Saccharina japonica Ethanol Extract Ameliorates Depression/Anxiety-Like Behavior by Inhibiting Inflammation, Oxidative Stress, and Apoptosis in Dextran Sodium Sulfate Induced Ulcerative Colitis Mice
Open accessAbstract
Saccharina japonica is a common marine vegetable in East Asian markets and has a variety of health benefits. This study was focused on the anti-depressant/anxiety effects of Saccharina japonica ethanol extract (SJE) on dextran sodium sulfate (DSS)-induced mice and its potential mechanism in their brain. Male C57BL/6 mice were treated with mesalazine and various doses of SJE (1, 2, and 4 g/kg body weight) for 2 weeks, followed by DSS treatment at the second week. The DSS-induced mice showed depression/anxiety-like behavior, which included shorter path length in the open field test and longer immobility time in the tail suspension test. L-SJE alleviated the depression-like behaviors. In the DSS-induced mice, reduced synaptic plasticity activated microglia, increased proinflammatory cytokines, decreased anti-inflammatory cytokine, and increased expression levels of Toll-like receptors-4, nuclear factor kappa-B, NOD-like receptors 3, apoptosis-associated speck-like protein, and Caspase-1 were observed, most of which were alleviated by SJE treatment. Furthermore, all the SJE groups could significantly enhance superoxide dismutase activity, while the L-SJE treatment decreased the contents of malondialdehyde, and the H-SJE treatment inhibited apoptosis. All these results showed that the SJE might serve as a nutritional agent for protecting the brain in ulcerative colitis mice.
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A diet containing high content of phenols, anthocyanins, and vitamin C improves symptoms of depression mainly by reducing level of oxidative damage, increasing levels and activity of antioxidant enzymes such as SOD and GPx, and increasing level of expression of glutathione.
“A diet containing high content of phenols, anthocyanins, and vitamin C improves symptoms of depression mainly by reducing the level of oxidative damage (biomarkers) in the brain, increasing levels and activity of antioxidant enzymes such as SOD and GPx, and increasing the level of expression of glutathione (Dong et al. 2021).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Dong et al. 2021
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
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- Authors
- Dong, X., Lu, K., Lin, P., Che, H., Li, H., Song, L., Yang, X., & Xie, W.
- Affiliations
- Qingdao University of Science and Technology (CN)
- Corresponding author
- Xie, Wancui
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2021-12-16
- Volume
- 8
- Pages
- 784532-784532
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC8716690
- OpenAlex
- W4200042551
- Cited by
- 27
- References
- 50
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 3
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Key Research and Development Program of China
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- Laminaria japonica, depression-like behavior, anxiety-like behavior, ulcerative colitis, DSS-induced colitis, neuroinflammation, oxidative stress, apoptosis, microglia, TLR4, inflammasome, inflammatory cytokines, superoxide dismutase, malondialdehyde, 5-aminosalicylic acid, neuroprotection
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