The DOI matches its Crossref record; 254 of the 255 references it cites were found in a registry or an index.
A critical review of antibiotic resistance in probiotic bacteria
Abstract
Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit upon the host. At present, probiotics are gaining popularity worldwide and are widely used in food and medicine. Consumption of probiotics is increasing with further in-depth research on the relationship between intestinal flora and host health. Most people pay more attention to the function of probiotics but ignore their potential risks, such as infection and antibiotic resistance transfer to pathogenic microbes. Physiological functions, effects and mechanisms of action of probiotics were covered in this review, as well as the antibiotic resistance phenotypes, mechanisms and genes found in probiotics. Typical cases of antibiotic resistance of probiotics were also highlighted, as well as the potential risks (including pathogenicity, infectivity and excessive immune response) and corresponding strategies (dosage, formulation, and administration route). This timely study provides an avenue for further research, development and application of probiotics.
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Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,443
Guidelines for the evaluation of probiotics in food
Who, F. (2002) · Medical Entomology and Zoology · Cited by 1,843
Mechanisms of action of probiotics
Plaza-Diaz, J., Ruiz-Ojeda, F. J., Gil-Campos, M., & Gil, A. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy063 · Cited by 1,423
Besselink, M. G., van Santvoort, H. C., Buskens, E., Boermeester, M. A., van Goor, H., Timmerman, H. M., Nieuwenhuijs, V. B., Bollen, T. L., van Ramshorst, B., Witteman, B. J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60207-x · Cited by 1,367
Probiotic Mechanisms of Action
Bermúdez-Brito, M., Plaza‐Díaz, J., Muñoz‐Quezada, S., Gómez‐Llorente, C., & Gil, Á. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000342079 · Cited by 1,326
Hemarajata, P., & Versalovic, J. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12459294 · Cited by 1,083
Probiotics and the gut microbiota in intestinal health and disease
Gareau, M. G., Sherman, P. M., & Walker, W. A. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.117 · Cited by 907
Demonstration of safety of probiotics—A review
Salminen, S. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00128-7 · Cited by 884
Research works printed but not linked: 2
- Ibrahim, 2015, Enterococcus: An emerging global superbug, International Journal of Science and Research, 4, 1539
- Li, 2018, Evaluating the safety of potential probiotic Enterococcus durans KLDS6.0930 using whole genome sequencing and oral toxicity study. Frontiers in, Microbiology, 9, 1943
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Mahendrarajan, V., & Easwaran, N. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107649 · Cited by 4
Terlizzi, M., Speranza, B., Sinigaglia, M., Corbo, M. R., & Bevilacqua, A. (2025) · Microorganisms · doi:10.3390/microorganisms13071647 · Cited by 4
Wang, X., Li, Q., Lai, W., Xie, A., Zhang, M., Hu, K., Li, J., Li, Q., Zhao, N., Ao, X., et al. (2025) · International Dairy Journal · doi:10.1016/j.idairyj.2025.106400 · Cited by 4
Self-citationKalagatur, N. K., Kamasani, J. R., Siddaiah, C. N., & Kadirvelu, K. (2025) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2025.08.012 · Cited by 4
Wang, J., Liu, Y., Zhu, C., Wang, Z., Wang, S., Fang, S., & Xu, F. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115851 · Cited by 4
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Chowdhury, A., Choudhary, M., Sharma, V., Kant, A., Vashistt, J., Garlapati, V. K., & Simal‐Gándara, J. (2023) · International Journal of Gastronomy and Food Science · doi:10.1016/j.ijgfs.2023.100670 · Cited by 4
Liu, Y., Sun, X., Zhang, J., Gao, F., Yu, L., Dong, L., Zhang, G., & Wu, C. (2022) · FEMS Microbiology Letters · doi:10.1093/femsle/fnac089 · Cited by 4
