determinants of Health
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