Prolonged Intake of Coenzyme Q10 Impairs Cognitive Functions in Mice
Open accessAbstract
Coenzyme Q(10) (CoQ(10)) is widely consumed as a dietary supplement to enhance bioenergetic capacity and to ameliorate the debilitative effects of the aging process or certain pathological conditions. Our main purpose in this study was to determine whether CoQ(10) intake does indeed attenuate the age-associated losses in motor, sensory, and cognitive functions or decrease the rate of mortality in mice. Mice were fed a control nonpurified diet or that diet containing 0.68 mg/g (low dosage) or 2.6 mg/g (high dosage) CoQ(10), starting at 4 mo of age, and were tested for sensory, motor, and cognitive function at 7, 15, and 25 mo of age. Amounts of the ubiquinols CoQ(9)H(2) and CoQ(10)H(2) measured in a parallel study were augmented in the cerebral cortex but not in any other region of the brain. Intake of the low-CoQ(10) diet did not affect age-associated decrements in muscle strength, balance, coordinated running, or learning/memory, whereas intake at the higher amount increased spontaneous activity, worsened the age-related losses in acuity to auditory and shock stimuli, and impaired the spatial learning/memory of old mice. The CoQ(10) diets did not affect survivorship of mice through 25 mo of age. Our results suggest that prolonged intake of CoQ(10) in low amounts has no discernable impact on cognitive and motor functions whereas intake at higher amounts exacerbates cognitive and sensory impairments encountered in old mice. These findings do not support the notion that CoQ(10) is a fitness-enhancing or an "antiaging" substance under normal physiological conditions.
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Although beneficial, lifelong supplementation with CoQ10 may also be deleterious.
“Although beneficial, lifelong supplementation with CoQ10 may also be deleterious [92,93,94].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [93]
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- Authors
- Sumien, N., Heinrich, K. R., Shetty, R. A., Sohal, R. S., & Forster, M. J.
- Affiliations
- University of North Texas Health Science Center (US)
- University of Southern California (US)
- Corresponding author
- Forster, Michael J.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 139
- Issue
- 10
- Pages
- 1926-1932
- ISSN
- 0022-3166 (ISSN-L)
- PMC
- PMC2744613
- OpenAlex
- W2158884281
- Cited by
- 46
- References
- 53
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 3 · 2016: 4 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01 AG17526, R01AG017526)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- coenzyme Q10, dietary supplementation, aging, cognitive function, spatial learning and memory, sensory impairment, motor function, ubiquinol, cerebral cortex, anti-aging, mortality, mice
- MeSH terms
- Aging, Animals, Body Weight, Brain, Brain Chemistry, Cognition, Drug Administration Schedule, Eating, Male, Mice, Inbred C57BL, Ubiquinone, Dietary Supplements, Mice
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