Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

A guide to immunometabolism for immunologists

O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.70 · Cited by 3,315 · see citing works

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.064 · Cited by 2,291 · see citing works

Mitochondrial membrane potential

Zorova, L. D., Popkov, V. A., Plotnikov, E. Y., Silachev, D. N., Pevzner, I. B., Jankauskas, S. S., Babenko, V. A., Zorov, S. D., Balakireva, A. V., Juhaszova, M., et al. (2017) · Analytical Biochemistry · doi:10.1016/j.ab.2017.07.009 · Cited by 2,015 · see citing works

NRF2, a Transcription Factor for Stress Response and Beyond

He, F., Ru, X., & Wen, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134777 · Cited by 1,820 · see citing works

Mitochondria as sensors and regulators of calcium signalling

Rizzuto, R., De Stefani, D., Raffaello, A., & Mammucari, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3412 · Cited by 1,781 · see citing works

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Lampropoulou, V., Sergushichev, A., Bambousková, M., Nair, S., Vincent, E. E., Loginicheva, E., Cervantes‐Barragán, L., Ma, X., Huang, S. C., Griss, T., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.004 · Cited by 1,547 · see citing works

The mitochondrial basis of aging

Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441 · see citing works

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044 · cited 1× · see citing works

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

Rodríguez-Prados, J.-C., Través, P. G., Cuenca, J., Rico, D., Aragonés, J., Martín-Sanz, P., Cascante, M., & Boscá, L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901698 · Cited by 1,022 · see citing works

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Cunnane, S. C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z. B., Beal, M. F., Bergersen, L. H., Brinton, R. D., de la Monte, S., et al. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0072-x · Cited by 1,003 · see citing works

The emerging role of Nrf2 in mitochondrial function

Dinkova-Kostova, A. T., & Abramov, A. Y. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.036 · Cited by 983 · see citing works

Metabolic Reprograming in Macrophage Polarization

Galván-Peña, S., & O’Neill, L. A. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00420 · Cited by 944 · see citing works

Mitochondria as a therapeutic target for common pathologies

Murphy, M. P., & Hartley, R. C. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.174 · Cited by 832 · see citing works

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

Mańczak, M., Calkins, M. J., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr139 · Cited by 830 · see citing works

Mitochondrial Dysfunction in Neurodegenerative Diseases

Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806 · see citing works

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

Moreira, P. I., Carvalho, C., Zhu, X., Smith, M. A., & Perry, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.006 · Cited by 734 · see citing works

Pharmacological review on Centella asiatica: A potential herbal cure-all

Gohil, K., Patel, J. A., & Gajjar, A. (2010) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.78519 · Cited by 666 · see citing works

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

Gureev, A. P., Shaforostova, E. A., & Popov, V. N. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00435 · Cited by 652 · see citing works

Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslatica

Brinkhaus, B., Lindner, M., Schuppan, D., & Hahn, E. G. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80065-3 · Cited by 525 · see citing works

Mitochondrial pharmacology

Smith, R. A. J., Hartley, R. C., Cochemé, H. M., & Murphy, M. P. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.010 · Cited by 501 · see citing works

Reprogramming mitochondrial metabolism in macrophages as an anti‐inflammatory signal

Mills, E. L., & O'Neill, L. A. J. (2015) · European Journal of Immunology · doi:10.1002/eji.201445427 · Cited by 454 · see citing works

Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria

John, A., & Reddy, P. H. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101208 · Cited by 359 · see citing works

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target

Camara, A. K. S., Zhou, Y., Wen, P., Tajkhorshid, E., & Kwok, W.-M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00460 · Cited by 357 · see citing works

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

González, H., Elgueta, D., Montoya, A., & Pacheco, R. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.07.012 · Cited by 352 · see citing works

Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies

Elfawy, H. A., & Das, B. B. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.12.029 · Cited by 343 · see citing works

Centella asiatica: Phytochemistry and mechanisms of neuroprotection and cognitive enhancement

Gray, N. E., Alcazar Magana, A., Lak, P., Wright, K. M., Quinn, J., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-017-9528-y · Cited by 299 · see citing works

NRF2 as a Therapeutic Target in Neurodegenerative Diseases

Brandes, M. S., & Gray, N. E. (2020) · ASN Neuro · doi:10.1177/1759091419899782 · Cited by 297 · see citing works

Mitochondrial Quality Control as a Therapeutic Target

Suliman, H. B., & Piantadosi, C. A. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.011502 · Cited by 265 · see citing works

Effect of <i>Centella asiatica</i> on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats

Veerendra Kumar, M., & Gupta, Y. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03842.x · Cited by 249 · see citing works

<i>Centella asiatica</i>(L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential

Orhan, I. E. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/946259 · Cited by 238 · see citing works

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

Bahn, G., Park, J.-S., Yun, U. J., Lee, Y. J., Choi, Y., Park, J. S., Baek, S. H., Choi, B. Y., Cho, Y. S., Kim, H. K., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1819541116 · Cited by 210 · see citing works

Bioavailability, Distribution, and Antioxidative Effects of Selected Triterpenes in Mice

Yin, M., Lin, M., Mong, M., & Lin, C.-Y. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302529x · Cited by 179 · see citing works

High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions

Elibol, B., & Kilic, U. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00614 · Cited by 171 · see citing works

Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

Xu, M.-F., Xiong, Y.-Y., Liu, J.-K., Qian, J.-J., Zhu, L., & Gao, J. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.3 · Cited by 156 · see citing works

Asiatic acid, a pentacyclic triterpene from <i>Centella asiatica</i>, is neuroprotective in a mouse model of focal cerebral ischemia

Krishnamurthy, R. G., Senut, M., Zemke, D., Min, J., Frenkel, M. B., Greenberg, E. J., Yu, S., Ahn, N., Goudreau, J., Kassab, M., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22071 · Cited by 155 · see citing works

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Perez‐Nievas, B. G., Bertrand, H. C., Martinez, P., Callard, R., Snoeren, I., Cochemé, H. M., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006593 · Cited by 146 · see citing works

GAPDH Binding to TNF-α mRNA Contributes to Posttranscriptional Repression in Monocytes: A Novel Mechanism of Communication between Inflammation and Metabolism

Millet, P., Vachharajani, V., McPhail, L. C., Yoza, B. K., & McCall, C. E. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501345 · Cited by 141 · see citing works

Centella asiatica Attenuates D‐Galactose‐Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice

Kumar, A., Prakash, A. K., & Dogra, S. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/347569 · Cited by 135 · see citing works

Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice

Gray, N. E., Harris, C. J., Quinn, J. F., & Soumyanath, A. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.01.013 · Cited by 123 · see citing works

Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease

Fairley, L. H., Wong, J. H., & Barron, A. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.624538 · Cited by 120 · see citing works

Centella asiaticaExtract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action

Soumyanath, A., Zhong, Y.-P., Henson, E., Wadsworth, T. L., Bishop, J., Gold, B. G., & Quinn, J. F. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/381974 · Cited by 112 · see citing works

