Cited by 329Stress Responses and CortisolForensic Toxicology and Drug AnalysisAdrenal Hormones and Disorders

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An assessment of cortisol analysis in hair and its clinical applications

Gow, R., Thomson, S., Rieder, M., Van Uum, S., Koren, G.·2010·Forensic Science International

DOI 10.1016/j.forsciint.2009.12.040

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Abstract

Hair analyses for exogenous compounds, specifically drugs of abuse, have been a useful tool in detecting long-term drug exposure. More recently, studies have delved into the exposure of endogenous compounds in hair. Cortisol is synthesized in the adrenal cortex in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis. While catecholamines generally indicate acute stress, cortisol can be used as an indicator for sub-acute and chronic stress. Studies on the effects of chronic stress are most often subjective in nature, relying on questionnaires asking the participant to recall on past stressors. This can lead to the issue of recall and reporting bias. A new objective measure of chronic stress is needed for a more accurate understanding of the effects of chronic stress on the body. This review uses emerging evidence to describe the usefulness of hair analysis for cortisol and discusses the current methods used.

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Authors: Gow, R., Thomson, S., Rieder, M., Van Uum, S., & Koren, G.
Affiliations: Western University (CA)
Corresponding author: Koren, G.
ORCID: Rieder, M.
Koren, G.
Venue: Forensic Science International
Publisher: Elsevier BV
Published: 2010-03
Volume: 196
Issue: 1-3
Pages: 32-37
ISSN: 0379-0738 (ISSN-L)
DOI: 10.1016/j.forsciint.2009.12.040
OpenAlex: W2127194071
Cited by: 329
References: 31
Citations by year: 2026: 10 · 2025: 14 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 18 · 2020: 24 · 2019: 26 · 2018: 21 · 2017: 26 · 2016: 22 · 2015: 26 · 2014: 17 · 2013: 20 · 2012: 27
FWCI: 9.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Forensic Science International (publishedVersion)
PubMed (publishedVersion)
Funders: Physicians' Services Incorporated Foundation
Canadian Institutes of Health Research
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: cortisol, hair analysis, chronic stress, hypothalamic-pituitary-adrenal axis, endogenous biomarkers, stress biomarkers, recall bias, adrenal cortex, forensic toxicology
MeSH terms: Animals, Chromatography, Gas, Enzyme-Linked Immunosorbent Assay, Hair, Humans, Hydrocortisone, Radioimmunoassay, Mass Spectrometry, Stress, Physiological, Stress, Psychological, Biomarkers

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An assessment of cortisol analysis in hair and its clinical applications

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