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Cited by 86Phytochemicals and Antioxidant ActivitiesPhytochemistry and Biological ActivitiesMedicinal Plant Research

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Seasonal variation in phenolic composition and antioxidant and anti-inflammatory activities of Calamintha nepeta (L.) Savi

Pacifico, Severina, Galasso, Silvia, Piccolella, Simona, Kretschmer, Nadine, Pan, San-Po, Marciano, Sabina, Bauer, Rudolf, Monaco, Pietro·2015·Food Research International
DOI 10.1016/j.foodres.2014.12.019
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Abstract

Calamintha nepeta (L.) Savi (Lamiaceae) is a small culinary and medicinal aromatic herb, native to the Mediterranean region, traditionally used for its diaphoretic, expectorant, febrifuge and stomachic properties. In order to carry out a thorough chemical and biological screening of the plant and to explore phenophase influence on its polyphenol content, samples of the plant were collected at different phases during its life cycle (July/October 2012 and January/April 2013). Each sample, previously extracted using a hydroalcoholic solution, was analyzed for its phenol contents through LC–DAD–ESI-MS/MS techniques. Acacetin and caffeic acid derivatives were the main constituents and the relative abundance of each identified metabolite seemed to be strongly collection time dependent. The evaluation of the antioxidant capacity of the investigated hydroalcoholic extracts was carried out performing different tests. Relative Antioxidant Capacity Index (RACI) was also calculated. Although extract from the summer collection exerted the highest antioxidant capability in cell-free systems, when cytoprotective and anti-inflammatory activities were assessed, extract from the winter collection was the most active sample. In particular, it was capable to inhibit COX-2 synthesis by 40.10%; dexamethasone, used as positive control, exerted a similar activity. Comparing phenol profiling data to bioactivity ones, it was highlighted that the winter extract contained an amount of acacetin and its derivatives nearly four times than those of caffeic acid derivatives.

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Crossref · 10.1016/j.foodres.2014.12.019

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Citations

Cites

Research works printed but not linked: 2

  1. Sarosi, 2012, Fattori che influenzano l'accumulo di antiossidanti in piante aromatiche, Italus Hortus, 19, 51
  2. Verma, 2011, Studies on antiulcer activity of essential oil of Calamintha officinalis Moench, International Journal of Research in Pharmaceutical Science, 2, 2733

Cited by

See all 86

Metadata

Authors
Pacifico, S., Galasso, S., Piccolella, S., Kretschmer, N., Pan, S.-P., Marciano, S., Bauer, R., & Monaco, P.
Affiliations
  • University of Campania "Luigi Vanvitelli" (IT)
  • University of Graz (AT)
Corresponding author
Pacifico, Severina
ORCID
Venue
Food Research International
Publisher
Elsevier BV
Published
2015-03
Volume
69
Pages
121-132
ISSN
0963-9969 (ISSN-L)
DOI
10.1016/j.foodres.2014.12.019
OpenAlex
W1966000673
Cited by
86
References
51
Citations by year
2026: 4 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 18 · 2021: 6 · 2020: 10 · 2019: 10 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 4
FWCI
3.74
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Food Research International (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
Calamintha nepeta, phenolic composition, seasonal variation, antioxidant activity, anti-inflammatory activity, acacetin, caffeic acid derivatives, polyphenols, COX-2 inhibition, hydroalcoholic extract, medicinal plants, Lamiaceae

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.