Mitochondria in the pathophysiology of Alzheimer s and Parkinson s diseases

Onyango, I. G. (2017) · Frontiers in Bioscience · doi:10.2741/4521 · Cited by 107 · see citing works

Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing

Sabaragamuwa, R., Perera, C. O., & Fedrizzi, B. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.07.024 · Cited by 103 · see citing works

Seasonal variation of triterpenes and phenolic compounds in australian Centella asiatica (L.) Urb

Alqahtani, A. S., Tongkao‐on, W., Li, K. M., Razmovski‐Naumovski, V., Chan, K., & Li, G. Q. (2015) · Phytochemical Analysis · doi:10.1002/pca.2578 · Cited by 101 · see citing works

Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model

Park, J., Choi, J., Son, D., Park, E., Song, M., Hellström, M., & Hong, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040738 · Cited by 97 · see citing works

Asiaticoside attenuates memory impairment induced by transient cerebral ischemia–reperfusion in mice through anti-inflammatory mechanism

Chen, S., Yin, Z.-J., Jiang, C., Ma, Z., Fu, Q., Qu, R., & Ma, S. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.004 · Cited by 96 · see citing works

Neuroinflammatory Responses and Parkinson’ Disease: Pathogenic Mechanisms and Therapeutic Targets

Yang, L., Mao, K., Yu, H., & Chen, J. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09926-7 · Cited by 90 · see citing works

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86 · cited 3× · see citing works

Protective Effects of Asiatic Acid on Rotenone- or H2O2-Induced Injury in SH-SY5Y Cells

Xiong, Y., Ding, H., Minfang, X., & Gao, J. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9844-0 · Cited by 85 · see citing works

Anti-inflammatory effect of Centella asiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis

Ho, P. J., Sung, J. J., Cheon, K. K., & Hong, J. T. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.04.013 · Cited by 85 · see citing works

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice

Gray, N. E., Zweig, J. A., Caruso, M., Zhu, J. Y., Wright, K. M., Quinn, J. F., & Soumyanath, A. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.09.002 · Cited by 85 · see citing works

Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats

Xu, C.-L., Qu, R., Zhang, J., Li, L.-F., & Ma, S.-P. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.07.009 · Cited by 84 · see citing works

Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells

Nataraj, J., Manivasagam, T., Thenmozhi, A. J., & Essa, M. M. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1135559 · Cited by 81 · see citing works

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease

Bento‐Pereira, C., & Dinkova‐Kostova, A. T. (2020) · Medicinal Research Reviews · doi:10.1002/med.21714 · Cited by 78 · see citing works

<i>Centella asiatica</i> increases hippocampal synaptic density and improves memory and executive function in aged mice

Gray, N. E., Zweig, J. A., Caruso, M., Martin, M. D., Zhu, J. Y., Quinn, J. F., & Soumyanath, A. (2018) · Brain and Behavior · doi:10.1002/brb3.1024 · Cited by 76 · see citing works

Chemical structures, production and enzymatic transformations of sapogenins and saponins from Centella asiatica (L.) Urban

Azerad, R. G. (2016) · Fitoterapia · doi:10.1016/j.fitote.2016.07.011 · Cited by 75 · see citing works

Asiatic Acid Prevents the Deleterious Effects of Valproic Acid on Cognition and Hippocampal Cell Proliferation and Survival

Welbat, J. U., Sirichoat, A., Chaijaroonkhanarak, W., Prachaney, P., Pannangrong, W., Pakdeechote, P., Sripanidkulchai, B., & Wigmore, P. M. (2016) · Nutrients · doi:10.3390/nu8050303 · Cited by 73 · see citing works

Comparison of three different extracts of Centella asiatica for anti-amnesic, antioxidant and anticholinergic activities: In vitro and in vivo study

Arora, R., Kumar, R., Agarwal, A., Reeta, K. H., & Gupta, Y. K. (2018) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2018.05.156 · Cited by 73 · see citing works

Asiaticoside Attenuates Cell Growth Inhibition and Apoptosis Induced by Aβ1-42 via Inhibiting the TLR4/NF-κB Signaling Pathway in Human Brain Microvascular Endothelial Cells

Song, D., Jiang, X., Liu, Y., Sun, Y., Cao, S., & Zhang, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00028 · Cited by 72 · see citing works

Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats

Luo, Y., Yang, Y., Liu, J., Li, W.-H., Yang, J., Sui, X. Y., Yuan, X., Nie, Z., Liu, Y., Chen, D., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.008 · Cited by 70 · see citing works

Centella asiatica extract protects against amyloid β1–40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system

Chen, C.-L., Tsai, W.-H., Chen, C.-J., & Pan, T.-M. (2016) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2015.07.002 · Cited by 69 · see citing works

Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus

Sirichoat, A., Chaijaroonkhanarak, W., Prachaney, P., Pannangrong, W., Leksomboon, R., Chaichun, A., Wigmore, P. M., & Welbat, J. U. (2015) · Nutrients · doi:10.3390/nu7105401 · Cited by 69 · see citing works

Elite genotypes/chemotypes, with high contents of madecassoside and asiaticoside, from sixty accessions of Centella asiatica of south India and the Andaman Islands: For cultivation and utility in cosmetic and herbal drug applications

Thomas, M. T., Kurup, R., Johnson, A. J., Chandrika, S. P., Mathew, P. J., Dan, M., & Baby, S. (2010) · Industrial Crops and Products · doi:10.1016/j.indcrop.2010.07.003 · Cited by 68 · see citing works

Protective effects of Centella asiatica leaf extract on dimethylnitrosamine-induced liver injury in rats

Choi, M., Zheng, H., Kim, J. M., Lee, K. W., Park, Y. H., & Lee, D. H. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5809 · Cited by 66 · see citing works

Asiatic Acid Protects Dopaminergic Neurons from Neuroinflammation by Suppressing Mitochondrial ROS Production

Chen, D., Zhang, X., Sun, J., Cong, Q., Chen, W.-X., Ahsan, H. M., Gao, J., & Qian, J.-J. (2019) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.188 · Cited by 66 · see citing works

Neuroprotective effect of a standardized extract of Centella asiatica ECa233 in rotenone-induced parkinsonism rats

Teerapattarakan, N., Benya-aphikul, H., Tansawat, R., Wanakhachornkrai, O., Tantisira, M. H., & Rodsiri, R. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.04.028 · Cited by 65 · see citing works

Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer’s disease

Yoo, S., Park, J., Kim, S., & Jung, Y. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.1.274 · Cited by 65 · see citing works

Nrf2/ARE Pathway as a Therapeutic Target for the Treatment of Parkinson Diseases

Gureev, A. P., & Popov, V. N. (2019) · Neurochemical Research · doi:10.1007/s11064-018-02711-2 · Cited by 64 · see citing works

Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex

Sbrini, G., Brivio, P., Fumagalli, M., Giavarini, F., Caruso, D., Racagni, G., Dell’Agli, M., Sangiovanni, E., & Calabrese, F. (2020) · Nutrients · doi:10.3390/nu12020355 · Cited by 63 · see citing works

Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats

Anukunwithaya, T., Tantisira, M. H., Tantisira, B., & Khemawoot, P. (2016) · Planta Medica · doi:10.1055/s-0042-122344 · Cited by 60 · see citing works

<i>Centella asiatica</i> Attenuates Mitochondrial Dysfunction and Oxidative Stress in A<i>β</i>‐Exposed Hippocampal Neurons

Gray, N. E., Zweig, J. A., Matthews, D. G., Caruso, M., Quinn, J. F., & Soumyanath, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7023091 · Cited by 60 · see citing works

Discrimination of Three Pegaga (Centella) Varieties and Determination of Growth-Lighting Effects on Metabolites Content Based on the Chemometry of 1H Nuclear Magnetic Resonance Spectroscopy

Maulidiani, M., Khatib, A., Shaari, K., Abas, F., Shitan, M., Kneer, R., Neto, V., & Lajis, N. H. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200270y · Cited by 59 · see citing works

Centella asiatica in food and beverage applications and its potential antioxidant and neuroprotective effect

Hashim, P. (2011) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · Cited by 59 · see citing works

Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of the Sirt1/NF-κB signaling pathway

Qian, Y., Xin, Z., Lv, Y., Wang, Z., Zuo, L., Huang, X., Li, Y., & Xin, H.-B. (2017) · Food & Function · doi:10.1039/c7fo01442b · Cited by 55 · see citing works

Notes on the occurrence and significance of triterpenoids (asiaticoside and related compounds) and caffeoylquinic acids in Centella species

Long, H. S., Stander, M. A., & Wyk, B.-E. V. (2012) · South African Journal of Botany · doi:10.1016/j.sajb.2012.07.017 · Cited by 54 · see citing works

Madecassic Acid protects against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ROS-mediated endoplasmic reticulum stress

Yang, B., Xu, Y., Hu, Y., Luo, Y., Lü, X., Tsui, C., Lü, L., & Liang, X. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.015 · Cited by 50 · see citing works

Ethnobotany, Phytochemistry and Pharmacological Features of Centella asiatica: A Comprehensive Review

Abedi, F., Ramezani, M., Dehghan, R., Amiri, M. S., Moghadam, A. T., Shakour, N., Elyasi, S., Sahebkar, A., & Emami, S. A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-64872-5_25 · Cited by 48 · see citing works

Effect ofCentella asiaticaon Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models

Zhao, Y., Shu, P., Zhang, Y., Lin, L., Zhou, H., Xu, Z., Suo, D., Xie, A., & Jin, X. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/154295 · Cited by 46 · see citing works

Blood-Brain Barrier Permeability of Asiaticoside, Madecassoside and Asiatic Acid in Porcine Brain Endothelial Cell Model

Hanapi, N. A., Arshad, A. S. M., Abdullah, J. M., Muhammad, T. S. T., & Yusof, S. R. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.09.015 · Cited by 45 · see citing works

Microglia immunometabolism: From metabolic disorders to single cell metabolism

Paolicelli, R. C., & Angiari, S. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.03.012 · Cited by 44 · see citing works

Antioxidant and α-Glucosidase Inhibitory Compounds of Centella Asiatica

Dewi, R. T., & Maryani, F. (2015) · Procedia Chemistry · doi:10.1016/j.proche.2015.12.130 · Cited by 42 · see citing works

Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of α-Synuclein Into Mitochondria

Ding, H., Xiong, Y., Sun, J., Chen, C., Gao, J., & Xu, H. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00431 · Cited by 42 · see citing works

A new method for preparing pentacyclic triterpene rich Centella asiatica extracts

Puttarak, P., & Panichayupakaranant, P. (2012) · Natural Product Research · doi:10.1080/14786419.2012.686912 · Cited by 40 · see citing works

Mitochondrial fragmentation and network architecture in degenerative diseases

Shah, S. I., Paine, J. G., Perez, C., & Ullah, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223014 · Cited by 39 · see citing works

A combination of simultaneous quantification of four triterpenes and fingerprint analysis using HPLC for rapid identification of Centella asiatica from its related plants and classification based on cultivation ages

Rafi, M., Handayani, F., Darusman, L. K., Rohaeti, E., Wahyu, Y., Sulistiyani, Honda, K., & Putri, S. P. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.05.062 · Cited by 38 · see citing works

Low temperature and water dehydration increase the levels of asiaticoside and madecassoside in Centella asiatica (L.) Urban

Plengmuankhae, W., & Tantitadapitak, C. (2015) · South African Journal of Botany · doi:10.1016/j.sajb.2015.01.013 · Cited by 37 · see citing works

Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats

Giribabu, N., Srinivasarao, N., Rekha, S. S., Muniandy, S., & Salleh, N. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/592062 · Cited by 36 · see citing works

Asiatic Acid Prevents Cognitive Deficits by Inhibiting Calpain Activation and Preserving Synaptic and Mitochondrial Function in Rats with Kainic Acid-Induced Seizure

Lü, C.-W., Lin, T., Pan, T., Wang, P., Chiu, K., Lee, M.-Y., & Wang, S. (2021) · Biomedicines · doi:10.3390/biomedicines9030284 · Cited by 36 · see citing works

Asiaticoside ameliorates β-amyloid-induced learning and memory deficits in rats by inhibiting mitochondrial apoptosis and reducing inflammatory factors

Zhang, Z., Li, X., Li, D., Luo, M., Li, Y., Li, S., & Jiang, X. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.4004 · Cited by 35 · see citing works

Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging

Zweig, J. A., Brandes, M. S., Brumbach, B. H., Caruso, M. A., Wright, K. M., Quinn, J. F., Soumyanath, A., & Gray, N. E. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.11.019 · Cited by 35 · see citing works

Functional constituents (micronutrients and phytochemicals) and antioxidant activity of Centella asiatica (L.) Urban leaves

Singh, S. K., Singh, D. R., Banu, V. S., & Avinash, N. G. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.06.045 · Cited by 34 · see citing works

The novel phytocomponent asiaticoside-D isolated from Centella asiatica exhibits monoamine oxidase-B inhibiting potential in the rotenone degenerated cerebral ganglions of Lumbricus terrestris

Subaraja, M., & Vanisree, A. J. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152833 · Cited by 29 · see citing works

Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi’s Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics

Szalárdy, L., Zádori, D., Klivènyi, P., Toldi, J., & Vécsei, L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/498401 · Cited by 28 · see citing works

The Influence of Certain Taxonomic and Environmental Parameters on Biomass Production and Triterpenoid Content in the Leaves of Centella asiatica (L.) Urb. from Madagascar

Rahajanirina, V., RAOSETA, S. O. R., Roger, E., Razafindrazaka, H., Pirotais, S., Boucher, M., & Danthu, P. (2012) · Chemistry & Biodiversity · doi:10.1002/cbdv.201100073 · Cited by 28 · see citing works

LC-ESI-MS/MS Method for Simultaneous Determination of Triterpenoid Glycosides and Aglycones in Centella asiatica L.

