Potential problems with the interpretation of hair analysis results
Abstract
Due to differences in hair growth rate depending on anatomical region, age, gender, ethnicity and interindividual variability, interpretation of parent drug or/and metabolite concentrations in hair is not easy. Furthermore, as drug incorporation mechanisms into hair matrix is not yet fully understood, it is rather difficult to extrapolate details on time and dose from hair segment analysis. If incorporation sources other than from bloodstream (skin secretions and/or external/environmental contamination) are considered, interpretation becomes even more complicated. For evaluating possible passive contamination, it is essential to consider specific identification of metabolites, use of metabolite-to-parent drug ratios, assays of decontamination washes and analysis of specimens collected from other body parts. Cosmetic hair treatment, natural and artificial hair colour, differences in hair structure and specificity of analytical methodology may represent other bias sources affecting concentrations of drugs in hair. A suitable cut-off level related to the LOD will allow correct identification of drugs or metabolites in hair. Regarding the performance of different hair testing laboratories, little information is available at this time to what extent test results are comparable and their interpretation is consistent. Frequency of drug consumption and time intervals between multiple consumption or lag time between consumption and appearance in the hair has not been fully investigated and needs further research.
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A hair growth rate of 1cm/month has been generally accepted in the literature for a 1-cm hair segment.
“Hair growth rates vary between individuals (Schütz et al., 1993), but a rate of 1cm/month has been generally accepted in the literature for a 1–cm hair segment (Schütz et al., 1993; Wennig, 2000).”
From Chronic Stress, Hair Cortisol and Depression: A Prospective and Longitudinal Study of Medical Internship (2018) · cites this paper as Wennig, 2000
Analyzing 3 cm of hair from the scalp provides an indication of physiological stress levels over 3 months, based on an average hair growth rate of 1 cm/month.
“Based on an average hair growth rate of 1 cm/month [73], this will give an indication of physiological stress levels over 3 months.”
Cites
Hair Analysis for Drugs of Abuse
Baumgartner, W., Hill, V., & BLAHD, W. H. (1989) · Journal of Forensic Sciences · doi:10.1520/jfs12787j · Cited by 473 · see citing works
Anatomy and physiology of hair
Harkey, M. R. (1993) · Forensic Science International · doi:10.1016/0379-0738(93)90255-9 · Cited by 380 · see citing works
Mechanisms of drug incorporation into hair
Henderson, G. L. (1993) · Forensic Science International · doi:10.1016/0379-0738(93)90256-a · Cited by 331 · see citing works
Cone, E. J. (1990) · Journal of Analytical Toxicology · doi:10.1093/jat/14.1.1 · Cited by 189 · see citing works
Cone, E. J., Yousefnejad, D., Darwin, W. D., & Maguire, T. (1991) · Journal of Analytical Toxicology · doi:10.1093/jat/15.5.250 · Cited by 187 · see citing works
Hartung, R. (1987) · Springer eBooks · doi:10.1007/978-1-4684-5290-7_3 · Cited by 176 · see citing works
Kintz, P. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-318-9_4 · Cited by 171 · see citing works
Mechanisms of Drug Incorporation into Hair
Cone, E. J. (1996) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199608000-00022 · Cited by 156 · see citing works
Henderson, G. L., Harkey, M. R., Zhou, C., Jones, R. T., & Jacob, P. (1996) · Journal of Analytical Toxicology · doi:10.1093/jat/20.1.1 · Cited by 145 · see citing works
Sachs, H., & Kintz, P. (1998) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00168-6 · Cited by 138 · see citing works
On cosmetically treated hair — aspects and pitfalls of interpretation
Skopp, G., Pötsch, L., & Moeller, M. R. (1997) · Forensic Science International · doi:10.1016/s0379-0738(96)02047-6 · Cited by 124 · see citing works
Welch, M. J., Sniegoski, L. T., Allgood, C. C., & Habram, M. (1993) · Journal of Analytical Toxicology · doi:10.1093/jat/17.7.389 · Cited by 114 · see citing works
Illegal and Therapeutic Drug Concentrations in Hair Segments - A Timetable of Drug Exposure?
