The DOI matches its Crossref record; 254 of the 255 references it cites were found in a registry or an index.
A critical review of antibiotic resistance in probiotic bacteria
Abstract
Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit upon the host. At present, probiotics are gaining popularity worldwide and are widely used in food and medicine. Consumption of probiotics is increasing with further in-depth research on the relationship between intestinal flora and host health. Most people pay more attention to the function of probiotics but ignore their potential risks, such as infection and antibiotic resistance transfer to pathogenic microbes. Physiological functions, effects and mechanisms of action of probiotics were covered in this review, as well as the antibiotic resistance phenotypes, mechanisms and genes found in probiotics. Typical cases of antibiotic resistance of probiotics were also highlighted, as well as the potential risks (including pathogenicity, infectivity and excessive immune response) and corresponding strategies (dosage, formulation, and administration route). This timely study provides an avenue for further research, development and application of probiotics.
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Grujović, M. Ž., Mladenović, K., Semedo‐Lemsaddek, T., Laranjo, M., Stefanović, O. D., & Kocić‐Tanackov, S. (2022) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12897 · Cited by 163
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Metadata
- Authors
- Li, T., Teng, D., Mao, R., Hao, Y., Wang, X., & Wang, J.
- Affiliations
- Chinese Academy of Agricultural Sciences (CN)
- Corresponding author
- Wang, Xiumin
- Wang, Jianhua
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 136
- Pages
- 109571
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W3043165925
- Semantic Scholar
- 52ee37ae3573f432b8988f57cd6fc23bbf684cf1
- Cited by
- 172
- References
- 255
- Citations by year
- 2026: 29 · 2025: 36 · 2024: 37 · 2023: 23 · 2022: 32 · 2021: 13 · 2020: 2
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Agricultural Sciences
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- probiotics, antibiotic resistance, probiotic bacteria, antibiotic resistance genes, horizontal gene transfer, pathogenicity, immune response, route of administration, gut microbiota, health benefits
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Drug Resistance, Microbial, Probiotics
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