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Adeli, I., Habibi, F., Badami, N., & Abdollahi, M. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822521-9.00193-3 · Cited by 4
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Wang, N., Changhe, D., Gao, J., Du, L.-G., Zheng, D., Hao, Z., Ren, Z., & Lou, H. (2026) · Foods · doi:10.3390/foods15010131 · Cited by 3
Deng, F., Ke, L., Huang, M., Chen, M., Chen, Z., Mu, P., Shi, M., Wu, J., & Deng, Y. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141194 · Cited by 3
Yuan, Y., Teng, Y., Song, Y., Wu, H., Zhu, J., Dong, X., Xue, N., Wang, X., Xu, K., & Wang, G. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118650 · Cited by 3
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Amigh, P., Ahmadi, Y., Mohkam, M., & Shokri, D. (2024) · BioMed Research International · doi:10.1155/2024/2978083 · Cited by 3
Chaudhari, D. N., Ahire, J. J., Devkatte, A. N., & Kulthe, A. A. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10385-2 · Cited by 3
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Artanti, D., Sari, Y. E. S., Azizah, F., Purwaningsih, N. V., Rohmayani, V., & Nasrullah, D. (2021) · Iranian Journal of Microbiology · doi:10.18502/ijm.v13i3.6401 · Cited by 3
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Bonfanti, A., Silvestri, R., Novellino, E., Tenore, G. C., Schiano, E., Iannuzzo, F., Reverberi, M., Faino, L., Beccaccioli, M., Sivori, F., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13081804 · Cited by 2
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Park, S., Jeong, H., Lee, N., Kang, D., Paik, H., & Park, Y. (2026) · Food Science and Biotechnology · doi:10.1007/s10068-026-02134-8 · Cited by 1
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Frolova, A. S., Milentyeva, I., Kolpakova, D. E., Neverova, O. A., Петрович, Ю. В., & Petrov, A. (2026) · Food Processing Techniques and Technology · doi:10.21603/2074-9414-2026-1-2630 · Cited by 1
Silva, A. G. C. V. M., Mendonça, K. S., Gomes, J. E. G., Valério, L. C. S., da Silva, M. M., Silveira, M. O., Montalvo, G. S. A., de Souza, B. M. S., Filho, V. D. M. S., Mendonça, M., et al. (2026) · Brazilian Journal of Microbiology · doi:10.1007/s42770-026-01924-w · Cited by 1
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Ram, A., Bhattacharjee, D., Alam, S. M., Jana, S., & Pal, R. (2024) · Asian Journal of Pharmacy and Technology · doi:10.52711/2231-5713.2024.00054 · Cited by 1
Hillman, T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.10.455802
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Zhu, C., Huang, B., Yu, C., Che, Y., Wu, D., Wu, Y., Song, P., & Zhao, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1714597/v1
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Zhu, C., Huang, B., Yu, C., Che, Y., Wu, D., Wu, Y., Song, P., & Zhao, Y. (2026) · Research Journal of Biotechnology · doi:10.21203/rs.3.rs-1868131/v1
Yi, R., Tongji, L. I. U., Xue, R., & Yang, Z. (2023) · Food Science and Technology · doi:10.1590/fst.121422
Karolczyk, P., Kotarba, M., Świątek, M., Kaczmarek-Zalewska, A., Janicka, N., Jońca, B., Matkowski, I., & Karłowicz-Bodalska, K. (2023) · Farmacja Polska · doi:10.32383/farmpol/175122
Dışhan, A., & Gönülalan, Z. (2024) · GIDA / THE JOURNAL OF FOOD · doi:10.15237/gida.gd23139
Pava, K. C. L., Doblas, G. Z., Toledo, J. M. S., & Cruz, R. Y. D. (2024) · Tropical Journal of Natural Product Research · doi:10.26538/tjnpr/v8i6.20
Koluman, A., Njjar, M. S., Altıntaş, F., & Konukbay, A. (2024) · International Journal of Life Sciences and Biotechnology · doi:10.38001/ijlsb.1426971
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Guven, S., Akbulut, S., Akkaya, S. N., Almansour, A., Adıgüzel, G., & Adıgüzel, A. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107959
Сыромятников, М. Ю., Shabunin, S. V., Нестерова, Е. Ю., Гладких, М. И., Зверева, О. В., & Михайлов, Е. В. (2025) · BULLETIN OF VETERINARY PHARMACOLOGY · doi:10.65173/2541-8203.2025.32.3.009
Tang, Q., Hao, Y., Wang, L., Lu, C., Li, M., Si, Z., Wu, X., & Lu, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14795404
