Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry
Abstract
A simple and rapid method has been established for the screening of the main phenolic compounds in Artemisia annua by LC-DAD-ESI-MS(n). A total of 40 phenolic compounds were identified or tentatively characterized in the methanol extract of A. annua, including 8 C-glycosyl flavonoids, 5 O-glycosyl flavonoids, 3 flavonoid aglycones, 21 quinic acid derivatives, 2 benzoicacid glucosides and 1 coumarin. The C-glycosyl flavonoids were reported from A. annua for the first time and they were found to be a new type of main constituents, and might be responsible for its antioxidant and antiviral activity. Quinic acid derivatives were also found to be the major constituents of A. annua.
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Compounds 166-182 are esters formed by various combinations of ferulic and cinnamic acid with the four hydroxyl groups of quinic acid and were isolated from a single HPLC-MS study.
“Compounds 166-182 (Table 16), which are esters formed by various combinations of ferulic and cinnamic acid with the four hydroxyl groups of quinic acid, were isolated from a single HPLC-MS study [71].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [71]
Cites
Hierarchical Scheme for LC-MSn Identification of Chlorogenic Acids
Clifford, M. N., Johnston, K. L., Knight, S., & Kuhnert, N. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf026187q · Cited by 1,264 · see citing works
Fabre, N., Rustan, I., de Hoffmann, E., & Quetin‐Leclercq, J. (2001) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(01)00226-4 · Cited by 853 · see citing works
Waridel, P., Wolfender, J., Ndjoko, K., Hobby, K., Major, H. J., & Hostettmann, K. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)00806-8 · Cited by 310 · see citing works
Ferreres, F., Silva, B. M., Andrade, P. B., et al. (2003) · Phytochemical Analysis · doi:10.1002/pca.727 · Cited by 302 · see citing works
Ye, M., Han, J., Chen, H., Zheng, J., & Guo, D. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.08.009 · Cited by 265 · see citing works
Self-citationPrenylflavonoids from Humulus lupulus
Stevens, J. F., Ivancic, M., Hsu, V. L., et al. (1997) · Phytochemistry · doi:10.1016/s0031-9422(96)00744-3 · Cited by 260 · see citing works
Schütz, K., Kammerer, D. R., Carle, R., et al. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1767 · Cited by 239 · see citing works
Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall
Hưng, T. M., Na, M., Thương, P. T., Sự, N. D., Sok, D., Song, K. S., Seong, Y. H., & Bae, K. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.04.029 · Cited by 236 · see citing works
Lai, J.-P., Lim, Y. H., Su, J., Shen, H.-M., & Ong, C. N. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.10.028 · Cited by 189 · see citing works
Ye, M., Yan, Y., & Guo, D. (2005) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1944 · Cited by 180 · see citing works
Self-citationAntiviral activities of flavonoids and organic acid from Trollius chinensis Bunge
Li, Y.-L., Ma, S.-C., Yang, Y.-T., et al. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00410-x · Cited by 161 · see citing works
A tandem mass spectrometric study of selected characteristic flavonoids
Hughes, R. J., Croley, T. R., Metcalfe, C. D., et al. (2001) · International Journal of Mass Spectrometry · doi:10.1016/s1387-3806(01)00451-1 · Cited by 151 · see citing works
Matsuda, H., Morikawa, T., Toguchida, I., et al. (2002) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.50.972 · Cited by 150 · see citing works
Ma, Y., Vedernikova, I. V., den Heuvel, H. V., et al. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(99)00133-6 · Cited by 141 · see citing works