Pragst, F., Rothe, M., Spiegel, K., & Sporkert, F. (1998) · PubMed · Cited by 96 · see citing works
Biochemical approach on the conservation of drug molecules during hair fiber formation
Pötsch, L., Skopp, G., & Moeller, M. R. (1997) · Forensic Science International · doi:10.1016/s0379-0738(96)02045-2 · Cited by 87 · see citing works
Drug Concentrations in Human Hair after Bleaching
Cirimele, V., Kintz, P., & Mangin, P. J. (1995) · Journal of Analytical Toxicology · doi:10.1093/jat/19.5.331 · Cited by 83 · see citing works
Influence of bleaching on stability of benzodiazepines in hair
Yegles, M., Marson, Y., & Wennig, R. (2000) · Forensic Science International · doi:10.1016/s0379-0738(99)00152-8 · Cited by 76 · see citing works
Sachs, H. (1997) · Forensic Science International · doi:10.1016/s0379-0738(96)02043-9 · Cited by 75 · see citing works
(1997) · Forensic Science International · doi:10.1016/s0379-0738(96)02042-7 · Cited by 73 · see citing works
Concordance between self-reported drug use and findings in hair about cocaine and heroin
Pépin, G., & Gaillard, Y. (1997) · Forensic Science International · doi:10.1016/s0379-0738(96)02046-4 · Cited by 63 · see citing works
Quality control by the Society of Hair Testing
Sachs, H. (1997) · Forensic Science International · doi:10.1016/s0379-0738(96)02057-9 · Cited by 46 · see citing works
Drug accumulation in melanin: an affinity chromatographic study
Knörle, R., Schniz, E., & Feuerstein, T. J. (1998) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00242-4 · Cited by 44 · see citing works
Nakahara, Y., Kikura, R., Yasuhara, M., & Mukai, T. (1997) · Forensic Science International · doi:10.1016/s0379-0738(96)02059-2 · Cited by 43 · see citing works
Mieczkowski, T. (1997) · Forensic Science International · doi:10.1016/s0379-0738(96)02052-x · Cited by 39 · see citing works
Pharmacological studies on meprobamate incorporation in human beard hair
Kintz, P., Tracqui, A., & Mangin, P. J. (1993) · International Journal of Legal Medicine · doi:10.1007/bf01370386 · Cited by 35 · see citing works
Nakahara, Y., Takahashi, K., & Konuma, K. (1993) · Forensic Science International · doi:10.1016/0379-0738(93)90265-c · Cited by 29 · see citing works
Huestis, M. A. (1996) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199608000-00025 · Cited by 25 · see citing works
Hair Analysis as Evidence in Forensic Cases
Moeller, M. R. (1996) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199608000-00023 · Cited by 20 · see citing works
Quantitation of Cocaine in Human Hair: The Effect of Centrifugation of Hair Digests
Höld, K. M., Hubbard, D. L., Wilkins, D. G., & Rollins, D. E. (1998) · Journal of Analytical Toxicology · doi:10.1093/jat/22.6.414 · Cited by 19 · see citing works
Interlaboratory Studies on the Analysis of Hair for Drugs of Abuse: Results from the Fourth Exercise
Sniegoski, L. T., & Welch, M. J. (1996) · Journal of Analytical Toxicology · doi:10.1093/jat/20.4.242 · Cited by 19 · see citing works
Plasma Protein Binding of Phenylacetate and Phenylbutyrate, Two Novel Antineoplastic Agents
Boudoulas, S., Lush, R. M., McCall, N. A., Samid, D., Reed, E., & Figg, W. D. (1996) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199612000-00015 · Cited by 16 · see citing works
Nachweis von Arznei-und anderen Fremdstoffen in Haaren
Schütz, H., Ahrens, B., Erdmann, F., & Rochholz, G. (1993) · Pharmazie in unserer Zeit · doi:10.1002/pauz.19930220205 · Cited by 15 · see citing works
Time course of cocaine in rabbit hair
