Cited by 165Phytochemistry and Biological ActivitiesTraditional Chinese Medicine AnalysisPlant chemical constituents analysis

Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry

Han, Jian, Ye, Min, Qiao, Xue, Xu, Man, Wang, Bao-rong, Guo, De-An·2008·Journal of Pharmaceutical and Biomedical Analysis

Abstract

A simple and rapid method has been established for the screening of the main phenolic compounds in Artemisia annua by LC-DAD-ESI-MS(n). A total of 40 phenolic compounds were identified or tentatively characterized in the methanol extract of A. annua, including 8 C-glycosyl flavonoids, 5 O-glycosyl flavonoids, 3 flavonoid aglycones, 21 quinic acid derivatives, 2 benzoicacid glucosides and 1 coumarin. The C-glycosyl flavonoids were reported from A. annua for the first time and they were found to be a new type of main constituents, and might be responsible for its antioxidant and antiviral activity. Quinic acid derivatives were also found to be the major constituents of A. annua.

Integrity signals

Registry

Crossref · 10.1016/j.jpba.2008.02.013

Cites

29 of 29 references verified0 citation errors · 0 not checkable

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  • Compounds 166-182 are esters formed by various combinations of ferulic and cinnamic acid with the four hydroxyl groups of quinic acid and were isolated from a single HPLC-MS study.

    “Compounds 166-182 (Table 16), which are esters formed by various combinations of ferulic and cinnamic acid with the four hydroxyl groups of quinic acid, were isolated from a single HPLC-MS study [71].”

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Authors
Han, J., Ye, M., Qiao, X., Xu, M., Wang, B.-R., & Guo, D.-A.
Affiliations
Peking University (CN)
Corresponding author
Guo, De-An
Venue
Journal of Pharmaceutical and Biomedical Analysis
Publisher
Elsevier BV
Published
2008-07
Volume
47
Issue
3
Pages
516-525
ISSN
0731-7085 (ISSN-L)
OpenAlex
W2029149449
Cited by
165
References
29
Citations by year
2026: 5 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 14 · 2018: 9 · 2017: 11 · 2016: 4 · 2015: 7 · 2014: 17 · 2013: 8 · 2012: 7
FWCI
9.68
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pharmaceutical and Biomedical Analysis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
Keywords
Artemisia annua, phenolic compounds, C-glycosyl flavonoids, flavonoid aglycones, quinic acid derivatives, coumarins, methanol extract, antioxidant activity, antiviral activity, Chinese herbal medicine
MeSH terms
Chromatography, High Pressure Liquid, Glycosides, Plant Extracts, Quinic Acid, Spectrometry, Mass, Electrospray Ionization, Artemisia annua, Flavones

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