Cited by 246Natural Products and Biological ResearchNatural Antidiabetic Agents StudiesPhytochemicals and Antioxidant Activities

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Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies

Mollace, Vincenzo, Sacco, Iolanda, Janda, Elzbieta, Malara, Claudio, Ventrice, Domenica, Colica, Carmen, Visalli, Valeria, Muscoli, Saverio, Ragusa, Salvatore, Muscoli, Carolina, Rotiroti, Domenicantonio, Romeo, Franco·2011·Fitoterapia

DOI 10.1016/j.fitote.2010.10.014

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Abstract

Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders.

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Authors: Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., & Romeo, F.
Affiliations: Magna Graecia University (IT)
Agenzia Regionale per la Protezione dell'Ambiente della Calabria (IT)
University of Rome Tor Vergata (IT)
Corresponding author: Mollace, Vincenzo
ORCID: Mollace, Vincenzo
Muscoli, Saverio
Ragusa, Salvatore
Muscoli, Carolina
Venue: Fitoterapia
Publisher: Elsevier BV
Published: 2011-04
Volume: 82
Issue: 3
Pages: 309-316
ISSN: 0367-326X (ISSN-L)
DOI: 10.1016/j.fitote.2010.10.014
OpenAlex: W2073068954
Cited by: 246
References: 29
Citations by year: 2026: 16 · 2025: 9 · 2024: 23 · 2023: 25 · 2022: 19 · 2021: 15 · 2020: 18 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 12 · 2013: 8 · 2012: 6
FWCI: 5.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Fitoterapia (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: Citrus aurantium, hypolipidemic activity, hypoglycemic activity, hyperlipidemia, hyperglycemia, LDL cholesterol, HDL cholesterol, triglycerides, HMG-CoA reductase inhibition, herbal medicine, diet-induced hyperlipidemia
MeSH terms: Adult, Aged, Animals, Hypolipidemic Agents, Blood Glucose, Citrus, Double-Blind Method, Female, Humans, Hydroxymethylglutaryl CoA Reductases, Hyperglycemia, Hyperlipidemias, Hypoglycemic Agents, Lipids, Male, Phytotherapy, Middle Aged, Plant Extracts, Vasodilation, Rats, Wistar, Rats

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Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies

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