Jurado, C., Rodríguez-Vicente, C., Menéndez‐González, M., & Repetto, M. (1997) · Forensic Science International · doi:10.1016/s0379-0738(96)02049-x · Cited by 13 · see citing works
Incorporation of propyphenazone in beard hair of a migraine patient
Yegles, M., & Wennig, R. (2000) · Forensic Science International · doi:10.1016/s0379-0738(99)00174-7 · Cited by 9 · see citing works
Callaghan, R. R., Wilson, J. F., & Cartwright, J. (1996) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199612000-00017 · Cited by 7 · see citing works
Flagged first, then by citations
2 of the 36 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Russell, E., Koren, G., Rieder, M., & Van Uum, S. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.009 · Cited by 1,063 · see citing works
State of the art in hair analysis for detection of drug and alcohol abuse
Pragst, F., & Balı́ková, M. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.02.019 · Cited by 1,058 · see citing works
Analysis of cortisol in hair – State of the art and future directions
Tobias Stalder, A., & Kirschbaum, C. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.02.002 · Cited by 835 · see citing works
Hair cortisol, stress exposure, and mental health in humans: A systematic review
Staufenbiel, S. M., Penninx, B. W. J. H., Spijker, A. T., Elzinga, B. M., & van Rossum, E. F. C. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.015 · Cited by 736 · see citing works
Analysis of endogenous cortisol concentrations in the hair of rhesus macaques
Davenport, M. D., Tiefenbacher, S., Lutz, C. K., Novak, M. A., & Meyer, J. S. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2006.01.005 · Cited by 659 · see citing works
Measurement of cortisol in human Hair as a biomarker of systemic exposure
Koren, G., Grace Walsh, R. N., Tokmakejian, S., & Uum, S. H. M. V. (2007) · Clinical and investigative medicine · doi:10.25011/cim.v30i5.2894 · Cited by 578 · see citing works
Quantitative analysis of steroid hormones in human hair using a column-switching LC–APCI–MS/MS assay
Gao, W., Tobias Stalder, A., Foley, P., Rauh, M., Deng, H., & Kirschbaum, C. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.03.008 · Cited by 430 · see citing works
Physiological mechanisms determining eccrine sweat composition
Baker, L. B., & Wolfe, A. S. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04323-7 · Cited by 353 · see citing works
“2000; Wennig 2000).”
Detection of physiological concentrations of cortisol and cortisone in human hair
Raul, J.-S., Cirimele, V., Ludes, B., & Kintz, P. (2004) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.02.010 · Cited by 348 · see citing works
D'Anna‐Hernandez, K., Ross, R. G., Natvig, C. L., & Laudenslager, M. L. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.041 · Cited by 346 · see citing works
An assessment of cortisol analysis in hair and its clinical applications
Gow, R., Thomson, S., Rieder, M., Van Uum, S., & Koren, G. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2009.12.040 · Cited by 329 · see citing works
Postmortem toxicology of drugs of abuse
Drummer, O. H. (2004) · Forensic Science International · doi:10.1016/j.forsciint.2004.02.013 · Cited by 302 · see citing works
Preanalytic aspects in postmortem toxicology
Skopp, G. (2004) · Forensic Science International · doi:10.1016/j.forsciint.2004.02.012 · Cited by 292 · see citing works
Dettenborn, L., Tietze, A., Kirschbaum, C., & Stalder, T. (2012) · Stress · doi:10.3109/10253890.2012.654479 · Cited by 277 · see citing works