Gajbhiye, N., Makasana, J., Saha, A., Patel, I., & Jat, R. S. (2016) · Chromatographia · doi:10.1007/s10337-016-3089-x · Cited by 28 · see citing works

Asiaticoside: Attenuation of rotenone induced oxidative burden in a rat model of hemiparkinsonism by maintaining the phosphoinositide-mediated synaptic integrity

Gopi, M., & Janardhanam, V. A. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.02.005 · Cited by 28 · see citing works

Differential expression of entorhinal cortex and hippocampal subfields α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors enhanced learning and memory of rats following administration of Centella asiatica

Wong, J. H., Muthuraju, S., Reza, F., Senik, M. H., Zhang, J., Yeo, N. A. B. M. Y., Chuang, H. G., Jaafar, H., Yusof, S. R., Mohamad, H., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.044 · Cited by 28 · see citing works

Effectiveness of traditional Malaysian vegetables (ulam) in modulating blood glucose levels.

Bachok, M. F., Yusof, B. N. M., Ismail, A., & Hamid, A. A. (2014) · PubMed · doi:10.6133/apjcn.2014.23.3.01 · Cited by 26 · see citing works

Hippocampal amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid GluA1 ( AMPA GluA1) receptor subunit involves in learning and memory improvement following treatment withCentella asiaticaextract in adolescent rats

Yeo, N. A. B. M. Y., Muthuraju, S., Wong, J. H., Mohammed, F. R., Senik, M. H., Zhang, J., Yusof, S. R., Jaafar, H., Adenan, M. L., Mohamad, H., et al. (2018) · Brain and Behavior · doi:10.1002/brb3.1093 · Cited by 26 · see citing works

Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats

Zheng, H., Choi, M., Kim, J. M., Hoi, K., Lee, K. W., Park, Y. H., Hong, S., & Lee, D. H. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2015.3464 · Cited by 25 · see citing works

Genetic variability and associations in the accessions of Manduk parni { Centella asiatica (L)}

Lal, R. K., Gupta, P., & Dubey, B. K. (2016) · Industrial Crops and Products · doi:10.1016/j.indcrop.2016.11.056 · Cited by 25 · see citing works

Current Updates on Centella asiatica: Phytochemistry, Pharmacology and Traditional Uses

Md, M. S. (2013) · Medicinal Plant Research · doi:10.5376/mpr.2013.03.0004 · Cited by 24 · see citing works

Behavioral and neurochemical consequences of perinatal exposure to lead in adult male Wistar rats: protective effect by Centella asiatica

Chintapanti, S., Reddy, K. P., & Reddy, P. S. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-1500-x · Cited by 22 · see citing works

Centella asiatica (L.) Urb.: ethnomedicinal uses and their scientific validations.

Jahan, R., Hossain, S., Seraj, S., Nasrin, D., Khatun, Z., Das, P. R., Islam, M. T., Ahmed, I., & Rahmatullah, M. (2012) · AMERICAN-EURASIAN JOURNAL OF SUSTAINABLE AGRICULTURE · Cited by 20 · see citing works

Study of ameliorating effects of ethanolic extract of Centella asiatica on learning and memory deficit in animal models.

Doknark, S., Mingmalairak, S., Vattanajun, A., Tantisira, B., & Tantisira, M. H. (2014) · PubMed · Cited by 19 · see citing works

Effects of <scp><i>Centella asiatica</i></scp> extract on antioxidant status and liver metabolome of rotenone‐treated rats using GC–MS

Intararuchikul, T., Teerapattarakan, N., Rodsiri, R., Tantisira, M., Wohlgemuth, G., Fiehn, O., & Tansawat, R. (2019) · Biomedical Chromatography · doi:10.1002/bmc.4395 · Cited by 19 · see citing works

Ethanol extracts of centella asiatica leaf improves memory performance in rats after chronic stress via reducing nitric oxide and increasing Brain-Derived Neurotrophic Factor (BDNF) Concentration

Sari, D. C. R., Aswin, S., Susilowati, R., Ar-Rochmah, M., Prakosa, D., Romi, M., Tranggono, U., & Arfian, N. (2014) · GSTF Journal of Psychology · doi:10.7603/s40790-014-0009-0 · Cited by 18 · see citing works

Antimicrobial Activity of Centella Asiatica on Aspergillus Niger and Bacillus Subtilis

Idris, F. N., & Nadzir, M. M. (2017) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.3303/cet1756231 · Cited by 18 · see citing works

Treatment with Centalla asiatica (Linn) fresh leaf extract enhances learning ability and memory retention power in rats

Rao, M. K., Rao, M. S. R., & Rao, G. S. (2007) · Neurosciences · doi:10.17712/1658-3183.1512 · Cited by 17 · see citing works

Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233

Wanasuntronwong, A., Wanakhachornkrai, O., Phongphanphanee, P., Isa, T., Tantisira, B., & Tantisira, M. H. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/3853147 · Cited by 17 · see citing works

Multiple Oral Dosing Pharmacokinetics of Standardized Extract of Centella asiatica ECa 233 and Its Inductive Effect on Efflux Transporters in Rats

Anukunwithaya, T., Tantisira, M. H., Shimada, T., Sai, Y., & Khemawoot, P. (2017) · Planta Medica International Open · doi:10.1055/s-0043-114669 · Cited by 16 · see citing works

Cytoprotective effect of Centella asiatica is mediated through the modulation of mitochondrial voltage-dependent anion channel (VDAC) and scavenging of free radicals

Tewari, D., Mukhopadhyay, M., Nekkanti, M. S., Vallabhaneni, S., Sahu, G., Jetti, S. K., Preethidan, D. S., & Bera, A. K. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.11.047 · Cited by 14 · see citing works

Studies on chemotypic variation inCentella asiatica(L.) Urban from Nilgiri range of India

Srivastava, S. K., Verma, S., Gupta, A., Rajan, S., & Rawat, A. K. S. (2014) · Journal of Planar Chromatography – Modern TLC · doi:10.1556/jpc.27.2014.6.9 · Cited by 11 · see citing works

THE DOSE VARIATIONS EFFECT OF Centella asiatica ETHANOL EXTRACT ON ESCAPE LATENCY’S DISTANCE MORRIS WATER MAZE AFTER CHRONIC ELECTRICAL STRESS

Yolanda, D. A., Sari, D. C. R., Rochmah, M. A., & Suharmi, S. (2015) · KnE Life Sciences · doi:10.18502/kls.v2i1.134 · Cited by 6 · see citing works

THE EFFECTS OF ETHANOL EXTRACTS OF Centella asiatica LEAF ON SERIAL SERUM BRAIN DERIVED NEUROTROPHIN FACTOR (BDNF) CONCENTRATION OF RATS (SPRAGUE DAWLEY) FOLLOWING CHRONIC STRESS

Sari, D. C. R., & Rochmah, M. A. (2015) · KnE Life Sciences · doi:10.18502/kls.v2i1.136 · Cited by 6 · see citing works

Acute application of Centella asiatica extract enhanced AMPAR-mediated postsynaptic currents in rat entorhinal cortex

Wong, J. H., Reza, F., Muthuraju, S., Chuang, H. G., Zhang, J., Senik, M. H., Yusof, S. R., Mohamad, H., Muhammad, T. S. T., Ismail, N. H., et al. (2020) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2020.02.50 · Cited by 5 · see citing works

Improvement in Cognitive Parameters Among Offsprings Born to Alcohol Fed Female Wistar Rats Following Long Term Treatment with Centella Asiatica.

