Neo-clerodane diterpenes and phytoecdysteroids from Ajuga decumbens Thunb. and evaluation of their effects on cytotoxic, superoxide anion generation and elastase release in vitro
Abstract
Five novel compounds, including four neoclerodane diterpenoids, named ajugacumbins KN (1-4) along with a phytoecdysterone, named ajugacetalsterone E (5), were isolated from the whole herbs of Ajuga decumbens (Labiatae). Their structures were elucidated on the basis of detailed spectroscopic analysis including IR, HRESIMS, CD, 1D and 2D NMR spectroscopic experiments. Compounds 1-5 were evaluated for their cytotoxic activities and the effects on superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils.
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Ajugacetalsterone E showed moderate cytotoxic and antioxidant activity, including inhibition of superoxide anion generation and elastase release.
“Evaluated cytotoxic activity against MCF-7, GepG2, A549, and B16 cell lines using MTT method and the inhibition of superoxide anion generation and elastase release and moderate activity have been observed.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [119]
Ajugacetalsterone E exhibited in vitro cytotoxic activity, superoxide anion generation, and elastase release in FMLP/CB-induced human neutrophils.
“A novel phytoecdysterone ajugacetalsterone E (158) exhibited in vitro cytotoxic activity, superoxide anion generation, and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophils119.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [119]
Ajugacetalsterone E and four other neoclerodane diterpenoids from A. decumbens inhibited cell proliferation of MCF-7, GepG2, A549, and B16 cell lines.
“Ajugacetalsterone E and four other neoclerodane diterpenoids from A. decumbens inhibited cell proliferation of the MCF-7, GepG2, A549, and B16 cell lines as an anticancer prospect119.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [119]
A PE isolated from Ajuga, named ajugacetalsterone E, displays cytotoxic activity, generation of superoxide anion, and elastase synthesis in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B-induced human neutrophils.
“A PE isolated from Ajuga, named ajugacetalsterone E, displays cytotoxic activity, generation of superoxide anion, and elastase synthesis in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B-induced human neutrophils [83].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [83]
PEs, e.g., ajugacetalsterone E, inhibit cell proliferation of cell lines as anticancer agents.
“PEs, e.g., ajugacetalsterone E, inhibit cell proliferation of cell lines as anticancer agents [83].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [83]
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- Authors
- Chen, H., Tang, B.-Q., Chen, L., Liang, J.-Y., & Sun, J.-B.
- Affiliations
- China Pharmaceutical University (CN)
- University of Macau (MO)
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 129
- Pages
- 7-12
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W2807224887
- Cited by
- 14
- References
- 16
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Guangxi Key Laboratory of Early Prevention (GK2015-TKF02)
- Xi'an Jiaotong University (KLTPM-SX2022-B3)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Keywords
- Ajuga decumbens, neo-clerodane diterpenoids, phytoecdysteroids, cytotoxicity, superoxide production, elastase release, structure elucidation, natural product isolation
- MeSH terms
- Diterpenes, Humans, Neutrophils, Pancreatic Elastase, Superoxides, Molecular Structure, Ajuga, Cell Line, Tumor, Diterpenes, Clerodane
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