Intraindividual stability of hair cortisol concentrations
Stalder, T., Steudte, S., Miller, R., Skoluda, N., Dettenborn, L., & Kirschbaum, C. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.08.007 · Cited by 271 · see citing works
Hair cortisol analysis: An update on methodological considerations and clinical applications
Greff, M. J. E., Levine, J. M., Abuzgaia, A. M., Elzagallaai, A. A., Rieder, M. J., & van Uum, S. H. M. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2018.09.010 · Cited by 260 · see citing works
Short, S. J., Stalder, T., Marceau, K., Entringer, S., Moog, N. K., Shirtcliff, E. A., Wadhwa, P. D., & Buss, C. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.05.007 · Cited by 239 · see citing works
A Pilot Randomized Trial of a Companion Robot for People With Dementia Living in the Community
Liang, A., Piroth, I., Robinson, H., MacDonald, B., Fisher, M., Nater, U. M., Skoluda, N., & Broadbent, E. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.05.019 · Cited by 223 · see citing works
Horsch, A., Garthus‐Niegel, S., Ayers, S., Chandra, P. S., Hartmann, K., Vaisbuch, E., & Lalor, J. (2024) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.09.089 · Cited by 260 · see citing works
Macbeth, B. J., Cattet, M., Stenhouse, G. B., Gibeau, M. L., & Janz, D. M. (2010) · Canadian Journal of Zoology · doi:10.1139/z10-057 · Cited by 234 · see citing works
LeBeau, M. A., Montgomery, M. A., & Brewer, J. D. (2011) · Forensic Science International · doi:10.1016/j.forsciint.2011.02.015 · Cited by 231 · see citing works
Hair analysis provides a historical record of cortisol levels in Cushing's syndrome
Thomson, S., Koren, G., Fraser, L.-A., Rieder, M., Friedman, T. C., & Van Uum, S. H. M. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1220771 · Cited by 218 · see citing works
Boumba, V. A., Ziavrou, K. S., & Vougiouklakis, T. (2006) · International Journal of Toxicology · doi:10.1080/10915810600683028 · Cited by 221 · see citing works
Wosu, A. C., Valdimarsdóttir, U., Shields, A. E., Williams, D. R., & Williams, M. A. (2013) · Annals of Epidemiology · doi:10.1016/j.annepidem.2013.09.006 · Cited by 199 · see citing works
Decreased hair cortisol concentrations in generalised anxiety disorder
Steudte‐Schmiedgen, S., Tobias Stalder, A., Dettenborn, L., Klumbies, E., Foley, P., Beesdo‐Baum, K., & Kirschbaum, C. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.09.002 · Cited by 207 · see citing works
García-León, M. Á., Pérez-Mármol, J. M., Gonzalez-Pérez, R., García-Ríos, M. D. C., & Peralta-Ramírez, M. I. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.02.001 · Cited by 197 · see citing works
The Detection of Cortisol in Human Sweat
Russell, E., Koren, G., Rieder, M. J., & Uum, S. H. M. V. (2013) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e31829daa0a · Cited by 195 · see citing works
Appenzeller, B. M. R., & Tsatsakis, A. M. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.10.021 · Cited by 193 · see citing works
Steudte, S., Kirschbaum, C., Gao, W., Alexander, N., Schönfeld, S., Hoyer, J., & Stalder, T. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.011 · Cited by 196 · see citing works
Pereira, R., Ribeiro, R., & Gonçalves, F. J. M. (2004) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2004.01.017 · Cited by 189 · see citing works
Collection of biological samples in forensic toxicology
