The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention
Open accessAbstract
Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have described the beneficial effects of dietary kaempferol in reducing the risk of chronic diseases, especially cancer. Epidemiological studies have shown an inverse relationship between kaempferol intake and cancer. Kaempferol may help by augmenting the body’s antioxidant defense against free radicals, which promote the development of cancer. At the molecular level, kaempferol has been reported to modulate a number of key elements in cellular signal transduction pathways linked to apoptosis, angiogenesis, inflammation, and metastasis. Significantly, kaempferol inhibits cancer cell growth and angiognesis and induces cancer cell apoptosis, but on the other hand, kaempferol appears to preserve normal cell viability, in some cases exerting a protective effect. The aim of this review is to synthesize information concerning the extraction of kaempferol, as well as to provide insights into the molecular basis of its potential chemo-preventative activities, with an emphasis on its ability to control intracellular signaling cascades that regulate the aforementioned processes. Chemoprevention using nanotechnology to improve the bioavailability of kaempferol is also discussed.
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Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895
Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690
The IL-4 receptor: signaling mechanisms and biologic functions
Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.701 · Cited by 1,545
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Kaempferol and inflammation: from chemistry to medicine
Devi, K. P., Malar, D. S., Nabavi, S. F., Sureda, A., Xiao, J., Nabavi, S. M., & Daglia, M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.002 · Cited by 619
Yeshi, K., Crayn, D., Ritmejerytė, E., & Wangchuk, P. (2022) · Molecules · doi:10.3390/molecules27010313 · Cited by 488
Inhibitory kinetics and mechanism of kaempferol on α-glucosidase
Peng, X., Zhang, G., Liao, Y., & Gong, D. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2015.05.088 · Cited by 398
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Garcia-Oliveira, P., Otero, P., Pereira, A. G., Chamorro, F., Carpena, M., Echave, J., Fraga-Corral, M., Simal-Gandara, J., & Prieto, M. A. (2021) · Pharmaceuticals · doi:10.3390/ph14020157 · Cited by 303
Metadata
- Authors
- Chen, A. Y., & Chen, Y. C.
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 138
- Issue
- 4
- Pages
- 2099-2107
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2054206661
- Cited by
- 994
- References
- 3
- FWCI
- 17.84
- Type
- journal article
- Language
- en
- Open access
- green
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