The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Production of γ-aminobutyric acid (GABA) by Lactobacillus paracasei isolated from traditional fermented foods
Abstract
Lactobacillus strains that accumulated gamma-aminobutyric acid (GABA) in culture medium were screened to determine strains with high GABA-producing ability. One strain, NFRI 7415, which was isolated from a Japanese traditional fermented fish (funa-sushi), showed the highest GABA-producing ability among the screened strains. Identification tests (i.e., 16S rDNA sequencing and sugar assimilation ability) indicated that NFRI 7415 belongs to Lb. paracasei. The GABA production was further improved by the addition of pyridoxal phosphate to the culture medium and pH regulation of culture medium at pH 5.0. Under optimal cultivation conditions, strain NFRI 7415 produced GABA at a concentration of 302 mM when the glutamate concentration in the culture medium was 500 mM.
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“Circulation of microbe-derived neurotransmitters, including acetylcholine (Lactobacillus), GABA (Bifidobacteria and Lactobacillus), and serotonin (Enterococcus and Streptococcus), can potentially influence microglial activation through direct and indirect means (Komatsuzaki et al., 2005; Yano et al., 2015; Pokusaeva et al., 2017).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Komatsuzaki et al., 2005
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Cites
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Escherichia coli has two homologous glutamate decarboxylase genes that map to distinct loci
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Exchange of glutamate and gamma-aminobutyrate in a Lactobacillus strain
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Production of γ-Aminobutyric Acid By Cheese Starters During Cheese Ripening
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- Kandler, 1989, Regular, nonsporing gram-positive rods, vol. 2, 1208
- Kiuchi, 1990, Development of sweet sorghum silage starter, Rep. Natl. Food Res. Inst., 54, 44
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Neurotransmitter modulation by the gut microbiota
Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527
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Production of gaba (γ - aminobutyric acid) by microorganisms: a review
Dhakal, R., Bajpai, V. K., & Baek, K.-H. (2012) · Brazilian Journal of Microbiology · doi:10.1590/s1517-83822012000400001 · Cited by 545
“Effect of pH The biosynthesis of GABA in microorganisms is mainly regulated by pH, which usually has the most pronounced effect for a fermentation process (43, 83, 90).”
BackgroundMethodInfluentialMicrobiome–microglia connections via the gut–brain axis
Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471
“Circulation of microbe-derived neurotransmitters, including acetylcholine (Lactobacillus), GABA (Bifidobacteria and Lactobacillus), and serotonin (Enterococcus and Streptococcus), can potentially influence microglial activation through direct and indirect means (Komatsuzaki et al., 2005; Yano et al., 2015; Pokusaeva e…”
BackgroundGamma-aminobutyric acid as a bioactive compound in foods: A review
Diana, M., Quílez, J., & Rafecas, M. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.004 · Cited by 473
Metadata
- Authors
- Komatsuzaki, N., Shima, J., Kawamoto, S., Momose, H., & Kimura, T.
- Affiliations
- University of Tsukuba (JP)
- Food Research Institute (JP)
- Jissen Women's University (JP)
- Corresponding author
- Shima, Jun
- Venue
- Food Microbiology
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 22
- Issue
- 6
- Pages
- 497-504
- ISSN
- 0740-0020 (ISSN-L)
- OpenAlex
- W2033640624
- Cited by
- 391
- References
- 28
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 23 · 2023: 27 · 2022: 28 · 2021: 22 · 2020: 31 · 2019: 30 · 2018: 20 · 2017: 24 · 2016: 15 · 2015: 20 · 2014: 25 · 2013: 22 · 2012: 18
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Microbiology (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › GABA and Rice Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Biopolymer Synthesis and Applications
- Keywords
- GABA, Lactobacillus paracasei, GABA production, fermented fish products, traditional fermented foods, pyridoxal phosphate, culture medium pH, glutamate, lactic acid bacteria
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