Mitha, K. V., Yadav, S. J., & Ganaraja, B. (2016) · PubMed · Cited by 4 · see citing works

Centellaasiatica Morphotypes Differ Genetically as well as Macronutrients Content, Total Phenolic Content and Chemical Fingerprints of Leaves

Chandrasekara, C. H. W. M. R. B., Sumanarathne, R. A. P. I., & Bandaranayake, P. C. G. (2020) · Journal of Agricultural Sciences – Sri Lanka · doi:10.4038/jas.v15i1.8673 · Cited by 3 · see citing works

Effect of Centella asiatica Ethanol Extract in Spatial Working Memory on Adult Male Rats

Suri, A. A., Handayani, A., Ferhad, A., Farida, S. N., & Redjeki, S. (2018) · Advanced Science Letters · doi:10.1166/asl.2018.12641 · Cited by 2 · see citing works

Anti-hypertensive and cerebral blood flow improving actions of Centella asiatica (L.) Urban leaves juice in deoxycorticosterone acetate-salt hypertensive rats

Thirawarapan, S. S., Jariyapongsakul, A., Suvitayavat, W., Muangnongwa, S., & Sribusarakum, A. (2019) · Pharmaceutical Sciences Asia · doi:10.29090/psa.2019.03.018.0002 · Cited by 2 · see citing works

High-Altitude Medicinal Plants as Promising Source of Phytochemical Antioxidants to Combat Lifestyle-Associated Oxidative Stress-Induced Disorders

Ashraf, M. V., Khan, S., Misri, S., Gaira, K. S., Rawat, S., Rawat, B., Khan, M. A. H., Shah, A. A., Asgher, M., & Ahmad, S. (2024) · Pharmaceuticals · doi:10.3390/ph17080975 · Cited by 102 · see citing works

Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica

Hambali, A., Kumar, J., Hashim, N. F. M., Maniam, S., Mehat, M. Z., Cheema, M. S., Mustapha, M., Adenan, M. I., Stanslas, J., & Hamid, H. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.712317 · Cited by 62 · see citing works

Antioxidative role of Traditional Chinese Medicine in Parkinson's disease

Muhammad, F., Liu, Y., Zhou, Y., Yang, H., & Li, H. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114821 · Cited by 47 · see citing works

Elucidation of the Biosynthesis of Asiaticoside and Its Reconstitution in Yeast

Zhao, X., Wei, W., Li, S., Gao, S., Liu, S., Zeng, W., & Zhou, J. (2024) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.3c07046 · Cited by 28 · see citing works

Biosynthesis and bioactivities of triterpenoids from Centella asiatica: Challenges and opportunities

Zeng, W., Li, H., Liu, S., Luo, Z., Chen, J., & Zhou, J. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108541 · Cited by 27 · see citing works

Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review

Wiciński, M., Fajkiel-Madajczyk, A., Kurant, Z., Gajewska, S., Kurant, D., Kurant, M., & Sousak, M. (2024) · Cancers · doi:10.3390/cancers16071317 · Cited by 27 · see citing works

Advances and Challenges in Biomanufacturing of Glycosylation of Natural Products

Hu, S., Wang, B., Pei, L., Wang, J., Gan, Y., Jiang, L., Liu, B., Cheng, J., & Li, W. (2024) · Fermentation · doi:10.3390/fermentation10070349 · Cited by 24 · see citing works

Potential bioactive compounds and mechanisms of Fibraurea recisa Pierre for the treatment of Alzheimer’s disease analyzed by network pharmacology and molecular docking prediction

Wang, S., Ma, Y., Hu, Y., Huang, Y., Huang, Y., & Wu, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1052249 · Cited by 24 · see citing works

In Silico Analysis Reveals the Inhibitory Potential of Madecassic Acid against Entry Factors of SARS-CoV-2

Ganguly, A., Mandi, M., Dutta, A., & Rajak, P. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00916 · Cited by 22 · see citing works

Nutraceutical Strategies for Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases

Davì, F., Iaconis, A., Cordaro, M., Paola, R. D., & Fusco, R. (2025) · Foods · doi:10.3390/foods14132193 · Cited by 19 · see citing works

Role of Mandukparni (Centella asiatica Linn Urban) in neurological disorders: Evidence from ethnopharmacology and clinical studies to network enrichment analysis

Sharma, R., Banerjee, S., & Sharma, R. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105865 · Cited by 18 · see citing works

Neuroprotective prospectives of triterpenoids

Bankar, A. A., Nagulwar, V. P., Kotagale, N. R., & Inamdar, N. (2024) · Exploration of neuroscience · doi:10.37349/en.2024.00047 · Cited by 16 · see citing works

Could protein phosphatase 2A and glycogen synthase kinase-3 beta be targeted by natural compounds to ameliorate Alzheimer’s pathologies?

Manoharan, S. D., Hamid, H. A., Hashim, N. F. M., Cheema, M. S., Chiroma, S. M., Mustapha, M., & Mehat, M. Z. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148793 · Cited by 14 · see citing works

Does Gotu kola supplementation improve cognitive function, inflammation, and oxidative stress more than multicomponent exercise alone? – a randomized controlled study

Phoemsapthawee, J., Ammawat, W., Prasertsri, P., Sathalalai, P., & Leelayuwat, N. (2022) · Journal of Exercise Rehabilitation · doi:10.12965/jer.2244388.194 · Cited by 13 · see citing works

Asiaticoside attenuates oxygen–glucose deprivation/reoxygenation‐caused injury of cardiomyocytes by inhibiting autophagy

Yao, M., Wang, J., Zhang, J., Guo, Y., Ni, Z., Jia, X., & Feng, H. (2022) · Journal of Applied Toxicology · doi:10.1002/jat.4424 · Cited by 13 · see citing works

Research on the signaling pathways related to the intervention of traditional Chinese medicine in Parkinson's disease:A literature review

Jin, X., Dong, W., Chang, K., & Yan, Y. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117850 · Cited by 13 · see citing works

Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice

Varada, S., Chamberlin, S. R., Bui, L., Brandes, M. S., Gladen-Kolarsky, N., Harris, C., Hack, W. R., Neff, C. J., Brumbach, B. H., Soumyanath, A., et al. (2025) · Nutrients · doi:10.3390/nu17040729 · Cited by 13 · see citing works

Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal

Acero, N., Ortega, T., Villagrasa, V., Leon, G., Mingarro, D. M., Castillo, E., González‐Rosende, M. E., Borrás, S., Rı́os, J. L., Bosch‐Morell, F., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.7727 · Cited by 13 · see citing works

Phytochemicals in Parkinson’s Disease: a Pathway to Neuroprotection and Personalized Medicine

