Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats
Abstract
In this study, we investigated the neuroprotective effects of madecassoside, isolated from the Chinese medicinal herb Centella asiatica, in the rat model of early phase of parkinsonism. During intragastric administrations of madecassoside for 7 days, the rats were injected with MPTP on the 7th day. And for the following 14 days, madecassoside were also administered. On the 14th day, the behavioral tests were assessed after 1h of administration. And then, the rats were sacrificed, substantia nigra and striatum were dissected. The content of DA, MDA, GSH, and Bcl-2/Bax gene expression levels and BDNF protein level was determined. Treatment with madecassoside was found to improve locomotor dysfunction and to protect dopaminergic neuron by antagonizing MPTP induced neurotoxicity. Madecassoside significantly attenuated the MPTP-induced reduction of dopamine in the striatum. The MDA contents were significantly decreased while the GSH levels, Bcl-2/Bax ratio and protein expression of BDNF were significantly increased in madecassoside treated groups. These results indicated that madecassoside was effective in recovering MPTP-induced early signs of parkinsonism via its neuroprotective effects including reversing the depletion of DA, antioxidant activity, increasing ratio of Bcl-2/Bax, increasing protein expression of BDNF.
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Madecassoside and asiaticoside are incorporated into the treatment of various neurodegenerative disorders like Alzheimer's and Parkinson's diseases.
“and are incorporated into the treatment of various neurodegenerative disorders like Alzheimer's and Parkinson's diseases. 33 , 34”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [34]
Madecassoside prevents early signs of Parkinsonism in MPTP-treated rats by reversing dopamine depletion, upregulating antioxidant activity and increasing the Bcl-2/Bax ratio.
“Madecassoside also exhibits similar properties, as seen in another study where the compound prevented early signs of Parkinsonism in MPTP‐treated rats by reversing the depletion of dopamine, upregulating antioxidant activity and increasing the Bcl‐2/Bax ratio. 34”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [34]
Cites
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Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
Wong, J. H., Barron, A. M., & Abdullah, J. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.687935 · Cited by 79 · see citing works
Tan, S. C., Bhattamisra, S. K., Chellappan, D. K., & Candasamy, M. (2021) · Applied Sciences · doi:10.3390/app11188475 · Cited by 72 · see citing works
Abduljawad, A. A., Elawad, M. A., Elkhalifa, M. E. M., Ahmed, A., Hamdoon, A. A. E., Salim, L. H. M., Ashraf, M., Ayaz, M., Hassan, S. S. U., & Bungau, S. (2022) · Molecules · doi:10.3390/molecules27206804 · Cited by 63 · see citing works
“Hence it attenuates the MPTP-elevated levels of iron, reduces the expression of DMT1 and increases the expression of FP1 in the SN [102].”
Background
- Authors
- Xu, C.-L., Qu, R., Zhang, J., Li, L.-F., & Ma, S.-P.
- Affiliations
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- ORCID
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 90
- Pages
- 112-118
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W1973689750
- Cited by
- 84
- References
- 1
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 13 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 6
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jiangsu Province Program (CXZZ11_0796)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- madecassoside, Centella asiatica, Parkinson's disease, MPTP-induced neurotoxicity, neuroprotection, dopaminergic neurons, substantia nigra, striatum, dopamine depletion, oxidative stress, antioxidant activity, Bcl-2/Bax ratio, brain-derived neurotrophic factor, locomotor dysfunction, Chinese herbal medicine
- MeSH terms
- Animals, Antioxidants, Brain, Corpus Striatum, Dopamine, Glutathione, Locomotion, Male, Malondialdehyde, Phytotherapy, Plant Extracts, Substantia Nigra, Triterpenes, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Rats, Wistar, Neuroprotective Agents, Brain-Derived Neurotrophic Factor, Proto-Oncogene Proteins c-bcl-2, MPTP Poisoning, Centella, Rats, Dopaminergic Neurons
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