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Antihypertensive, ACE-inhibitory and vasodilator properties of an egg white hydrolysate: Effect of a simulated intestinal digestion
Abstract
In previous studies we showed that the egg white hydrolysate with pepsin (HEW) and its fraction with molecular mass lower than 3000 Da (HEW < 3000) have ACE-inhibitory activity in vitro and exert antihypertensive effects after single-oral and long-term administrations to spontaneously hypertensive rats (SHR). In this paper we have simulated an intestinal digestion on HEW and HEW < 3000 and addressed its effect on their ACE-inhibitory and vasodilator activities in vitro and antihypertensive activity in vivo. The results showed that the ACE-inhibitory activity of HEW and HEW < 3000 was maintained after the simulated intestinal digestion. HEW also exerted vasodilator activity in isolated aortic rings before and after the digestion. Both activities may explain the antihypertensive effects of these products in SHR. The peptides RADHP and YPI, which were detected by RP-HPLC-MS in the hydrolysates after the action of the pancreatic enzymes, could be responsible for the antihypertensive effects. In conclusion, HEW or HEW < 3000 could be useful in the prevention and/or treatment of hypertension and other associated disorders.
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Hydrolyzed ovalbumin showed a strong ACE-inhibitory activity.
“Hydrolyzed ovalbumin showed a strong ACE-inhibitory activity (Miguel et al., 2007).”
From Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—A review (2013) · cites this paper as Miguel et al., 2007
Vasodilation effect was observed from peptides derived from egg white as well as from ovalbumin.
“Vasodilation effect (Miguel et al., 2007) was observed from the peptides derived from egg white as well as from ovalbumin.”
From Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—A review (2013) · cites this paper as Miguel et al., 2007
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Research works printed but not linked: 26
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Cited by
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Abeyrathne, E. D. N. S., Lee, H. Y., & Ahn, D. U. (2013) · Poultry Science · doi:10.3382/ps.2013-03391 · Cited by 532
“Hydrolyzed ovalbumin showed a strong ACE-inhibitory activity (Miguel et al., 2007).”
BackgroundSamarakoon, K. W., O-Nam, K., Ko, J.-Y., Lee, J.-H., Kang, M.-C., Kim, D., Lee, J. B., Lee, J.-S., & Jeon, Y.-J. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9994-6 · Cited by 116
Metadata
- Authors
- Miguel, M., Alonso, M. J., Salaices, M., Aleixandre, A., & López-Fandiño, R.
- Affiliations
- Instituto de Fermentaciones Industriales (ES)
- Universidad Rey Juan Carlos (ES)
- Universidad Complutense de Madrid (ES)
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 104
- Issue
- 1
- Pages
- 163-168
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2086441142
- Cited by
- 108
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Peptidase Inhibition and Analysis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- egg white hydrolysate, pepsin hydrolysate, ACE inhibitory activity, antihypertensive peptides, vasodilator activity, simulated intestinal digestion, spontaneously hypertensive rats, hypertension, aortic rings, bioactive peptides, small peptides
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