Das, S., Rajeswari, V. D., Venkatraman, G., & Ramanathan, G. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01607-z · Cited by 12 · see citing works

Centellosides: pharmaceutical applications and production enhancement strategies

Luthra, R., Satija, G., & Roy, A. (2021) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-021-02187-z · Cited by 12 · see citing works

Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson’s Disease Model by Alleviating Mitochondrial Dysfunction

Aleksandrova, Y. R., Chaprov, K., Podturkina, A. V., Ardashov, O. V., Yandulova, E. Y., Volcho, K. P., Salakhutdinov, N. F., & Неганова, М. Е. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065842 · Cited by 12 · see citing works

Rapid Separation of Asiatic Acid, Quercetin, and Kaempferol from Traditional Chinese Medicine Centella asiatica (L.) Urban Using HSCCC-Semi-Prep-HPLC and the Assessment of Their Potential as Fatty Acid Synthase Inhibitors

Xia, B., Li, Y., Liu, Y., Sun, W., Chen, J., Li, L., Pang, J., Liu, X., Chen, S., & Cheng, H. (2023) · International Journal of Analytical Chemistry · doi:10.1155/2023/7769368 · Cited by 12 · see citing works

Centella asiatica mitigates the detrimental effects of Bisphenol-A (BPA) on pancreatic islets

Banerjee, O., Singh, S., Paul, T., Maji, B. K., & Mukherjee, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-58545-2 · Cited by 11 · see citing works

Neuroprotective effects of Centella asiatica against LPS/amyloid beta-induced neurodegeneration through inhibition of neuroinflammation

Ansari, S., Maurya, V. K., Kumar, S., Tiwari, M. L., Abdel-Moneime, A. S., & Saxena, S. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.04.011 · Cited by 10 · see citing works

Biotechnological and endophytic-mediated production of centellosides in Centella asiatica

Mandal, S., Das, T., Nandy, S., Ghorai, M., Saha, S. C., Gopalakrishnan, A. V., Kumar, M., Radha, Ghosh, A., Mukerjee, N., et al. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12316-z · Cited by 10 · see citing works

Multiplex Bar-HRM for differentiating Centella asiatica (L.) Urb. from possible substituent species

Nukool, W., Kamol, P., Inthima, P., Nangngam, P., Chomdej, S., & Buddhachat, K. (2023) · Industrial Crops and Products · doi:10.1016/j.indcrop.2023.117567 · Cited by 10 · see citing works

Asiatic acid alleviates subarachnoid hemorrhage-induced brain injury in rats by inhibiting ferroptosis of neurons via targeting acyl-coenzyme a oxidase 1

Hu, Y., Gu, J., Jin, X., Wu, X., Li, H., Bai, L., Wu, J., & Li, X. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110208 · Cited by 9 · see citing works

Harnessing postharvest light emitting diode (LED) technology of Centella asiatica (L.) Urb. to improve centelloside content by up-regulating gene expressions in the triterpenoid pathway

Kamol, P., Nukool, W., Pumjaroen, S., Inthima, P., Kongbangkerd, A., Suphrom, N., & Buddhachat, K. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23639 · Cited by 9 · see citing works

Neuroprotective Action of Selected Natural Drugs Against Neurological Diseases and Mental Disorders: Potential Use Against Radiation Damage

Akhlada, Siddiqui, N., Anurag, Saifi, A., Kesharwani, A., Parihar, V. K., & Sharma, A. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04184-y · Cited by 7 · see citing works

Mass spectrometry and synchrotron‐FTIR microspectroscopy reveal the anti‐inflammatory activity of Bua Bok extracts

Paemanee, A., Rattanabunyong, S., Ketngamkum, Y., Siriwaseree, J., Pongpamorn, P., Romyanon, K., Tangphatsornruang, S., Kuaprasert, B., & Choowongkomon, K. (2022) · Phytochemical Analysis · doi:10.1002/pca.3161 · Cited by 7 · see citing works

In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide

Galla, R., Ferrari, S., Miletto, I., Mulè, S., & Uberti, F. (2025) · Foods · doi:10.3390/foods14152678 · Cited by 6 · see citing works

Sintesa Nanopartikel Senyawa Bioaktif Daun Pegagan (Centella asiatica) dan Uji Pengaruh Pemanasan dan Tekanan Terhadap Diameter dan Indeks Polidispersitasnya

Saragih, H. (2024) · JPSCR Journal of Pharmaceutical Science and Clinical Research · doi:10.20961/jpscr.v9i1.74982 · Cited by 5 · see citing works

Aromatic Plants as Potential Resources to Combat Osteoarthritis

Maring, M., Balaji, C., Komala, M., Nandi, S., Latha, S., & Raghavendran, H. R. B. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073267213231004094629 · Cited by 5 · see citing works

Centella asiatica as a potential neurotherapeutic adjunct in oxidative stress–targeted stem cell therapies

Fadzli, N. F. M., Bakri, S. S. M. A., & Nordin, N. (2025) · Current Opinion in Physiology · doi:10.1016/j.cophys.2025.100865 · Cited by 4 · see citing works

Effect of madecassic acid on retinal oxidative stress, inflammation and Growth Factors in streptozotocin-induced diabetic rats

Wang, X., Guo, L., Zhang, W., Song, Y., Almoallim, H. S. M., Aljawdah, H. M. A., & Quan, S. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150745 · Cited by 4 · see citing works

Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis

Kundu, P., Yasuhara, K., Brandes, M. S., Zweig, J. A., Neff, C. J., Holden, S. J., Kessler, K., Matsumoto, S. G., Offner, H., Waslo, C. S., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17121681 · Cited by 4 · see citing works

Centella triterpenes cream as a potential drug for the treatment of hypertrophic scar through inhibiting the phosphorylation of STAT3 : A network pharmacology analysis and in vitro experiments

Tan, M., Wu, D., Zhou, Y., & Duan, B. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15883 · Cited by 4 · see citing works

Graph Attention Network based mapping of knowledge relations between chemical spaces of Nuclear factor kappa B and Centella asiatica

Vivek, P. V., Mohanan, M., Shajil, U. K., PA, S. E., & A, J. U. C. (2023) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2023.107955 · Cited by 3 · see citing works

Centella asiatica improves sleep quality and quantity in aged mice

Dovek, L., Tinsley, C. E., Gutowsky, K., McDaniel, K. L., McGuire, N. M., Nungaray, L. R., Potter, Z., Ruffins, M., Milman, N., Wong, C., et al. (2025) · SLEEP Advances · doi:10.1093/sleepadvances/zpaf060 · Cited by 2 · see citing works

First evidence for isolation and characterization of Bacopa monnieri (L.) Wettst-derived nanovesicles with anti-neuroblastoma potential

Khongkla, E., Boonsnongcheep, P., Suwanchaikasem, P., Promthep, K., Srisaisup, M., Charuraksa, T., Makarathut, P., & Chetsawang, B. (2026) · Scientific Reports · doi:10.1038/s41598-026-55427-7 · Cited by 2 · see citing works