Dinis‐Oliveira, R. J., Carvalho, F. D., Duarte, J. A., Remião, F., Marques, A., Santos, A., & Magalhães, T. (2010) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2010.497976 · Cited by 189 · see citing works
Hair analysis as a biomonitor for toxicology, disease and health status
Kempson, I. M., & Lombi, E. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15021a · Cited by 186 · see citing works
Value of hair analysis in postmortem toxicology
Kintz, P. (2004) · Forensic Science International · doi:10.1016/j.forsciint.2004.02.027 · Cited by 185 · see citing works
Dettenborn, L., Muhtz, C., Skoluda, N., Stalder, T., Steudte, S., Hinkelmann, K., Kirschbaum, C., & Otte, C. (2012) · Stress · doi:10.3109/10253890.2011.619239 · Cited by 181 · see citing works
Cortisol in hair, body mass index and stress-related measures
Tobias Stalder, A., Steudte‐Schmiedgen, S., Alexander, N., Miller, R. E., Gao, W., Dettenborn, L., & Kirschbaum, C. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.03.010 · Cited by 182 · see citing works
Assessing cortisol from hair samples in a large observational cohort: the Whitehall II study
Abell, J. G., Stalder, T., Ferrie, J. E., Shipley, M. J., Kirschbaum, C., Kivimäki, M., & Kumari, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.07.214 · Cited by 175 · see citing works
The association between adversity and hair cortisol levels in humans: A meta-analysis
Khoury, J. E., Bosquet Enlow, M., Plamondon, A., & Lyons-Ruth, K. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.01.009 · Cited by 170 · see citing works
Alves, A. C. H., Kucharska, A., Erratico, C., Xu, F., Hond, E. D., Koppen, G., Vanermen, G., Covaci, A., & Voorspoels, S. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-7748-1 · Cited by 174 · see citing works
Measures of maternal stress and mood in relation to preterm birth
Hoffman, M. C., Mazzoni, S. E., Wagner, B. D., Laudenslager, M. L., & Ross, R. G. (2016) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000001287 · Cited by 168 · see citing works
Determinants of hair cortisol and hair cortisone concentrations in adults.
Staufenbiel, S. M., Penninx, B., de Rijke, Y. D., van den Akker, E. V. D., & van Rossum, E. V. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.011 · Cited by 169 · see citing works
Elevated hair cortisol concentrations in endurance athletes
Skoluda, N., Dettenborn, L., Tobias Stalder, A., & Kirschbaum, C. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.001 · Cited by 169 · see citing works
Toward Standardization of Hair Cortisol Measurement
Russell, E., Kirschbaum, C., Laudenslager, M. L., Tobias Stalder, A., de Rijke, Y. B., van Rossum, E. F. C., Uum, S. H. M. V., & Koren, G. (2014) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000148 · Cited by 158 · see citing works
McKetin, R., Najman, J. M., Baker, A. L., Lubman, D. I., Dawe, S., Ali, R., Lee, N. K., Mattick, R. P., & Mamun, A. (2012) · Addiction · doi:10.1111/j.1360-0443.2012.03933.x · Cited by 147 · see citing works
Postmortem Drug Analysis: Analytical and Toxicological Aspects
Drummer, O. H., & Gerostamoulos, J. (2002) · Therapeutic Drug Monitoring · doi:10.1097/00007691-200204000-00002 · Cited by 145 · see citing works
Non-invasive monitoring of physiological markers in primates
Behringer, V., & Deschner, T. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.02.001 · Cited by 137 · see citing works
Mayer, S. E., Lopez-Duran, N. L., Sen, S., & Abelson, J. L. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.03.020 · Cited by 135 · see citing works
Hair analysis: exploring the state of the science.
