Avaliação do sequestro do óxido nítrico (NO) pelo extrato metanólico da alga Bryothamnion triquetrum (Gmelin) Howe
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O excesso de óxido nítrico (NO) produzido por indução da enzima óxido nítrico sintase (iNOS) participa do desenvolvimento de inúmeras desordens que conduzem à perda da homeostasia. O estresse oxidativo gerado pelo aumento da produção endógena de NO pode levar a efeitos de toxidade induzida, tais como peroxidação lipídica, nitração de proteínas e danos ao DNA. Compostos que sejam capazes de sequestrar o radical NO podem diminuir a toxicidade das espécies reativas de nitrogênio (RNS), atuando na modulação de processos inflamatórios. Trabalhos realizados com alga da espécie Bryothamnion triquetrum (Gmelin) Howe, demonstraram que a mesma apresenta ação antioxidante, tendo sido eficiente no sequestro do radical DPPH, além de inibição da peroxidação lipídica, com uma atividade comparável ao ácido ascórbico e ao α-tocoferol. Este estudo objetivou avaliar a capacidade de sequestro do radical NO in vitro pelo extrato metanólico da Bryothamnion triquetrum. Os resultados obtidos revelaram a presença de polifenóis sendo que todas as concentrações testadas (1,0; 2,5; 7,5; 10,0 mg/mL) foram capazes de inibir a formação de nitrito a partir de uma solução de nitroprussiato de sódio 5 mM sendo a concentração de 7,5 mg/mL a que apresentou maior percentual de inibição com 46,6%.
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Natural substances such as gallic acid have an ability to scavenge nitric oxide.
“As shown by a previous study (Maia et al. 2010), natural substances such as gallic acid have an ability to scavenge nitric oxide.”
From Evaluation of chemical constituents and antioxidant activity of coconut water (Cocus nucifera L.) and caffeic acid in cell culture (2013) · cites this paper as Maia et al. 2010
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Self-citationAVALIAÇÃO DO POTENCIAL ANTI-INFLAMTÓRIO DE EXTRATOS ISOLADOS DE MICRORGANISMOS MARINHOS
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- Authors
- Maia, R. M., Moura, C. W. N., Bispo, V. S., Santos, J. L. A., Santana, R. S., & Matos, H. R.
- Affiliations
- Universidade Federal de Sergipe (BR)
- Venue
- Revista Brasileira de Farmacognosia
- Published
- 2010-09
- Volume
- 20
- Issue
- 4
- Pages
- 489-493
- ISSN
- 0102-695X (ISSN-L)
- OpenAlex
- W1616430433
- Cited by
- 7
- References
- 24
- Citations by year
- 2023: 1 · 2019: 1 · 2017: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Revista Brasileira de Farmacognosia (publishedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- nitric oxide scavenging, polyphenols, nitric oxide synthase, oxidative stress, reactive nitrogen species, sodium nitroprusside, antioxidant activity
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