Cited by 149Polysaccharides Composition and ApplicationsProbiotics and Fermented FoodsSeaweed-derived Bioactive Compounds

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Antioxidant and immunomodulatory activity of selenium exopolysaccharide produced by Lactococcus lactis subsp. lactis

Guo, Yuxing, Pan, Daodong, Li, Hua, Sun, Yangying, Zeng, Xiaoqun, Yan, Bingxiang·2013·Food Chemistry

DOI 10.1016/j.foodchem.2012.10.029

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Abstract

Exopolysaccharide (EPS) was isolated and purified from Lactococcus lactis subsp. Lactis culture broth. Selenium chloride oxide (SeCl(2)O) was added to the EPS to synthesize selenium-exopolysaccharide (Se-EPS). The in vitro and in vivo antioxidant and in vivo immunomodulatory activity of EPS and Se-EPS were compared. EPS and Se-EPS scavenged superoxide anions and hydroxyl radicals. They also increased catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, while decreasing malondialdehyde (MDA) levels in serum and in the livers of mice. Se-EPS showed stronger in vitro and in vivo antioxidant activity than were shown by EPS. The in vivo immunoenhancement activity of EPS and Se-EPS induced by cyclophosphamide (CY) treatment in immunosuppressed mice was researched. EPS and Se-EPS treatments increased macrophage phagocytosis, spleen and thymus indices and haemolytic complement activity (HC(50)). Se-EPS showed stronger immunomodulatory activity than did EPS.

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Authors: Guo, Y., Pan, D., Li, H., Sun, Y., Zeng, X., & Yan, B.
Affiliations: Nanjing Normal University (CN)
Ningbo University (CN)
Corresponding author: Pan, Daodong
ORCID: Guo, Yuxing
Pan, Daodong
Li, Hua
Zeng, Xiaoqun
Venue: Food Chemistry
Publisher: Elsevier BV
Published: 2013-05
Volume: 138
Issue: 1
Pages: 84-89
ISSN: 0308-8146 (ISSN-L)
DOI: 10.1016/j.foodchem.2012.10.029
OpenAlex: W1987288467
Cited by: 149
References: 26
Citations by year: 2026: 6 · 2025: 9 · 2024: 12 · 2023: 9 · 2022: 19 · 2021: 11 · 2020: 17 · 2019: 15 · 2018: 11 · 2017: 13 · 2016: 7 · 2015: 4 · 2014: 11 · 2013: 5
FWCI: 9.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Food Chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Natural Science Foundation of China (30972130, 31101314, 41276121)
State Science and Technology Ministry of the People’s Republic of China (2012BAK08B01)
Natural Science Foundation of Zhejiang Province (Z3110211)
Natural Science Foundation of Jiangsu Province (BK2011787)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords: Lactococcus lactis subsp. lactis, exopolysaccharides, antioxidant activity, immunomodulatory activity, superoxide radical scavenging, hydroxyl radical scavenging, antioxidant enzymes, lipid peroxidation, macrophage phagocytosis, immunosuppression, cyclophosphamide, lactic acid bacteria
MeSH terms: Animals, Antioxidants, Female, Immunologic Factors, Macrophages, Male, Mice, Inbred ICR, Phagocytosis, Polysaccharides, Bacterial, Selenium, Lactococcus lactis, Mice

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Antioxidant and immunomodulatory activity of selenium exopolysaccharide produced by Lactococcus lactis subsp. lactis

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