Harkins, D. K., & Susten, A. S. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5842 · Cited by 131 · see citing works
Predictors of hair cortisol concentrations in older adults
Feller, S., Vigl, M., Bergmann, M. M., Boeing, H., Kirschbaum, C., & Tobias Stalder, A. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.007 · Cited by 127 · see citing works
Tobias Stalder, A., Kirschbaum, C., Heinze, K., Steudte‐Schmiedgen, S., Foley, P., Tietze, A., & Dettenborn, L. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.08.005 · Cited by 126 · see citing works
Anabolic steroids in sport: biochemical, clinical and analytical perspectives
Kicman, A. T., & Gower, D. B. (2003) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/000456303766476977 · Cited by 124 · see citing works
The Effect of Hair Color on the Incorporation of Codeine into Human Hair
Rollins, D. E., Wilkins, D. G., Krueger, G. G., Augsburger, M. P., Mizuno, A., O'Neal, C. L., Borges, C. R., & Slawson, M. H. (2003) · Journal of Analytical Toxicology · doi:10.1093/jat/27.8.545 · Cited by 120 · see citing works
Marroun, H. E., Tiemeier, H. W., Jaddoe, V. W. V., Albert Hofman, D., Mackenbach, J. P., Steegers, E. A. P., Verhulst, F. C., van den Brink, W., & Huizink, A. C. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.05.010 · Cited by 114 · see citing works
Maternal Lifetime Trauma Exposure, Prenatal Cortisol, and Infant Negative Affectivity
Enlow, M. B., Devick, K. L., Brunst, K. J., Lipton, L. R., Coull, B. A., & Wright, R. J. (2017) · Infancy · doi:10.1111/infa.12176 · Cited by 114 · see citing works
Assessing individual systemic stress through cortisol analysis of archaeological hair
Webb, E. C., Thomson, S., Nelson, A. J., White, C. D., Koren, G., Rieder, M. J., & Uum, S. H. M. V. (2009) · Journal of Archaeological Science · doi:10.1016/j.jas.2009.11.010 · Cited by 114 · see citing works
Flanagan, R. J., Connally, G., & Evans, J. (2005) · Toxicological Reviews · doi:10.2165/00139709-200524010-00005 · Cited by 111 · see citing works
Gentili, S., Cornetta, M., & Macchia, T. (2004) · Journal of Chromatography B · doi:10.1016/j.jchromb.2003.11.034 · Cited by 107 · see citing works
Baloch, S., Kazi, T. G., Baig, J. A., Afridi, H. I., & Arain, M. B. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137549 · Cited by 106 · see citing works
Braig, S., Grabher, F., Ntomchukwu, C., Reister, F., Stalder, T., Kirschbaum, C., Genuneit, J., & Rothenbacher, D. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.12.006 · Cited by 105 · see citing works
Hair-biomonitoring of organic pollutants
Schramm, K. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.04.017 · Cited by 105 · see citing works
Hair as an Alternative Matrix in Bioanalysis
Barbosa, J., Faria, J., Carvalho, F. D., Pedro, M., Queirós, O., Moreira, R. F., & Dinis‐Oliveira, R. J. (2013) · Bioanalysis · doi:10.4155/bio.13.50 · Cited by 102 · see citing works
Aas, M., Pizzagalli, D. A., Laskemoen, J. F., Reponen, E. J., Ueland, T., Melle, I., Agartz, I., Steen, N. E., & Andreassen, O. A. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.01.011 · Cited by 102 · see citing works
Testing for Drugs of Abuse in Children and Adolescents
Levy, S., Siqueira, L. M., COMMITTEE ON SUBSTANCE ABUSE, Levy, S., Ammerman, S. D., Gonzalez, P. K., Ryan, S. A., Siqueira, L. M., & Smith, V. C. (2014) · Pediatrics · doi:10.1542/peds.2014-0865 · Cited by 101 · see citing works
Diebig, M., Bormann, K. C., & Rowold, J. (2016) · The Leadership Quarterly · doi:10.1016/j.leaqua.2016.04.001 · Cited by 101 · see citing works
Newborn infants’ hair cortisol levels reflect chronic maternal stress during pregnancy
Romero‐Gonzalez, B., Caparrós-González, R. A., González-Pérez, R., Delgado-Puertas, P., & Peralta‐Ramírez, M. I. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200279 · Cited by 97 · see citing works
