Phenyllactic acid: A green compound for food biopreservation
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Phenyllactic acid is an organic acid and natural metabolite of lactic acid bacteria with antimicrobial activity and non-cytotoxicity.
“Phenyllactic acid (PLA) is an organic acid and natural metabolite of Lactic Acid Bacteria known for its antimicrobial activity and non-cytotoxicity (Rajanikar et al. 2021).”
From Antifungal Potential of Chitosan and Phenyllactic Acid against Colletotrichum gloeosporioides, the Anthracnose Pathogen in Avocados (2025) · cites this paper as Rajanikar et al. 2021
PLA probably enters the cell membrane, dissociates inside, and releases protons, making the cell acidic and depolarizing its membrane.
“In contrast, PLA likely penetrates the cell membrane and dissociates intracellularly, releasing protons that acidify the cell and depolarize the membrane.”
From Antifungal Potential of Chitosan and Phenyllactic Acid against Colletotrichum gloeosporioides, the Anthracnose Pathogen in Avocados (2025) · cites this paper as Rajanikar et al. 2021
The resulting loss of electrochemical balance blocks essential enzymes and metabolic pathways, causing cell death.
“This disrupts the cell's electrochemical balance, leading to key enzyme and metabolic pathways essential for cell survival inhibition and, ultimately, cell death (Guo et al. 2021;Ning et al. 2021;Rajanikar et al. 2021;Fan et al. 2022;Li et al. 2022;Zhang et al. 2024).”
From Antifungal Potential of Chitosan and Phenyllactic Acid against Colletotrichum gloeosporioides, the Anthracnose Pathogen in Avocados (2025) · cites this paper as Rajanikar et al. 2021
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References 170 · Cited by 124
- Authors
- Rajanikar, R. V., Nataraj, B. H., Naithani, H., Ali, S. A., Panjagari, N. R., & Behare, P. V.
- Affiliations
- National Dairy Research Institute (IN)
- Corresponding author
- Behare, Pradip V.
- ORCID
- Venue
- Food Control
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 128
- Pages
- 108184
- ISSN
- 0956-7135 (ISSN-L)
- OpenAlex
- W3154959545
- Cited by
- 124
- References
- 170
- Citations by year
- 2026: 25 · 2025: 26 · 2024: 23 · 2023: 17 · 2022: 24 · 2021: 9
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Food Control (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Fermentation and Sensory Analysis
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- phenyllactic acid, lactic acid bacteria, food biopreservation, antimicrobial agents, whole-cell biocatalysis, biosynthetic pathway, phenylalanine metabolism, anti-virulence activity, spoilage microorganisms, food safety, toxicology
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