Mechanistic insights into the synaptic damage-repair and regeneration processes in neurodegenerative Alzheimer’s disease: phytochemicals as neuroprotective agents

Yadav, B., Gangwar, P., Kumari, K., Yadav, A., Rao, R., Kumar, K., Verma, H., Dhiman, M., & Mantha, A. K. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2026.1835778 · Cited by 2 · see citing works

Centella asiaticaeffect on traumatic brain injury: A systematic review

Rosyidi, R. M., Rusidi, H. A., Januarman, J., Priyanto, B., Wardhana, D. P. W., Rozikin, R., Wahyudi, W., & Baskoro, W. (2024) · Surgical Neurology International · doi:10.25259/sni_176_2024 · Cited by 2 · see citing works

Asiatic Acid, Quercetin, and Kaempferol From Centella asiatica as Potential Inhibitors of Alpha-1-Antichymotrypsin in Alzheimer's Disease

Chatterjee, J., Atmuri, A., Raichur, E. J., & Anil, G. (2024) · Natural Product Communications · doi:10.1177/1934578x241264637 · Cited by 2 · see citing works

Peripheral Blood DNA Methylation Changes in Response to Centella asiatica Treatment in Aged Mice

Monestime, O., Davis, B. A., Layman, C. E., Wheeler, K. J., Hack, W. R., Zweig, J. A., Soumyanath, A., Carbone, L., & Gray, N. E. (2025) · Biology · doi:10.3390/biology14010052 · Cited by 2 · see citing works

Therapeutic propensity and pharmacological Action of herbal extract in Parkinson's Disease

Amrutha, K., Verma, P., & Singh, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19084-1.00025-9 · Cited by 1 · see citing works

Molecular Contrivance of Deed of Neuroprotective Biomolecules

Pal, R. S., Pal, Y., Lagah, J., Katiyar, D., & Punniyakotti, S. (2023) · Current Drug Therapy · doi:10.2174/1574885518666230818105848 · Cited by 1 · see citing works

Madecassoside alleviates Clostridioides difficile infection by targeting ASC to inhibit inflammasome activation

Chen, W., Zhao, Y., Hu, L., Dong, D., Zeng, Y., Su, T., Shen, Y., Liu, Y., Zhao, Q., Jiang, C., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115440 · Cited by 1 · see citing works

Attenuation of IL-1β-induced inflammation in intestinal epithelial cells by Centella asiatica juice via MAPK and NF-κB signaling cascades and characterization of its key bioactive compound

Shin, H. Y., Jeong, W. B., Kim, W. J., Joung, M. Y., Shin, K.-S., & Yu, K.-W. (2025) · Food Science and Biotechnology · doi:10.1007/s10068-025-02029-0 · Cited by 1 · see citing works

Herbal Cocktail Hydrogel Film ( Garcinia mangostana , Centella asiatica , and Chromolaena odorata Extracts): A Novel Wound Dressing Approach

Sangnim, T., Panpipat, C., Manmuan, S., Leehueng, N., Suphan, W., Thuenaram, C., & Huanbutta, K. (2026) · International Journal of Biomaterials · doi:10.1155/ijbm/5576769 · Cited by 1 · see citing works

Uncovering plant-derived compounds to treat Alzheimer's disease by targeting the acetylcholinesterase enzyme through computational studies

Hasan, A. H., Rana, S., Kumer, A., Hossain, N., Sezin, S. N., Islam, M. T., Molla, N. U., Hosen, M. N., Maha, N. M., Mahi, M. M., et al. (2026) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2026.100234 · Cited by 1 · see citing works

Centella asiatica ameliorates scopolamine-induced cognitive impairment via acetylcholinesterase modulation and oxidative stress reduction

Kim, Y.-J., Kang, Y., Pak, M. E., Eom, H. J., Kim, K. Y., Hur, N., Seo, Y., Oh, T. K., Bae, J., Lee, J. K., et al. (2026) · Food Science and Biotechnology · doi:10.1007/s10068-026-02132-w · Cited by 1 · see citing works

Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging

Borowicz, K. K. (2026) · Nutrients · doi:10.3390/nu18111649 · Cited by 1 · see citing works

Huyan-I formula attenuates renal senescence and fibrosis by inhibiting STAT3/NF-κB/NLRP3-driven SASP

Wen, K., Yin, X., Sun, L., Yu, K., Huang, L., Song, Q., Liu, B., Cui, X., Tu, Y., & He, W. (2026) · Journal of Natural Medicines · doi:10.1007/s11418-026-02046-1 · Cited by 1 · see citing works

Targeting oxidative stress, senescence, and neurodegeneration: anti-aging perspectives of Urtica dioica and Centella asiatica

Dobriyal, P., Singh, V., Goel, F., & Garg, V. K. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02309-z · Cited by 1 · see citing works

Potensi Pegagan (Centella asiatica) terhadap Fungsi Kognitif Lanjut Usia

Siregar, S. R., Widyawati, T., & Ichwan, M. (2023) · AVERROUS Jurnal Kedokteran dan Kesehatan Malikussaleh · doi:10.29103/averrous.v9i1.10772 · Cited by 1 · see citing works

Design, synthesis, and anti-tumor activity of derivatives of ring A and C-28 of asiatic acid

Meng, Y., Meng, B.-B., Xu, D., Wang, Z., Li, J., & Huang, M.-Q. (2023) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2023.2253152 · Cited by 1 · see citing works

Herbs for Autoimmune Diseases

Mukne, A., Dangat, S. V., Shirodkar, P. Y., & Sawate, K. (2023) · Springer eBooks · doi:10.1007/978-981-99-7703-1_18 · Cited by 1 · see citing works

Evaluation of Cognitive and Synaptic Restoration in Diabetic Rats Treated With Emblica officinalis, Clitoria ternatea, Vitamin C, and Metformin

Morampudi, R. K., Neelakandan, V., Kumar, B. N., & Indla, E. (2024) · Cureus · doi:10.7759/cureus.75866 · Cited by 1 · see citing works

Neuroprotective Effects of Centella asiatica Against AlCl3 and D-Galactose-Induced Astrocyte Activation and Hippocampal Neurodegeneration in Male Albino Wistar Rats

Vishnumukkala, T., Boddeti, R. K., Gopalakrishna, P. K., Karikalan, B., Jagadeesan, S., Baharuldin, M. T. H., Nor, N. H. M., & Moklas, M. A. M. (2025) · International Journal of Anatomy and Research · doi:10.16965/ijar.2024.246 · Cited by 1 · see citing works

Herbal Plants for Mental Disorders in Sri Lanka

Senarathne, R. N., Jayasuriya, B. N., & Gunawardana, S. L. A. (2024) · Future Integrative Medicine · doi:10.14218/fim.2024.00024 · Cited by 1 · see citing works

A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women.