Yazdi, A. S., & Es’haghi, Z. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.07.110 · Cited by 96 · see citing works
Steudte‐Schmiedgen, S., Wichmann, S., Tobias Stalder, A., Hilbert, K., Muehlhan, M., Lueken, U., & Beesdo‐Baum, K. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.024 · Cited by 93 · see citing works
Wells, S. L., Tremblay, P. F., Flynn, A. M., Russell, E., Kennedy, J., Rehm, J. T., Uum, S. H. M. V., Koren, G., & Graham, K. (2014) · Stress · doi:10.3109/10253890.2014.930432 · Cited by 93 · see citing works
Kalliokoski, O., Jellestad, F., & Murison, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-48517-2 · Cited by 87 · see citing works
Klumbies, E., Braeuer, D., Hoyer, J., & Kirschbaum, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105670 · Cited by 89 · see citing works
Measuring Stress in Young Children Using Hair Cortisol: The State of the Science
Bates, R., Salsberry, P., & Ford, J. (2017) · Biological Research For Nursing · doi:10.1177/1099800417711583 · Cited by 88 · see citing works
Xiang, P., Sun, Q., Shen, B., Chen, P., Liu, W., & Shen, M. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2010.04.046 · Cited by 88 · see citing works
Stress and the Multiple-Role Woman: Taking a Closer Look at the “Superwoman”
Sumra, M. K., & Schillaci, M. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120952 · Cited by 92 · see citing works
Beyond Glucocorticoids: Integrating Dehydroepiandrosterone (DHEA) into Animal Welfare Research
Whitham, J. C., Bryant, J. L., & Miller, L. J. (2020) · Animals · doi:10.3390/ani10081381 · Cited by 86 · see citing works
Marroun, H. E., Tiemeier, H. W., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., van den Brink, W., & Huizink, A. C. (2010) · European Addiction Research · doi:10.1159/000320550 · Cited by 86 · see citing works
Hair cortisol and self-reported stress in healthy, working adults
Gidlow, C. J., Randall, J., Gillman, J. C., Silk, S., & Jones, M. V. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.022 · Cited by 87 · see citing works
Schreier, H. M. C., Enlow, M. B., Ritz, T., Coull, B. A., Gennings, C., Wright, R. O., & Wright, R. J. (2015) · Stress · doi:10.3109/10253890.2015.1117447 · Cited by 85 · see citing works
Weckesser, L. J., Dietz, F., Schmidt, K., Grass, J., Kirschbaum, C., & Miller, R. (2019) · Scientific Reports · doi:10.1038/s41598-018-37526-2 · Cited by 83 · see citing works
Natural environments and chronic stress measured by hair cortisol
Gidlow, C. J., Randall, J., Gillman, J. C., Smith, G. R., & Jones, M. V. (2016) · Landscape and Urban Planning · doi:10.1016/j.landurbplan.2015.12.009 · Cited by 83 · see citing works
Diagnostic opportunities based on skin biomarkers
Paliwal, S., Hwang, B. H., Tsai, K. Y., & Mitragotri, S. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.10.009 · Cited by 82 · see citing works
The influence of ethanol containing cosmetics on ethyl glucuronide concentration in hair
Ferreira, L. M., Binz, T. M., & Yegles, M. (2011) · Forensic Science International · doi:10.1016/j.forsciint.2011.10.015 · Cited by 81 · see citing works
Rothe, N., Steffen, J., Penz, M. S., Kirschbaum, C., & Walther, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.024 · Cited by 83 · see citing works
Hair cortisol as a biological marker for burnout symptomatology
Penz, M. S., Tobias Stalder, A., Miller, R. E., Ludwig, V. M., Kanthak, M. K., & Kirschbaum, C. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.07.485 · Cited by 81 · see citing works
Hair analysis for veterinary drug monitoring in livestock production
Gratacós-Cubarsí, M., Castellari, M., Valero, A., & Garcı́a-Regueiro, J. A. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.03.007 · Cited by 80 · see citing works
Methodological Considerations for Hair Cortisol Measurements in Children
Slominski, R. M., Rovnaghi, C. R., & Anand, K. J. S. (2015) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000209 · Cited by 80 · see citing works
