Cited by 16Phytochemicals and Antioxidant ActivitiesPomegranate: compositions and health benefitsFree Radicals and Antioxidants

Prevention of peroxynitrite-induced oxidation and nitration reactions by ellagic acid

Ippoushi, Katsunari, Takeuchi, Atsuko, Azuma, Keiko·2009·Food Chemistry

Abstract

Four benzoic acid derivatives and three phenylpropanoids were tested for their ability to suppress oxidation of dichlorodihydrofluorescein (DCDHF) induced by 3-morpholinosydnonimine (SIN-1, a peroxynitrite donor). Ellagic acid was found to potently inhibit this oxidation and to inhibit oxidation of DCDHF induced by peroxynitrite itself. Moreover, this compound prevented peroxynitrite-induced oxidative single strand breaks in pTZ 18U plasmid DNA and nitration of tyrosyl residues in bovine serum albumin. These results show that ellagic acid protects biomolecules against oxidative and nitrative damage induced by peroxynitrite in vitro.

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Crossref · 10.1016/j.foodchem.2008.05.057

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19 of 19 references verified0 citation errors · 0 not checkable

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  • High concentrations of NO can react with superoxide anion to produce peroxynitrite, which is involved in several disorders including lipid peroxidation, membrane destabilization, oxidation, protein nitration, and DNA damage.

    “In high concentrations NO can react with superoxide anion and produce potentially harmful peroxynitrite (Peluffo and Radi 2007), which is involved in the genesis of several disorders including induced lipid peroxidation, membrane destabilization (Virág et al. 2003), oxidation, protein nitration, and DNA damage (Ippoushi et al. 2009).”

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Authors
Ippoushi, K., Takeuchi, A., & Azuma, K.
Affiliations
National Agriculture and Food Research Organization (JP)
Corresponding author
Ippoushi, Katsunari
Venue
Food Chemistry
Publisher
Elsevier BV
Published
2009-01
Volume
112
Issue
1
Pages
185-188
ISSN
0308-8146 (ISSN-L)
OpenAlex
W2045615188
Cited by
16
References
19
Citations by year
2023: 1 · 2021: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
1.21
Type
journal article
Language
en
Open access
closed
Locations
Food Chemistry (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords
ellagic acid, peroxynitrite, oxidative DNA damage, nitration, SIN-1, benzoic acid derivatives, phenylpropanoids, tyrosine nitration, bovine serum albumin, single-strand breaks, DNA protection, antioxidants

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