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Cited by 162Tea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesCoffee research and impacts

The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.

Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease

Widlansky, Michael E., Duffy, Stephen J., Hamburg, Naomi M., Gokce, Noyan, Warden, Beverly A., Wiseman, Sheila, Keaney, John F., Frei, Balz, Vita, Joseph A.·2005·Free Radical Biology and Medicine
DOI 10.1016/j.freeradbiomed.2004.11.013
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Abstract

We previously demonstrated that black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. To investigate potential mechanisms of this effect, we examined plasma catechins and systemic markers of oxidation, inflammation, and antioxidant protection from 66 subjects enrolled in that study. We collected samples at baseline, 2 h after 450 ml of black tea (acute), after 4 weeks of 900 ml of black tea per day (chronic), and after acute and chronic consumption of water. Total catechins increased 33% after acute tea (P < 0.05) and 29% after chronic tea (P < 0.05). Of individual catechins, plasma epicatechin gallate (ECG) concentration significantly increased with acute tea consumption, and plasma epicatechin (EC) increased with chronic tea consumption. Tea consumption did not improve plasma antioxidant capacity and did not reduce urinary 8-hydroxy-2'-deoxyguanosine, or urinary 8-isoprostane levels. Changes in catechin levels did not correlate with changes in endothelial function, plasma markers of oxidative stress, or C-reactive protein. In contrast, endothelial function at baseline correlated with dietary flavonoid intake (beta = 0.32, P = 0.02) and with baseline plasma EC concentration after adjusting for confounding variables (beta = 0.39, P = 0.03). These findings suggest that the benefits of black tea consumption on endothelial function may not be attributable to tea catechins or a systemic antioxidant or anti-inflammatory effect. Chronic dietary flavonoid status appears to relate to endothelial function, possibly suggesting that other flavonoids or polyphenolic components of tea favorably influence vascular health and risk for cardiovascular disease.

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Crossref · 10.1016/j.freeradbiomed.2004.11.013

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Metadata

Authors
Widlansky, M. E., Duffy, S. J., Hamburg, N. M., Gokce, N., Warden, B. A., Wiseman, S., Keaney, J. F., Frei, B., & Vita, J. A.
Affiliations
  • Boston University (US)
  • Unilever Research and Development Vlaardingen (NL)
  • Oregon State University (US)
Corresponding author
Vita, Joseph A.
ORCID
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2005-02
Volume
38
Issue
4
Pages
499-506
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/j.freeradbiomed.2004.11.013
OpenAlex
W2057732608
Cited by
162
References
48
Citations by year
2026: 4 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 3 · 2015: 8 · 2014: 11 · 2013: 19 · 2012: 8
FWCI
7.06
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (P01HL060886, HL 060886, T32HL007224, K23HL004425)
  • National Center for Research Resources (M01RR000533)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords
black tea consumption, tea catechins, epicatechin, epicatechin gallate, endothelial function, coronary artery disease, oxidative stress, inflammation, antioxidant capacity, urinary 8-hydroxy-2'-deoxyguanosine, C-reactive protein, dietary flavonoids, cardiovascular risk
MeSH terms
Catechin, Coronary Artery Disease, Female, Humans, Inflammation, Male, Phytotherapy, Middle Aged, Oxidation-Reduction, Plant Extracts, Tea, Oxidative Stress, Endothelial Cells

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