Kim, H. J., & Lee, Y. S. (2005) · Planta Medica · doi:10.1055/s-2005-873115 · Cited by 121 · see citing works
de Rijke, E., Zappey, H. W., Ariese, F., Gooijer, C., & Brinkman, U. A. T. (2002) · Journal of Chromatography A · doi:10.1016/s0021-9673(02)01868-x · Cited by 116 · see citing works
Stermitz, F. R., Scriven, L. N., Tegos, G., & Lewis, K. (2002) · Planta Medica · doi:10.1055/s-2002-36347 · Cited by 114 · see citing works
Pereira, C. A. M., Yariwake, J. H., & McCullagh, M. (2005) · Phytochemical Analysis · doi:10.1002/pca.820 · Cited by 109 · see citing works
Liu, R., Ye, M., Guo, H., Bi, K., & Guo, D. (2005) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1936 · Cited by 108 · see citing works
Self-citationChemistry, Occurrence and Biosynthesis ofC-Glycosyl Compounds in Plants
Franz, G., & Grün, M. (1983) · Planta Medica · doi:10.1055/s-2007-969972 · Cited by 95 · see citing works
Orhan, D. D., Aslan, M., Aktay, G., Ergun, E., Yeşilada, E., & Ergun, F. (2003) · Life Science · doi:10.1016/s0024-3205(03)00117-6 · Cited by 94 · see citing works
Qimin, L., den Heuvel, H. V., Delorenzo, O., et al. (1991) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(91)80597-6 · Cited by 83 · see citing works
Xiang, T., Xiong, Q., Ketut, A. I., et al. (2001) · Planta Medica · doi:10.1055/s-2001-14337 · Cited by 72 · see citing works
AntihepatotoxicC-Glycosylflavones from the Leaves ofAllophyllus edulisvar.edulisandgracilis
Hoffmann-Bohm, K., Lotter, H. L., Seligmann, O., et al. (1992) · Planta Medica · doi:10.1055/s-2006-961546 · Cited by 72 · see citing works
A fragmentation study of a flavone triglycoside, kaempferol‐3‐ O ‐robinoside‐7‐ O ‐rhamnoside
March, R. E., Miao, X., & Metcalfe, C. D. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1428 · Cited by 62 · see citing works
Antithyroid effects in vivo and in vitro of vitexin: a C-glucosylflavone in millet.
Gaitán, E., Cooksey, R. C., Legan, J. S., et al. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7714083 · Cited by 57 · see citing works
Soluble phenolic constituents from Cuscuta reflexa and Cuscuta platyloba
Löffler, C., Sahm, A., Wray, V., et al. (1995) · Biochemical Systematics and Ecology · doi:10.1016/0305-1978(95)93846-u · Cited by 45 · see citing works
Gonnet, J.-F. (1993) · Biochemical Systematics and Ecology · doi:10.1016/0305-1978(93)90030-u · Cited by 23 · see citing works
Flavonoid C-glycosides from Centaurea solstitialis L. flowers
Kamanzi, K., Raynaud, J., & Voirin, B. (1983) · Cited by 7 · see citing works
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The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works
- Authors
- Han, J., Ye, M., Qiao, X., Xu, M., Wang, B.-R., & Guo, D.-A.
- Affiliations
- Peking University (CN)
- Corresponding author
- Guo, De-An
- Venue
- Journal of Pharmaceutical and Biomedical Analysis
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 47
- Issue
- 3
- Pages
- 516-525
- ISSN
- 0731-7085 (ISSN-L)
- OpenAlex
- W2029149449
- Cited by
- 165
- References
- 29
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 14 · 2018: 9 · 2017: 11 · 2016: 4 · 2015: 7 · 2014: 17 · 2013: 8 · 2012: 7
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmaceutical and Biomedical Analysis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Keywords
- Artemisia annua, phenolic compounds, C-glycosyl flavonoids, flavonoid aglycones, quinic acid derivatives, coumarins, methanol extract, antioxidant activity, antiviral activity, Chinese herbal medicine
- MeSH terms
- Chromatography, High Pressure Liquid, Glycosides, Plant Extracts, Quinic Acid, Spectrometry, Mass, Electrospray Ionization, Artemisia annua, Flavones
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