Burnard, C. L., Ralph, C. R., Hynd, P., Edwards, J. H., & Tilbrook, A. J. (2016) · Animal Production Science · doi:10.1071/an15622 · Cited by 76 · see citing works
Coloring, Bleaching, and Perming
Kerekes, I., & Yegles, M. (2013) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e31828ca246 · Cited by 75 · see citing works
Ouellette, S. J., Russell, E., Kryski, K. R., Sheikh, H. I., Singh, S. M., Koren, G., & Hayden, E. P. (2015) · Developmental Psychobiology · doi:10.1002/dev.21302 · Cited by 74 · see citing works
Gentili, S., Torresi, A., Marsili, R., Chiarotti, M., & Macchia, T. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00522-6 · Cited by 74 · see citing works
Nature connectedness boosts the bright side of emotion regulation, which in turn reduces stress
Bakir-Demir, T., Berument, S. K., & Akkaya, S. (2021) · Journal of Environmental Psychology · doi:10.1016/j.jenvp.2021.101642 · Cited by 72 · see citing works
Namera, A., Urabe, S., Saito, T., Torikoshi, A., Shiraishi, H., Arima, Y., & Nagao, M. (2013) · Forensic Toxicology · doi:10.1007/s11419-013-0192-7 · Cited by 71 · see citing works
Chemical processing and shampooing impact cortisol measured in human hair
Hoffman, M. C., Karban, L. V., Benitez, P., Goodteacher, A., & Laudenslager, M. L. (2014) · Clinical and investigative medicine · doi:10.25011/cim.v37i4.21731 · Cited by 71 · see citing works
Wu, Y., Lin, K., Chen, S.-C., & Chang, Y. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.06.017 · Cited by 71 · see citing works
Laudenslager, M. L., Jorgensen, M. J., Grzywa, R. L., & Fairbanks, L. A. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.003 · Cited by 70 · see citing works
Wu, Y., Lin, K., Chen, S., & Chang, Y. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3409 · Cited by 70 · see citing works
Hair analysis by GC[sol ]MS[sol ]MS to verify abuse of drugs
Gambelunghe, C., Rossi, R., Ferranti, C., Rossi, R., & Bacci, M. (2005) · Journal of Applied Toxicology · doi:10.1002/jat.1054 · Cited by 70 · see citing works
Taylor, M., Lees, R., Henderson, G., Lingford‐Hughes, A., Macleod, J., Sullivan, J., & Hickman, M. (2017) · Drug and Alcohol Review · doi:10.1111/dar.12412 · Cited by 69 · see citing works
Fischer, S., Duncko, R., Hatch, S. L., Papadopoulos, A., Goodwin, L., Frissa, S., Hotopf, M., & Cleare, A. J. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.011 · Cited by 66 · see citing works
Kress, V., Steudte‐Schmiedgen, S., Kopp, M., Förster, A., Altus, C., Schier, C., Wimberger, P., Kirschbaum, C., von Soest, T., Weidner, K., et al. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01273 · Cited by 66 · see citing works
Olstad, D. L., Ball, K., Wright, C. R., Abbott, G., Brown, E. L., & Turner, A. I. (2016) · Stress · doi:10.3109/10253890.2016.1160282 · Cited by 66 · see citing works
Akinola, M., Kapadia, C., Lu, J. G., & Mason, M. F. (2018) · Academy of Management Perspectives · doi:10.5465/amp.2017.0094 · Cited by 68 · see citing works
- Authors
- Wennig, R.
- Affiliations
- University of Luxembourg (LU)
- Corresponding author
- Wennig, R.
- Venue
- Forensic Science International
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 107
- Issue
- 1-3
- Pages
- 5-12
- ISSN
- 0379-0738 (ISSN-L)
- OpenAlex
- W2080827705
- Cited by
- 677
- References
- 36
- Citations by year
- 2026: 30 · 2025: 38 · 2024: 47 · 2023: 55 · 2022: 45 · 2021: 52 · 2020: 38 · 2019: 37 · 2018: 39 · 2017: 35 · 2016: 36 · 2015: 27 · 2014: 30 · 2013: 20 · 2012: 26
- FWCI
- 11.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Forensic Science International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Keywords
- hair analysis, drug incorporation into hair, hair growth rate, hair color, cut-off values, time delay, interlaboratory comparability
- MeSH terms
- Forensic Medicine, Hair, Humans, Substance Abuse Detection
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