Concurrent Administration of Coenzyme Q10 and α-Tocopherol Improves Learning in Aged Mice
Abstract
The main purpose of this study was to determine whether supplemental intake of coenzyme Q10 (CoQ) (ubiquinone-10) or alpha-tocopherol, either alone or together, could improve brain function of aged mice, as reflected in their cognitive or psychomotor performance. Separate groups of aged mice (24 months) were administered either CoQ (123 mg/kg/day), or alpha-tocopherol acetate (200 mg/kg/day), or both, or the vehicle (soybean oil) via gavage for a period of 14 weeks. Three weeks following the initiation of these treatments, mice were given a battery of age-sensitive behavioral tests for the assessment of learning, recent memory, and psychomotor function. In a test that required the mice to rapidly identify and remember the correct arm of a T-maze, and to respond preemptively in order to avoid an electric shock, the intake of alpha-tocopherol plus CoQ resulted in more rapid learning compared to the control group. Learning was not significantly improved in the mice receiving CoQ or alpha-tocopherol alone. None of the treatments resulted in a significant improvement of psychomotor performance in the old mice. In a separate study, treatment with higher doses of CoQ alone (250 or 500 mg/kg/day) for 14 weeks failed to produce effects comparable to those of the combination of alpha-tocopherol and CoQ. The apparent interaction of CoQ and alpha-tocopherol treatments is consistent with the previous suggestion, based on biochemical studies, that coenzyme Q and alpha-tocopherol act in concert. Overall, the findings suggest that concurrent supplementation of alpha-tocopherol with CoQ is more likely to be effective as a potential treatment for age-related learning deficits than supplementation with CoQ or alpha-tocopherol alone.
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Although beneficial, lifelong supplementation with CoQ10 may also be deleterious.
“Although beneficial, lifelong supplementation with CoQ10 may also be deleterious [92,93,94].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [94]
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- Authors
- Mcdonald, S. R., S. Sohal, R., & Forster, M. J.
- Affiliations
- University of North Texas Health Science Center (US)
- Corresponding author
- Forster, Michael J.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 38
- Issue
- 6
- Pages
- 729-736
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1967751169
- Cited by
- 77
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG022550, R01AG017526)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- coenzyme Q10, alpha-tocopherol, vitamin E, combination supplementation, aging, learning, memory, cognitive function, psychomotor performance, T-maze, aged mice, antioxidants
- MeSH terms
- Aging, Animals, Antioxidants, Body Weight, Coenzymes, Dose-Response Relationship, Drug, Free Radicals, Learning, Male, Memory, Mice, Inbred C57BL, Psychomotor Performance, Soybean Oil, Time Factors, Ubiquinone, Maze Learning, alpha-Tocopherol, Mice
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