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Шабунин, С. В., Паршин, П. А., & Михалёв, В. И. (2025) · BULLETIN OF VETERINARY PHARMACOLOGY · doi:10.65173/2541-8203.2025.32.3.002
Toker, D., Toksöz, O., Berber, D., & Sesal, N. C. (2026) · Biologia · doi:10.1007/s11756-025-02098-w
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Marco, I. D., Zanetti, V. C., de Melo, A. P. Z., Ferreira, N. R. C., Camelo‐Silva, C., Silveira, J. C. S. D., Wolf, M., & Verruck, S. (2026) · Foods · doi:10.3390/foods15030547
Bachtarzi, N., Gomri, M. A., Bouziani, A. E., Bisson, G., Comuzzi, C., & Marino, M. (2026) · Archives of Microbiology · doi:10.1007/s00203-026-04770-4
Udawatte, N. S., Liu, C., Staples, R., Han, P., Kumar, P., Arumugam, T. V., Ivanovski, S., & Seneviratne, C. J. (2026) · Journal of Oral Microbiology · doi:10.1080/20002297.2026.2680793
Wang, Y., Xue, S., Tian, Z., Zhang, L., Ling, G., Song, W., Zhang, Y., & Zhang, G. (2026) · Food Science and Human Wellness · doi:10.26599/fshw.2026.9251085
Xiao, Y., Lu, Y., Hu, Y., Shi, R., 麦多, Lv, R., Pan, J., Pan, Y., Tan, J., Hao, Z., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1898323
Self-citationHuang, X., Yang, Y., Zhang, X., Wang, W., Yun, Q., Guo, S., Guo, S., Ge, J., & Chen, Z. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1894704
Mihai, C., Dumitrache, C., Ionut, T. R., POMOHACI, M. C., HASSAN, A. A. M., NICOLAE, G. C., DIGUTA, C. F., & MATEI, F. (2023) · Scientific Papers Series D Animal Science · doi:10.17930/ans2023279
Lopes, R. B., Okello, E., Tonooka, K. H., Okella, H., Pereira, R. V. V., & Silva-del-Río, N. (2026) · JDS Communications · doi:10.3168/jdsc.2026-1069
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Yang, J.-M., Hou, P., & Jia, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1905146
Coelho, M. C., Malcata, F. X., & Silva, C. C. G. (2026) · International Dairy Journal · doi:10.1016/j.idairyj.2026.106771
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Taya, J. D. C., Ontaneda, S. N. M., Llumipanta, I. E., & Fuel, M. (2026) · Lecture notes in networks and systems · doi:10.1007/978-3-032-14287-0_37
Zhang, B., Yuan, H., Li, Q., Wang, X., Sun, Q., Zhang, C., Wang, L., Li, C., & Ma, Q. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.110191
Self-citationMicrobiome-directed therapies in oncology: from animal models to clinical implementation
Skonieczna‐Żydecka, K., Marlicz, M., Kaczmarczyk, M., Łoniewski, I., Boluk, P., Ekstedt, N., Kutrzuba, K., & Marlicz, W. M. (2026) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2026.102148
Duan, L., Zhang, Y., Zhou, M., Wan, Z., Zhou, Y., 潘康成, Zeng, D., Jing, B., Shu, G., Zeng, Y., et al. (2026) · Research in Veterinary Science · doi:10.1016/j.rvsc.2026.106429
Wang, Z., Wei, Q., An, J., Xiang, Y., Ma, Z., Bo, X., & Li, H. (2026) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2026.108041
Sarkar, A., Das, R. K., Sinha, A., & Mandal, M. (2026) · Folia Microbiologica · doi:10.1007/s12223-026-01624-w
Metadata
- Authors
- Li, T., Teng, D., Mao, R., Hao, Y., Wang, X., & Wang, J.
- Affiliations
- Chinese Academy of Agricultural Sciences (CN)
- Corresponding author
- Wang, Xiumin
- Wang, Jianhua
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 136
- Pages
- 109571
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W3043165925
- Semantic Scholar
- 52ee37ae3573f432b8988f57cd6fc23bbf684cf1
- Cited by
- 172
- References
- 255
- Citations by year
- 2026: 29 · 2025: 36 · 2024: 37 · 2023: 23 · 2022: 32 · 2021: 13 · 2020: 2
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Agricultural Sciences
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- probiotics, antibiotic resistance, probiotic bacteria, antibiotic resistance genes, horizontal gene transfer, pathogenicity, immune response, route of administration, gut microbiota, health benefits
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Drug Resistance, Microbial, Probiotics
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