Hur, N., Seo, Y., Bae, J., Kim, Y. J., Kim, E. J., & Choi, Y. J. (2026) · Nutrients · doi:10.3390/nu18101505

MERCANTE, Marcelo S. 2012. Imagens de Cura: Ayahuasca, imaginação, saúde e doença na Barquinha

Böschemeier, A. G. E. (2013) · Anuário Antropológico · doi:10.4000/aa.450

The Effectiveness of Ethanolic Extract of Centella asiatica (L.) on Healing Minor Recurrent Aphthous Stomatitis in Wistar Male Rats (Rattus norvegicus)

Khofifah, S. D., Suparno, N. R., Sari, M., Vernanda, M. R., & Azmi, N. M. I. T. (2022) · Advances in health sciences research/Advances in Health Sciences Research · doi:10.2991/ahsr.k.220403.007

PEG-400 Nanoencapsulated Gotu Kola Leaf Extracts as an Alternative Treatment for Cognitive System Impairment: In-Vitro and In-Vivo Assays

Limantoro, B., Samuel, Naufaldy, A. N., Anggraini, R., Renatamagani, S. P., Sutami, M. F., Nyomanto, R. X., Apandi, N. I. M., & Mahdani, F. Y. (2025) · Tropical Journal of Natural Product Research · doi:10.26538/tjnpr/v9i7.22

Medicinal Plants for Autism

Ghavam, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-40858-8_404-1

PREDICTION OF MADECASSOSIDE (CENTELLA ASIATIACA) AFFINITY AS ANTIPARKINSON DRUG ON DOPAMINE RECEPTOR D1: MOLECULAR DOCKING ANALYSIS

Kusumawati, S., Khotimah, H., Endharti, A. T., Bal’afif, F., & Zakiyah, R. (2025) · MNJ (Malang Neurology Journal) · doi:10.21776/ub.mnj.2025.011.02.03

Neuroprotective potential of indian herbs in ischaemic stroke: a comprehensive review of pharmacological insights, therapeutic gaps, and future directions

Pandhare, D., & Ugale, R. R. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-02019-y

Unlocking the therapeutic potential of medicinal plants

Nand, S., Singh, P., & Goel, F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-34201-1.00010-7

Beneficial effect of Centella asiatica: Synthesis of the last 2 decades

Takahashi, C. M., Cáceda, H. A. V., & Poemape, J. (2025) · Revista Colombiana de Ciencias Químico Farmacéuticas · doi:10.15446/rcciquifa.v54n3.114481

Metabolomics-derived insights into the metabolic regulation and control of centellosides in hairy root cultures of Centella asiatica

Garcia-Baeza, A. (2023) · theses.fr (ABES) · doi:10.70675/fac89ff8z2aacz428ez92a9zc7680f67d72c

Cognitive effects of nutraceutical chocolate-based formulations enriched with Bacopa monnieri, Centella asiatica, and cocoa (Theobroma cacao) flavanols - a systematic review of neurobiological mechanisms and clinical evidencePreprint

Seneviratne, R. A. C. H., & Hoang, B. X. (2026) · Research Square · doi:10.21203/rs.3.rs-9906053/v1

Ayurvedic Herbs as neurogenesis modulators: Current understanding on their potential therapeutic relevance in enhancing neuroplasticity and cognition in aging and neurodegeneration

Muralidhara, M., Vismaya, & Kumar, V. L. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106204

Enhancement of Anti-aging Properties of Medicinal Plants Through Induced Auto-polyploidization

Bharati, R., & Fernández-Cusimamani, E. (2026) · Springer eBooks · doi:10.1007/978-981-95-8064-4_8

Neuroprotective potential of centella asiatica, cinnamon, and spirulina extracts in traumatic brain injury: a biomarker-based approach using BDNF, TNF-α, and NGF

Rohadi, Purnaning, D., Harahap, H. S., Priyanto, B., Januarman, Permatasari, L., Saputri, L. O., Rufina, A., & Rahmat, D. (2026) · Phytomedicine Plus · doi:10.1016/j.phyplu.2026.101031

Investigation of the Protective Effect of Centella asiatica Against Doxorubicin-Induced Testicular Damage in Rats

Bedir, F., Süleyman, Z., Kocatürk, H., Altay, M. S., Çimen, F. K., Altuner, D., Babayeva, M., & Süleyman, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177883

Plant-Derived Bioactive Compounds in Aging: Shared Mechanism Linking Cardiovascular and Neurodegenerative Diseases

Trigueiro, R. L., Oliveira, L. G. D. H., & Pantoja, P. D. S. (2026) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20260025

Nano-Formulated Madecassic Acid Enhances Neuroprotection Against Aβ (25–35)-Induced Oxidative Stress and Apoptotic Neurotoxicity

Sivamaruthi, B. S., Fukngoen, P., Chaiyasut, C., Kesika, P., Nallasamy, P., Suganthy, N., & Khongtan, S. (2026) · Scientia Pharmaceutica · doi:10.3390/scipharm94040091

Asiatic acid mitigates neuroinflammation and oxidative stress in Alzheimer's disease: An integrated computational and cellular study

Gupta, A., Singh, S., Gupta, S., Kumar, P., Pareek, D., Bansal, Y., Tripathi, A., Paik, P., & Singh, T. D. (2026) · Results in Chemistry · doi:10.1016/j.rechem.2026.103979

Nanoformulations of Asiatic Acid and Asiatic Acid-enriched Fraction of Centella asiatica Preserve Mitochondrial and Dopaminergic Integrity in Cellular and MPTP-induced Mouse Models of Parkinson’s Disease

Saji, C. V., Chandra, G., Mohanakumar, K. P., & Shenoi, R. A. (2026) · Neurotoxicity Research · doi:10.1007/s12640-026-00833-y

Neuropsychiatric effects and safety of Salvia species: A critical narrative review of preclinical and clinical evidence

Marwan, A.-N., & Ibraheem, F. (2026) · World Journal of Translational Medicine · doi:10.5528/wjtm.127008

Neuro-therapeutic benefits of Centella asiatica on some neurodegenerative diseases: a review

Chiroma, S. M., Moklas, M. A. M., Taib, C. N. M., Baharuldin, M. T. H., Jagadeesan, S., Amom, Z., & Ibrahim, B. (2017) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · Cited by 4 · see citing works

Centella asiatica

Jantwal, A., Durgapal, S., Upadhyay, J., Rana, M. D., Tariq, M., Dhariwal, A., & Joshi, T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819212-2.00021-9 · Cited by 6 · see citing works

A review on Centella asiatica (L.) nutrient and phytochemical composition and its potential neuroprotective effect in Alzheimer’s disease

Ganesan, V. K., Rajyalakshmi, R., Dabburu, K., Shanmugam, D. A. S., & Balaraman, A. D. (2025) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2025.100237 · Cited by 3 · see citing works

The neuroprotective properties of Centella asiatica and its possible significance in optimal agingPreprint

Smith, A. G. (2022) · doi:10.31219/osf.io/7ypb6

Recent Updates in Neuroprotective and Neuroregenerative Potential of Centella asiatica.

Lokanathan, Y., Omar, N., Puzi, N. N. A., Saim, A. B., & Idrus, R. B. H. (2016) · Europe PMC (PubMed Central) · Cited by 82 · see citing works