Protective effect of Spirulina platensis enriched in phenolic compounds against hepatotoxicity induced by CCl4
Abstract
Phenolic compounds make up the major secondary metabolites with high pharmaceutical potential. Microalgae were reported to contain low amounts of phenolic compounds. The present study aimed to investigate the hepatoprotective potential of biomass of Spirulina platensis enriched in phenolic compounds. The protective effects of the biomass of S. platensis with low amounts of phenolics (SP1) and with high amounts of phenolics (SP2) against CCl4-induced acute hepatotoxicity were evaluated in rats. The increased levels of ALT, AST and MDA along with decreased activities of SOD and CAT were significantly (p<0.01) ameliorated by SP2. Histological examinations revealed that SP2 was more potent than SP1 in protecting the liver from toxic injury of CCl4 and preserving the hepatocyte ultrastructure. The lesions including necrosis, lymphocyte infiltration, ballooning degeneration and hepatocyte injury as irregular lamellar organisation, dilations in endoplasmic reticulums and the presence of great number of cytoplasmic vacuolization were healed by SP2.
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Antioxidant activity accounts for the protective role of Spirulina against toxicity induced by carbon tetrachloride, metals, deltamethrin, and drugs in animal models.
“It has been suggested that the antioxidant activity accounts for the protective role of Spirulina against the toxicity induced by carbon tetrachloride (CCl4) [40], by metals (arsenic, mercuric chloride, chromium, cadmium, and fluoride) [34, 41–44], by the insecticide deltamethrin in mice [39] and rats [45]”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [40]
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- Authors
- Kepekçi, R. A., Polat, S., Çelik, A., Bayat, N., & Saygideger, S. D.
- Affiliations
- Gaziantep University (TR)
- Cukurova University (TR)
- Kahramanmaraş Sütçü İmam University (TR)
- Corresponding author
- Kepekçi, Remziye Aysun
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 141
- Issue
- 3
- Pages
- 1972-1979
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2110833220
- Cited by
- 79
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 5 · 2018: 11 · 2017: 11 · 2016: 5 · 2015: 8 · 2014: 4
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
- Keywords
- Spirulina platensis, phenolic compounds, hepatoprotection, carbon tetrachloride, hepatotoxicity, microalgal biomass, antioxidant enzymes, lipid peroxidation, liver histopathology, liver necrosis
- MeSH terms
- Alanine Transaminase, Animals, Antioxidants, Aspartate Aminotransferases, Carbon Tetrachloride, Glutathione, Glutathione Peroxidase, Humans, Liver, Male, Malondialdehyde, Phenols, Superoxide Dismutase, Rats, Wistar, Protective Agents, Rats, Spirulina, Chemical and Drug Induced Liver Injury
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